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Houra Merrikh, Ph.D.

Professor, Biochemistry, PMI, VI4

DNA Replication, mutagenesis, & evolution

Name: Houra Merrikh
Title: Professor of Biochemistry
Department: Biochemistry
Office Address: 639E Light Hall
Phone Number: 615-343-3846
Lab URL:

Research Description: Our lab uses a variety of cutting edge tools to study collisions between DNA replication forks and RNA polymerases. These include in vivo single molecule microscopy, deep sequencing, bioinformatics, and lab-based experimental evolution. We pair these new technologies with classical genetics and molecular biology techniques, typically using the model bacterium Bacillus subtilis. This naturally competent bacteria grows quickly and is genetically tractable making experiments fast and efficient. In recent years we have also begun studying DNA replication in pathogenic bacteria including Mycobacterium tuberculosisPseudomonas aeruginosa, and Salmonella enterica.