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School of Medicine Basic Sciences

Department of Biochemistry

Biochemistry is part of Basic Sciences in the Vanderbilt University School of Medicine. Basic Sciences is comprised of the departments biochemistry, cell and developmental biology, pharmacology, and molecular physiology and biophysics. Learn more about our thriving research community by clicking the buttons below.

 

 

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What is Biochemistry?

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The Department of Biochemistry is dedicated to discovering the fundamental mechanisms of biological processes, bridging these discoveries with clinical applications to improve human health, and training the next generation of biomedical scientists. Our investigators are leaders in applying advanced approaches in structural biology, mass spectrometry, chemical biology, cell biology, and genetics to thematic areas like DNA and RNA metabolism, cell division, enzymology, molecular cancer biology, signaling, toxicology, and metabolism. We are united in seeking molecular answers to biomedical questions. 

The Department has 26 primary investigator-track faculty and another ~50 secondary, educator, and research-track faculty. An exceptional group of graduate, medical, and undergraduate students and large cohort of post-doctoral fellows train in our laboratories supported by over $30M in funding. 

As one of four basic science departments in the School of Medicine Basic Sciences, Biochemistry benefits from being affiliated with a large medical center and medical school as well as Colleges of Arts and Sciences, Engineering, and Connected Computing. Our unique structure allows us to strategically invest in infrastructure, initiatives, and people to fulfill our missions of research, education, and service. 

Biochemistry investigators have received major awards including election to the National Academy of Sciences, and a Nobel Prize in Physiology or Medicine (Stanley Cohen, 1986). Our culture of excellence, collaboration, innovation, rigor, dedication, inclusiveness, ambition, kindness, and resiliency facilitates high impact research, education, and service. – David Cortez, Chair 

We invite queries regarding graduate studies, postdoctoral training, and faculty positions.

A recent article about the Biochemistry Department can be found here.

Biochemistry Announcements

Biochemistry News

SOMBS researchers land Susan G. Komen research grants

July 2026-Jennifer Pietenpol (Biochemistry) and Ben Ho Park (Program in Cancer Biology) were announced as recipients of Susan G. Komen grants. Komen is the largest nonprofit funder of breast cancer research outside of the U.S. government, having invested more than $1.1 billion in research since its founding.

Read more about SOMBS researchers and Susan G. Komen research grants.

Marked for destruction: designing new targets for protein degradation therapies

June 25, 2026-Targeted protein degradation (TPD) represents an emerging class of therapeutics that selectively degrades disease-relevant proteins.

For example, targeted degradation of oncoproteins in a tumor can inhibit tumor growth while minimizing the toxic side effects of traditional chemotherapy. The degradation relies on the endogenous mammalian ubiquitin ligase pathway, specifically through the use of proteolysis targeting chimera (PROTAC) molecules which recruit E3 ligases to target proteins for ubiquitination. However, TPD strategies are hindered by the limited number of E3 ligases with useful targets.

Read more about designing new targets for protein degradation therapies.

School of Medicine Spring Faculty Assembly honors 14 ‘outstanding’ teachers, clinicians and researchers

June 17, 2026-Fourteen faculty members of Vanderbilt University School of Medicine were recognized for Excellence in Teaching, Extraordinary Performance of Clinical Service, and Outstanding Contributions to Research during the annual Spring Faculty Assembly on May 29.

In introductory remarks, Jeff Balser, MD, PhD, President and CEO of Vanderbilt Health and Dean of the School of Medicine, noted that Vanderbilt’s ranking as one of the nation’s top academic medical centers reflects its commitment to invest in medical research and train the next generation of health care leaders.

Read more about the 2026 spring faculty assembly award winners.
10 years SOMBS

Looking to become a biochemistry undergraduate major?

Contact the Biochemistry and Chemical Biology Undergraduate Major Program at https://as.vanderbilt.edu/biochemistry-chemical-biology/