MSTPublications: November 2024
Sexual Trauma, Polygenic Scores, and Mental Health Diagnoses and Outcomes.
Lake AM, Zhou Y, Wang B, Actkins KV, Zhang Y, Shelley JP, Rajamani A, Steigman M, Kennedy CJ, Smoller JW, Choi KW, Khankari NK, Davis LK.
JAMA Psychiatry. 2024 Oct 30. doi: 10.1001/jamapsychiatry.2024.3426. Online ahead of print.
PMID: 39475956
Importance: Leveraging real-world clinical biobanks to investigate the associations between genetic and environmental risk factors for mental illness may help direct clinical screening efforts and evaluate the portability of polygenic scores across environmental contexts.
Objective: To examine the associations between sexual trauma, polygenic liability to mental health outcomes, and clinical diagnoses of schizophrenia, bipolar disorder, and major depressive disorder in a clinical biobank setting.
Design, setting, and participants: This genetic association study was conducted using clinical and genotyping data from 96 002 participants across hospital-linked biobanks located at Vanderbilt University Medical Center (VUMC), Nashville, Tennessee (including 58 262 individuals with high genetic similarity to the 1000 Genomes Project [1KG] Northern European from Utah reference population [1KG-EU-clustered] and 11 047 with high genetic similarity to the 1KG African-ancestry reference population of Yoruba in Ibadan, Nigeria [1KG-YRI-clustered]), and Mass General Brigham (MGB), Boston, Massachusetts (26 693 individuals with high genetic similarity to the combined European-ancestry superpopulation [1KG-EU-clustered]). Clinical data analyzed included diagnostic billing codes and clinical notes spanning from 1976 to 2023. Data analysis was performed from 2022 to 2024.
Exposures: Clinically documented sexual trauma disclosures and polygenic scores for schizophrenia, bipolar disorder, and major depressive disorder.
Main outcomes and measures: Diagnoses of schizophrenia, bipolar disorder, and major depressive disorder, determined by aggregating related diagnostic billing codes, were the dependent variables in logistic regression models including sexual trauma disclosure status, polygenic scores, and their interactions as the independent variables.
Results: Across the VUMC and MGB biobanks, 96 002 individuals were included in analyses (VUMC 1KG-EU-clustered: 33 011 [56.7%] female; median [range] age, 56.8 [10.0 to >89] years; MGB 1KG-EU-clustered: 14 647 [54.9%] female; median [range] age, 58.0 [10.0 to >89] years; VUMC 1KG-YRI-clustered: 6961 [63.0%] female; median [range] age, 44.6 [10.1 to >89] years). Sexual trauma history was associated with all mental health conditions across institutions (ORs ranged from 8.83 [95% CI, 5.50-14.18] for schizophrenia in the VUMC 1KG-YRI-clustered cohort to 17.65 [95% CI, 12.77-24.40] for schizophrenia in the VUMC 1KG-EU-clustered cohort). Sexual trauma history and polygenic scores jointly explained 3.8% to 8.8% of mental health phenotypic variance. Schizophrenia and bipolar disorder polygenic scores had greater associations with mental health outcomes in individuals with no documented disclosures of sexual trauma (schizophrenia interaction: OR, 0.70 [95% CI, 0.56-0.88]; bipolar disorder interaction: OR, 0.83 [95% CI, 0.74-0.94]).
Conclusions and relevance: Sexual trauma and mental health polygenic scores, while correlated with one another, were independent and joint risk factors for severe mental illness in a large, diverse hospital biobank population. Furthermore, associations of schizophrenia and bipolar disorder polygenic scores with respective diagnoses were greater in those without disclosures, suggesting that genetic predisposition to mental illness as measured by polygenic scores may be less impactful in the presence of this severe environmental risk factor.
Allie’s publication is highlighted here in VUMC News https://news.vumc.org/2024/10/30/genetic-risk-sexual-trauma-associated-with-mental-illness-study!
Germline genetics, disease, and exposure to medication influence longitudinal dynamics of clonal hematopoiesis.
