News
Andrea Page-McCaw
Jun. 24, 2010—On July 1 this year Associate Professor Andrea Page–McCaw will join us. Andrea studies protease-mediated cell signaling and tissue remodeling in Drosophila, and comes to us from the Rensselaer Polytechnic Institute in NY. Andrea’s lab and office will be located in 4124 MRB III. Research Interests Protease-mediated cell-cell signaling and tissue remodeling in Drosophila During...
Notch Signaling regulates formation of the three-dimensional architecture
May. 18, 2010—Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice Erin E. Sparks 1, Kari A. Huppert 1, Melanie A. Brown 1, M. Kay Washington 2, Stacey S. Huppert 1 * 1Department of Cell and Developmental Biology and Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN 2Department of...
Heterotrimeric G proteins and beta-catenin/TCF signaling
May. 13, 2010—Sci. Signal., 11 May 2010 Vol. 3, Issue 121, p. ra37 [DOI: 10.1126/scisignal.2000647] RESEARCH Gβ Activates GSK3 to Promote LRP6-Mediated β-Catenin Transcriptional Activity Kristin K. Jernigan1*, Christopher S. Cselenyi1*, Curtis A. Thorne1, Alison J. Hanson1, Emilios Tahinci1, Nicole Hajicek2,3, William M. Oldham4, Laura A. Lee1, Heidi E. Hamm4, John R. Hepler5, Tohru Kozasa2,3, Maurine E....
Transventricular delivery of Sonic hedgehog
May. 7, 2010—Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development Xi Huanga, Jiang Liua, Tatiana Ketovaa, Jonathan T. Fleminga, Vandana K. Groverb, Michael K. Cooperb, Ying Litingtunga, and Chin Chianga,1 + Author Affiliations Departments of aCell and Developmental Biology and bNeurology, Center for Molecular Neuroscience, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center,...
P. Ohi lab’s first paper
Feb. 22, 2010—P.Ohi lab’s first paper hit the press today in Current Biology, this issue The Kinesin-8 Kif18A Dampens Microtubule Plus-End Dynamics Yaqing Du1, Chauca A. English1 and Ryoma Ohi 1 Department of Cell and DevelopmentalBiology, Vanderbilt University School of Medicine, 465 21st AvenueSouth, Nashville, TN 37232-8240, USA Received 2 June 2009; revised 1 December 2009; accepted...
Basic Science Leadership Changes
Dec. 29, 2009—Dear Colleagues, As 2009 comes to a close, I would like to take this opportunity to wish you well and to announce these important changes for senior leadership within the departments of Cell and Developmental Biology and Cancer Biology. These changes are effective January 1. First, I would like to address leadership changes within the...
golgi-derived-clasp-dependent-microtubules-control
Sep. 10, 2009—Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.
Chancellor’s Awards for Research
Sep. 10, 2009—Irina Kaverina and others, recognized with Chancellor’s Awards for Research, which recognizes excellence in research, scholarship or creative expression. Chancellor's Awards Page VUcast faculty assembly
Identifying a borealin component of the yeast chromosome passenger complex
Aug. 26, 2009—Identifying a borealin component of the yeast chromosome passenger complex.
Sonic hedgehog signaling regulates a novel epithelial progenitor
Aug. 25, 2009—Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C. Development. 2009 Aug;136(15):2535-43. Epub 2009 Jul 1. Note that VUMC reporter will do an aliquot report on this paper on August 14 2. Shh and Gli3 activities...
Microvilli give gut vesicles the brush-off
Jul. 31, 2009—A surprising new function for intestinal cells in shaping theirlocal environment.Every cell lining the small intestine bristles with thousandsof tightly packed microvilli that project into the gut lumen,forming a brush border that absorbs nutrients and protects thebody from intestinal bacteria. McConnell et al. now find thatmicrovilli extend their functional reach even further usinga molecular motor...
Chemicals turn human embryonic stem cells towards beta cells
Apr. 7, 2009—nature chemical biology 5, 195 – 196 (2009) doi:10.1038/nchembio0409-195 Yu-Ping Yang1 & Chris Wright1 Yu-Ping Yang and Chris Wright are in the Department of Cell and Developmental Biology and the Vanderbilt University Program in Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. e-mail: chris.wright@vanderbilt.edu Abstract Small-molecule library screening identifies simple imitators of the cellular...
Defining elements in contractile ring assembly
Mar. 27, 2009—Vanderbilt Reporter, Lords of the contractile ring Cell division requires the formation of a contractile ring. While many protein components of this ring are known, how they interact with each other and with the plasma membrane remains unclear. Rachel Roberts-Galbraith, Kathy Gould, Ph.D., and colleagues are studying these ring proteins in yeast. One such protein,...
Membrane Curvature’s Pore Relation
Mar. 20, 2009—ER membrane–bending proteins are necessary for de novo nuclear pore formation T. Renee Dawson1, Michelle D. Lazarus1, Martin W. Hetzer2, and Susan R. Wente1 1 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2 Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037 Correspondence to...
Cells cycle with no poles
Feb. 18, 2009—Cells cycle with no poles- no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila Julie A. Merkle1, Jamie L. Rickmyre1, Aprajita Garg2, Erin B. Loggins1, Jeanne N. Jodoin1, Ethan Lee1, Louisa P. Wu2 and Laura A. Lee1,* 1 Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U-4200...