PDB Journal Club

The Developmental Biology Journal Club (DBJC) is a weekly forum where program members can learn about and discuss recently published developmental biology-themed research findings.

Graduate students, postdoctoral fellows, and primary investigators all share presentation responsibilities. Once a member is chosen to present at the DBJC he or she must choose a topic outside his or her typical field of interest, adapt the article for a 30-40 minute PowerPoint presentation, and be prepared to discuss the work in a Q&A session afterwards.

Journal Club is a great way for less-established researchers to gain public speaking and question-and-answer experience in a collegial, non-stressful environment. Additionally, younger program members can learn staging and questioning skills from senior member DBJC presentations. Refreshments are always served and attendees are encouraged to continue their discussions after the seminar has ended.

Hello Program in Developmental Biology Members

Please make a special effort to join us this Friday when Maulik Patel (Assistant Professor - Biological Sciences) will present the paper   “Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation". We will be meeting in 3131 MRB III at 4:00pm. We look forward to seeing you there.

"Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation,"
Tang H. and Han M., Cell 2017 Apr 20; 169 (3): 457-469

While sex determination can be under strict genetic control, in many organisms it can also be regulated by environment.  How environmental cues are sensed and coupled with the sex determination machinery is poorly understood.  Using hermaphroditic C. elegans, Tang and Han show that fatty acids modulate the switch from sperm development to oocyte production.  Myristoyl-CoA from fatty acid metabolism in intestinal cells is used to myristoylate proteins in the germline, which in turn modulates activity of mpk-1, a known regulator of the sex-determination pathway.  The study provides a mechanistic link between the nutritional environment and sex determination. 

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