The Plk1 Piece of the Nuclear Envelope Disassembly Puzzle.
Dawson TR , Wente SR , . Developmental cell. 2017 10 23; 43(2). 115-117
- PMID: 29065301 [PubMed].
Reporting in this issue of Developmental Cell, Linder et al. (2017) and Martino et al. (2017) reveal in highly complementary studies that Plk1 is recruited to the nuclear pore complex upon mitotic entry, where it acts with Cdk1 to hyperphosphorylate nucleoporin interfaces to promote NPC disassembly and nuclear envelope breakdown.