Research, News & Discoveries

By Suneethi Sivakumaran C-MYC, a variant of MYC, and MAX bound to DNA. (Molekuul.be, stock.adobe.com) Cancers are complex and diverse in nature, assailing the human body through different mechanisms. Cancer cells outsmart normal cells through myriad mechanisms, including sustained proliferation, insensitivity to growth suppressors, and resistance to cell… Read More

Carlos Lopez (Biochemistry) has received a National Science Foundation Faculty Early Career Development (CAREER) award, the most prestigious NSF award that supports early-career faculty. Lopez’s research attempts to parse out the role of noise and randomness in determining cell fate. Read More

Jan. 29, 2020, 2:23 PM by Bill Snyder MYC is a family of three related proteins that are overexpressed in cancer and which contribute to an estimated 100,000 cancer deaths annually in the United States. Efforts to block MYC directly have failed. Fortunately, these proteins have an Achilles’ heel —… Read More

Jan. 29, 2020, 3:14 PM by Kelsey Herbers Stimulating neural activity between the amygdala and the nucleus accumbens — a brain region associated with pleasure — impairs social function even though mice find the stimulation rewarding, a new study published by Vanderbilt researchers in The Journal of Clinical Investigation… Read More

Jan. 27, 2020, 9:00 AM by Leigh MacMillan Free radicals produced during oxidative stress react with membrane fatty acids to yield highly reactive lipid aldehydes, which can modify proteins and cause cellular or tissue damage. The aldehyde HNE has been shown to modify high-density lipoprotein (HDL, the so-called good cholesterol)… Read More

Jan. 23, 2020, 9:17 AM by Bill Snyder Using part of an antibody isolated at Vanderbilt University Medical Center that “broadly neutralizes” the human dengue virus, biologists at the University of California San Diego and colleagues have disarmed the mosquito that transmits the disabling and potentially deadly tropical infection. Reporting in… Read More

By Sohini Roy New research can lead to improved vaccines against the flu, including strains such as H7N9 and antiviral-resistant strains. Image by Heather Hazzan, SELF Magazine. Published under a CC BY 2.0 license. Obtained from Flickr. Asian lineage avian influenza virus (H7N9) is… Read More

Jan. 16, 2020, 11:03 AM by Bill Snyder Researchers at Vanderbilt University Medical Center have created the world’s first laboratory model of precancerous changes in the lining of the stomach, a scientific tour de force that is helping to unlock the mysteries of gastric cancer development. Their achievement, described recently… Read More

Jan. 13, 2020, 11:00 AM Cartilage cells in the zebrafish model of the disease CATIFA (right) have reduced volumes and irregular shapes compared to healthy cartilage cells (left) because of a defect in collagen secretion. (image courtesy of Ela Knapik, MD) by Leigh MacMillan Studies that started in zebrafish have… Read More

Jan. 13, 2020, 8:30 AM by Leigh MacMillan The journal cover featured an artistic representation of Acinetobacter baumannii infecting the lung, which was created by undergraduate student Ayomide Sanusia. Acinetobacter baumannii — a cause of pneumonia, sepsis, wound and burn infections — is becoming more prevalent and resistant… Read More