News
Developmental Biology Vol363-issue2
Mar. 19, 2012—Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors Abstract The enteric nervous system (ENS) arises from the coordinated migration, expansion and differentiation of vagal and sacral neural crest progenitor cells. During development, vagal neural crest cells enter the foregut and migrate in a rostro-to-caudal direction, colonizing the...
Tyska Lab demonstrate enterocyte microvilli-derived vesicles a novel form of defense
Mar. 12, 2012—Info: Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions David A. Shifrin, Jr., Russell E. McConnell, Rajalakshmi Nambiar, James N. Higginbotham, Robert J. Coffey, and Matthew J. Tyska Current Biology; April 10, 2012 Abstract: The continuous monolayer of intestinal epithelial cells (IECs) lining the gut lumen functions as the site of nutrient absorption...
Kaverina Lab centrosomal versus Golgi-derived microtubules
Mar. 12, 2012—Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not for maintenance Abstract Assembly of an integral Golgi complex is driven by microtubule (MT)-dependent transport. Conversely, the Golgi itself functions as an unconventional MT-organizing center (MTOC). This raises the question of whether Golgi assembly requires centrosomal MTs or can...
A zebrafish model of lethal congenital contracture syndrome
Mar. 12, 2012—In humans, GLE1 is mutated in lethal congenital contracture syndrome 1 (LCCS1) leading to prenatal death of all affected fetuses. Although the molecular roles of Gle1 in nuclear mRNA export and translation have been documented, no animal models for this disease have been reported. To elucidate the function of Gle1 in vertebrate development, we used...
Myosin-1a membrane binding in microvilli
Feb. 29, 2012—One of the most abundant components of the enterocyte brush border is the actin-based monomeric motor, myosin-1a (Myo1a). Within brush border microvilli, Myo1a carries out a number of critical functions at the interface between membrane and actin cytoskeleton. Proper physiological function of Myo1a depends on its ability to bind to microvillar membrane, an interaction mediated...
Kathy Gould elected as an AAAS Fellow
Feb. 8, 2012—"In November 2011, the AAAS Council elected 539 members as Fellows of AAAS. These individuals will be recognized for their contributions to science and technology at the Fellows Forum to be held on 18 February 2012 during the AAAS Annual Meeting in Vancouver, Canada. The new Fellows will receive a certificate and a blue and...
A new Cdk1 substrate Nsk1 regulates kinetochore
Dec. 8, 2011—Jun-Song Chen1,2, Lucy X. Lu1,2, Melanie D. Ohi2, Kevin M. Creamer3,4, Chauca English2, Janet F. Partridge4, Ryoma Ohi2, and Kathleen L. Gould1,2 1 Howard Hughes Medical Institute & 2 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37212 3 Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center,...
GABAergic synapses in C. elegans
Dec. 7, 2011—Author contributions: S.C.P., J.D.W., J.E.R., and D.M.M. designed research; S.C.P., J.D.W., and J.E.R. performed research; M.S. and W.W.W. contributed unpublished reagents/analytic tools; S.C.P., J.D.W., J.E.R., and D.M.M. analyzed data; S.C.P. and D.M.M. wrote the paper. Abstract Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely...
Diabetes Day
Nov. 28, 2011—Jennifer Plank, a current student in Cell and Developmental Biology, received the award in the graduate student category. Working with Patricia Labosky, Ph.D., Jennifer studies regulators of pancreatic beta cell mass expansion. She has identified important roles for the neural crest and for the transcription factor Foxd3 in the beta cell. The findings from both...
Susan Wente named by the ASCB’s Women in Cell Biology (WICB)
Oct. 19, 2011—Susan Wente, Associate Vice Chancellor for Research, Senior Associate Dean for Biomedical Sciences, and Professor, Cell and Developmental Biology, Vanderbilt University School of Medicine, was named by the ASCB’s Women in Cell Biology (WICB) Committee to receive the 2011 WICB Senior Award. Wente is a world-recognized leader and has made seminal advances in three key...
Loss of Foxd3 results in decreased beta cell proliferation and glucose intolerance during pregnancy
Oct. 19, 2011—Jennifer L. Plank, Audrey Y. Frist, Alison W. LeGrone, Mark A. Magnuson and Patricia A. Labosky – Author Affiliations Department of Cell and Developmental Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Center for Stem Cell Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Program in Developmental Biology (J.L.P., A.Y.F., A.W.L., M.A.M., P.A.L.), Department of Molecular Physiology and Biophysics...
Genetic interactions between hepatocyte nuclear factor-6 and notch signaling
Sep. 20, 2011—Genetic interactions between hepatocyte nuclear factor-6 and notch signaling regulate mouse intrahepatic bile duct development in vivo Charles Vanderpool1, Erin E. Sparks2, Kari A. Huppert2, Maureen Gannon3, Anna L. Means4, Stacey S. Huppert2,*,† DOI: 10.1002/hep.24631 Abstract Notch signaling and hepatocyte nuclear factor-6 (HNF-6) are two genetic factors known to affect lineage commitment in the bipotential...
Mechanism of plus-end targeting by the kinesin-8 Kif18A
Sep. 1, 2011—A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A Jason Stumpff2, 4, Yaqing Du1, 4, Chauca A. English1, Zoltan Maliga3, Michael Wagenbach2, Charles L. Asbury2, Linda Wordeman2, 4, , and Ryoma Ohi1, 4, 1 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, 37232 2 Department of Physiology and...
cell reprogramming by forced Pdx1 expression
Sep. 1, 2011—Context-specific α-to-β-cell reprogramming by forced Pdx1 expression Yu-Ping Yang1,Fabrizio Thorel2,Daniel F. Boyer1,Pedro L. Herrera2 and Christopher V.E. Wright1,3 1Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA; 2Department of Cell Physiology and Metabolism, University of Geneva Faculty of Medicine, CH-1211 Geneva 4, Switzerland Abstract...
Neural crest stem cell multipotency requires Foxd3
Apr. 19, 2011—eural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates Nathan A. Mundell1,2,3 and Patricia A. Labosky1,2,3,4,* 1 Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232-0494, USA. 2 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0494, USA. 3 Program in Developmental Biology,...