News
Exosome secretion is enhanced by invadopodia and drives invasive behavior
Dec. 12, 2013—Exosome secretion is enhanced by invadopodia and drives invasive behavior Daisuke Hoshino1, Kellye C. Kirkbride1, Kaitlin Costello1, Emily S. Clark2, Seema Sinha1, Nathan Grega-Larson3, Matthew J. Tyska3 and Alissa M. Weaver1, 4 1 Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA 2 Department of Microbiology and Immunology, University of Miami Medical...
AAAS David Miller
Dec. 3, 2013—AAAS Council Elects 388 New AAAS Fellows "Meeting Global Challenges: Discovery and Innovation" is the theme for the 2014 AAAS Annual Meeting but it also describes the achievements of the new AAAS Fellows. For example, Robert Geahlen, distinguished professor of medicinal chemistry at Purdue University, discovered Syk, an enzyme that affects the growth of different...
Gould BEST Award
Dec. 3, 2013—NIH announces awards to strengthen the biomedical research workforce BEST awards encourage innovative approaches to address workforce challenges Print this pageShare on email Share on facebook Share on twitter The National Institutes of Health is making available approximately $3.7 million for awards to enhance training opportunities for graduate students and postdoctoral scholars to prepare them...
Post-doc Publication: biallelic disruption in zebrafish
Nov. 15, 2013— Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Jao LE, Wente SR, Chen W. Source Department of Cell and Developmental Biology and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-8240. Abstract A simple and robust method for targeted mutagenesis in zebrafish has...
Student Publication: Nuclear Asunder regulates cytoplasmic dynein
Nov. 15, 2013—Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the Integrator complex Jeanne N. Jodoina, Poojitha Sitarama, Todd R. Albrechtb, Sarah B. Mayb, Mohammad Shboulc, Ethan Leea, Bruno Reversadec,d, Eric J. Wagnerb,1, and Laura A. Leea,1 Abstract We previously reported that Asunder (ASUN) is essential for recruitment of dynein motors to the nuclear envelope...
2013 Chancellor’s Award for Research
Nov. 15, 2013—This award recognizes faculty members for excellence in research, scholarship or creative expression. Dr. Casagrande won this award for a ground-breaking paper in Nature Neuroscience, in which a novel linkage was identified between primary visual cortex of the brain and the thalamus, which controls the ability of the visual system to focus. Remarkably, when a...
The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors
Nov. 11, 2013—The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors Jonathan T. Fleming, Wenjuan He, Chuanming Hao, Tatiana Ketova, Fong C. Pan, Christopher C.V. Wright, Ying Litingtung, Chin Chiang Highlights •Purkinje neurons signal bidirectionally to expand functionally divergent cell types •Nascent white matter harbors molecularly distinct but lineally related astroglia...
The Purkinje neuron is a central regulator of cerebellar neurogenesis
Nov. 11, 2013—The Purkinje Neuron Acts as a Central Regulator of Spatially and Functionally Distinct Cerebellar Precursors Jonathan T. Fleming, Wenjuan He, Chuanming Hao, Tatiana Ketova, Fong C. Pan, Christopher C.V. Wright, Ying Litingtung, Chin Chiangemail DOI: http://dx.doi.org/10.1016/j.devcel.2013.10.008 Highlights •Purkinje neurons signal bidirectionally to expand functionally divergent cell types •Nascent white matter harbors molecularly...
Wnt signaling drives synovial sarcoma development: implications for treatment
Nov. 3, 2013—Targeting the Wnt Pathway in Synovial Sarcoma Models Whitney Barham1, Andrea L. Frump5, Taylor P. Sherrill3, Christina B. Garcia7, Kenyi Saito-Diaz5, Michael N. VanSaun2, Barbara Fingleton1, Linda Gleaves3, Darren Orton6, Mario R. Capecchi8, Timothy S. Blackwell3, Ethan Lee4,5, Fiona Yull1 and Josiane E. Eid1 Abstract Synovial sarcoma is an aggressive soft-tissue malignancy of children and...
LCCS1 pathology linked to defects in Gle1 oligomerization and mRNA export disregulation
Oct. 24, 2013—Summary The conserved multifunctional protein Gle1 regulates gene expression at multiple steps: nuclear mRNA export, translation initiation, and translation termination. A GLE1 mutation (FinMajor) is causally linked to human lethal congenital contracture syndrome-1 (LCCS1); however, the resulting perturbations on Gle1 molecular function were unknown. FinMajor results in a proline-phenylalanine-glutamine peptide insertion within the uncharacterized Gle1...
Retinotopic maps in the pulvinar of bush baby
Oct. 15, 2013—Retinotopic maps in the pulvinar of bush baby (otolemur garnettii) K. Li1, J. Patel2, G. Purushothaman2, R.T. Marion3 andV.A. Casagrande1,2,3,4,* Article first published online: 23 AUG 2013 DOI: 10.1002/cne.23358 Abstract Despite its anatomical prominence, the function of the primate pulvinar is poorly understood. A few electrophysiological studies in simian primates have investigated the functional organization...
CK1 is required for a mitotic checkpoint that delays cytokinesis
Oct. 7, 2013—CK1 is required for a mitotic checkpoint that delays cytokinesis Alyssa E. Johnson, Jun-Song Chen, Kathleen L. Gould Highlights •Dma1’s FHA domain binds to a pTXXpS phosphomotif on Sid4 •CK1 is required for Dma1-dependent Sid4 ubiquitination •CK1 phosphorylation of Sid4 is required for the Dma1-dependent mitotic checkpoint •CK1 concentrates at SPBs and phosphoprimes Sid4 for...
An oligomeric switch that modulates cytokinetic formin function
Oct. 1, 2013—SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis K. Adam Bohnert1, Agnieszka P. Grzegorzewska2,3,6, Alaina H. Willet1, Craig W. Vander Kooi4,5, David R. Kovar2,3 and Kathleen L. Gould1,7 Abstract Many eukaryotes accomplish cell division by building and constricting a medial actomyosin-based cytokinetic ring (CR). In Schizosaccharomyces pombe, a Hippo-related signaling pathway termed the septation...
Generalized ideal observer model for decoding sensory neural responses
Sep. 19, 2013—A Generalized ideal observer model for decoding sensory neural responses Gopathy Purushothaman and Vivien A. Casagrande Front. Psychol., 19 September 2013 | doi: 10.3389/fpsyg.2013.00617 Abstract We show that many ideal observer models used to decode neural activity can be generalized to a conceptually and analytically simple form. This enables us to study the statistical properties...