PDB Journal Club

The Developmental Biology Journal Club (DBJC) is a weekly forum where program members can learn about and discuss recently published developmental biology-themed research findings.

Graduate students, postdoctoral fellows, and primary investigators all share presentation responsibilities. Once a member is chosen to present at the DBJC he or she must choose a topic outside his or her typical field of interest, adapt the article for a 30-40 minute PowerPoint presentation, and be prepared to discuss the work in a Q&A session afterwards.

Journal Club is a great way for less-established researchers to gain public speaking and question-and-answer experience in a collegial, non-stressful environment. Additionally, younger program members can learn staging and questioning skills from senior member DBJC presentations. Refreshments are always served and attendees are encouraged to continue their discussions after the seminar has ended.

Hello Program in Developmental Biology Members,

This week, Natalya Ortolano (Graduate Student, Gama Lab) will present the paper:

 "Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells," Toda et. al
Cell Stem Cell 2017 Nov 2; Volume 21, Issue 5

Toda et. al. demonstrate that the nuclear-pore protein Nup153 interacts with Sox2 promoting the transcriptional program of neural progenitor cells, and ultimately their maintenance. One important point is their determination that transcriptional regulation by the Nup153-Sox2 interaction is dependent on the position of Nup153 interaction on the gene. They demonstrate the relevance of Nup153 in neural progenitor properties both in vitro and in vivo. Ultimately, their findings support accumulating evidence that nucleoporins play an essential non-canonical role in transcription regulation and developmental programs.

We look forward to seeing you all there!

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