News
Student Publication: Asunder promotes dynein recruitment
Apr. 3, 2013—Jodoin JN, Shboul M, Sitaram P, Zein-Sabatto H, Reversade B, Lee E, Lee LA. Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232-8240, USA. Abstract Recruitment of dynein motors to the nuclear surface is an essential step for nucleus-centrosome coupling in prophase. In cultured human cells, this dynein pool is anchored...
Faculty Appointment: Ken Lau, Ph.D.
Mar. 21, 2013—Cell & Developmental Biology welcomes new faculty member Ken Lau, Ph.D. Dr. Ken Lau comes to Vanderbilt after completing his post postdoctorate training in the laboratory of Kenvi Hargis, Ph.D. In the Molecular Pathology Unit at the Massachusetts General Hospital and Harvard Medical School. Dr. Lau was chosen to join the Department of Cell and...
CDB Announces Mary Heath as new Department Administrator
Mar. 21, 2013—Ian G. Macara, Ph.D. Louise B. McGavock and Chair, Department of Cell and Developmental Biology Vanderbilt University Medical School Mary Heath, MBA, CFA, CRA, will assume the position of Departmental Administrator in the Department of Cell and Developmental Biology on April 22, 2013. Ms. Heath will be making the transition from Boston to Nashville as...
Morphological and neurochemical comparisons between pulvinar and V1 projections to V2
Jan. 22, 2013—Morphological and neurochemical comparisons between pulvinar and V1 projections to V2 Roan Marion1, Keji Li2, Gopathy Purushothaman3, Yaoguang Jiang2 andVivien A. Casagrande1 Article first published online: 22 JAN 2013 DOI: 10.1002/cne.23203 Abstract The flow of visual information is clear at the earliest stages: the retina provides the driving (main signature) activity for the lateral geniculate...
Loss of the par3 polarity protein promotes breast tumorigenesis and metastasis.
Nov. 23, 2012—McCaffrey LM, Montalbano J, Mihai C, Macara IG. Rosalind and Morris Goodman Cancer Research Centre, Department of Oncology, McGill University, Montreal H3A 1A3, Canada. Electronic address: luke.mccaffrey@mcgill.ca. Abstract Loss of epithelial organization is a hallmark of carcinomas, but whether polarity regulates tumor growth and metastasis is poorly understood. To address this issue, we depleted the...
Cytokinetic regulation of cell polarity
Nov. 23, 2012—The rod-shaped fission yeast Schizosaccharomyces pombe, which undergoes cycles of monopolar-to-bipolar tip growth, is an attractive organism for studying cell-cycle regulation of polarity establishment. While previous research has described factors mediating this process from interphase cell tips, we found that division site signaling also impacts the re-establishment of bipolar cell growth in the ensuing cell...
Spatial regulation of a cell cycle phosphatase
Nov. 23, 2012—The rod-shaped fission yeast Schizosaccharomyces pombe, which undergoes cycles of monopolar-to-bipolar tip growth, is an attractive organism for studying cell-cycle regulation of polarity establishment. While previous research has described factors mediating this process from interphase cell tips, we found that division site signaling also impacts the re-establishment of bipolar cell growth in the ensuing cell...
Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches Posted August 13th, 2012 by admin
Aug. 13, 2012—Lucy X. Lua, Maria Rosa Domingo-Sananesb, Malwina Huzarskaa, Bela Novakb, and Kathleen L. Gould a,c,1 + Author Affiliations a Department of Cell and Developmental Biology, and c The Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, TN 37212; and b Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford...
Lis-1 and asunder regulate dynein
Aug. 13, 2012—oojitha Sitaram, Michael A. Anderson*, Jeanne N. Jodoin, Ethan Lee and Laura A. Lee‡ + Author Affiliations Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, U-4225 Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA. + Author Notes * Present address: Georgetown University Law Center, 600 New Jersey Avenue...
asymmetry for cytokinesis
May. 14, 2012—The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11 Anna Feoktistovaa, Jennifer Morrell-Falveya, Jun-Song Chena, N. Sadananda Singh, Mohan K. Balasubramanianb,c, and Kathleen L. Goulda,1 + Affiliations aHoward Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37212 bTemasek...
Identification of XIAP as a critical regulator of Wnt signaling
Mar. 21, 2012—beta-catenin accumulates in the nucleus and binds to the transcription factor, TCF/Lef, to activate Wnt target gene transcription. In order for beta-catenin to bind TCF/Lef, however, the transcriptional corepressor Groucho (Gro)/TLE, which is bound to TCF/Lef, must be displaced. Work by Hanson et al. shows that X-linked Inhibitor of Apoptosis (XIAP), an E3 ubiquitin ligase,...
Developmental Biology Vol363-issue2
Mar. 19, 2012—Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors Abstract The enteric nervous system (ENS) arises from the coordinated migration, expansion and differentiation of vagal and sacral neural crest progenitor cells. During development, vagal neural crest cells enter the foregut and migrate in a rostro-to-caudal direction, colonizing the...
Tyska Lab demonstrate enterocyte microvilli-derived vesicles a novel form of defense
Mar. 12, 2012—Info: Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions David A. Shifrin, Jr., Russell E. McConnell, Rajalakshmi Nambiar, James N. Higginbotham, Robert J. Coffey, and Matthew J. Tyska Current Biology; April 10, 2012 Abstract: The continuous monolayer of intestinal epithelial cells (IECs) lining the gut lumen functions as the site of nutrient absorption...
Kaverina Lab centrosomal versus Golgi-derived microtubules
Mar. 12, 2012—Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not for maintenance Abstract Assembly of an integral Golgi complex is driven by microtubule (MT)-dependent transport. Conversely, the Golgi itself functions as an unconventional MT-organizing center (MTOC). This raises the question of whether Golgi assembly requires centrosomal MTs or can...
A zebrafish model of lethal congenital contracture syndrome
Mar. 12, 2012—In humans, GLE1 is mutated in lethal congenital contracture syndrome 1 (LCCS1) leading to prenatal death of all affected fetuses. Although the molecular roles of Gle1 in nuclear mRNA export and translation have been documented, no animal models for this disease have been reported. To elucidate the function of Gle1 in vertebrate development, we used...