Stephen Doster

As a member of the class of ABC (ATP-binding cassette) transporters, the P-glycoprotein (P-gp) harnesses energy from ATP hydrolysis to power conformational changes that transfer substrates across the cell membrane against a concentration gradient. P-gp transports more than 200 structurally diverse substrates, thereby playing a role in the pharmacokinetics of… Read More

May. 9, 2019, 10:30 AM by Sanjay Mishra Basement membranes are an ancient form of extracellular matrix composed of complex biological molecules including Collagen IV. As important structural and functional components of tissues, basement membranes are subject to environmental damage, but little is known about how they are repaired. Now, a… Read More

May. 9, 2019, 9:03 AM From left, Brinda Selvaraj, Jonathan Sheehan, PhD, Hassane Mchaourab, PhD, and colleagues are part of the new trans-institutional Program in the Molecular Basis of Genetic Diseases. (photo by Steve Green) by Bill Snyder Vanderbilt has established a program to help researchers determine more precisely how… Read More

May. 8, 2019, 8:53 AM Vanderbilt University sophomore Aakash Basu and junior Eric Zhang have been named Goldwater Scholars. The Goldwater Scholarship is the premier award for undergraduate STEM students who show exceptional promise of becoming the nation’s next generation of research leaders. Basu and Zhang were selected from a… Read More

by Kate Derrick May. 3, 2019, 8:15 AM (L to r) Brian T. McCann, Matthew S. Freiberg, Provost Susan R. Wente, Edward Wright-Rios, Ben Ho Park, Owen D. Jones, Carl H. Johnson (Joe Howell/Vanderbilt University) Vanderbilt’s six newest endowed chairs were honored by colleagues,… Read More

May. 2, 2019, 8:33 AM by Kelsey Herbers The American Society of Gene and Cell Therapy (ASGCT) has appointed Matthew Wilson, MD, PhD, associate professor of Medicine in Vanderbilt’s Division of Nephrology and Hypertension, to its board of directors. Beginning in May 2019, Wilson will serve a three-year term as… Read More

Apr. 25, 2019, 11:30 AM by Leigh MacMillan The novel antibacterial drug gepotidacin is showing clinical promise for the treatment of skin infections and gonorrhea. Gepotidacin was developed in response to the rising bacterial resistance to fluoroquinolone drugs such as ciprofloxacin. Like fluoroquinolones, gepotidacin acts on the bacterial enzymes gyrase… Read More

Apr. 25, 2019, 11:00 AM by Bill Snyder Arguably the most replicated post-mortem finding in schizophrenia is the loss of dendritic spines from pyramidal cells in the brain’s prefrontal cortex, which is involved in decision-making, attention and moderating social behavior. Pyramidal cells are cortical neurons that communicate with distant neurons. Read More

The Scream, Edvard Munch, PD-US-expired. Disorders arising from trauma and stress, such as post-traumatic stress disorder (PTSD), are a major cause of morbidity and mortality, and they exact a huge economic toll on our society. Hence, a major effort is underway to find new treatments for these diseases. A clue… Read More

Apr. 25, 2019, 8:46 AM Investigators using MRI technology to study changes in pancreatic volume to better understand the progression of Type 1 diabetes include, from left, Melissa Hilmes, MD, Daniel Moore, MD, PhD, Alvin Powers, MD, Jon Williams, PhD, and Jack Virostko, PhD. (photo by Jessica Kimber) by Jill… Read More