Mack T*, Pershad Y*, Vlasschaert C, Bejan CA, Heimlich JB, Li Y, Mickels NA, Van Amburg JC, Ulloa J, Silver AJ, Luo LY, Jones A, Ferrell PB, Kishtagari A, Xu Y, Savona MR, Bick AG.
*contributed equally
Haematologica. 2024 Nov 14. doi: 10.3324/haematol.2024.286513. Online ahead of print.
PMID: 39540221 Free article.
Super-resolution multi-contrast unbiased eye atlases with deep probabilistic refinement.
Lee HH, Saunders AM, Kim ME, Remedios SW, Remedios LW, Tang Y, Yang Q, Yu X, Bao S, Cho C, Mawn LA, Rex TS, Schey KL, Dewey BE, Spraggins JM, Prince JL, Huo Y, Landman BA.
J Med Imaging (Bellingham). 2024 Nov;11(6):064004. doi: 10.1117/1.JMI.11.6.064004. Epub 2024 Nov 14.
Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics.
Parker AC, Van Amburg J, Heimlich JB, Pershad Y, Mickels NA, Mack T, Ferrell PB Jr, Savona MR, Jones A, Bick AG.
Blood. 2024 Nov 20:blood.2024026555. doi: 10.1182/blood.2024026555. Online ahead of print.
Endogenous Glucagon-Like Peptide-1 Receptor and Glucose-Dependent Insulinotropic Polypeptide Receptor Signaling Inhibits Aeroallergen-Induced Innate Airway Inflammation.
Toki S, Abney M, Zhang J, Rusznak M, Warren CM, Newcomb DC, Cahill KN, Drucker DJ, Niswender KD, Peebles RS Jr.
Allergy. 2024 Nov 19. doi: 10.1111/all.16402. Online ahead of print.
Data-driven nucleus subclassification on colon hematoxylin and eosin using style-transferred digital pathology.Remedios LW, Bao S, Remedios SW, Lee HH, Cai LY, Li T, Deng R, Newlin NR, Saunders AM, Cui C, Li J, Liu Q, Lau KS, Roland JT, Washington MK, Coburn LA, Wilson KT, Huo Y, Landman BA.
J Med Imaging (Bellingham). 2024 Nov;11(6):067501. doi: 10.1117/1.JMI.11.6.067501. Epub 2024 Nov 5.
PMID: 39507410
Adverse effects of CXCR2 deficiency in mice reared under non-gnotobiotic conditions.
Garcia MJ, Morales MS, Yang TS, Holden J, Bossardet OL, Palmer SA, Jhala M, Priest S, Namburu N, Beatty N, D’Empaire Salomon SE, Vancel J, Wareham LK, Padovani-Claudio DA.
Sci Rep. 2024 Oct 30;14(1):26159. doi: 10.1038/s41598-024-75532-9.
PMID: 39478033 Free PMC article.
Out of the ice age: Preservation of cardiac allografts with a reusable 10 °C cooler.
Trahanas JM, Harris T, Petrovic M, Dreher A, Pasrija C, DeVries SA, Bommareddi S, Lima B, Wang CC, Cortelli M, Fortier A, Tracy K, Simonds E, Keck CD, Scholl SR, Siddiqi H, Schlendorf K, Bacchetta M, Shah AS.
JTCVS Open. 2024 Aug 21;21:197-209. doi: 10.1016/j.xjon.2024.08.005. eCollection 2024 Oct.
PMID: 39534335 Free PMC article.
Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin 2.
Carty JS, Bessho R, Zuchowski Y, Trapani JB, Davidoff O, Kobayashi H, Roland JT, Watts JA, Terker AS, Bock F, Arroyo JP, Haase VH.
JCI Insight. 2024 Nov 22;9(22):e182087. doi: 10.1172/jci.insight.182087.
Barriers to Cochlear Implant Uptake in Adults: A Scoping Review.
Neukam JD, Kunnath AJ, Patro A, Gifford RH, Haynes DS, Moberly AC, Tamati TN.
Otol Neurotol. 2024 Dec 1;45(10):e679-e686. doi: 10.1097/MAO.0000000000004340.
PMID: 39514420 Review.
Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Health.
Raddatz MA, Pershad Y, Parker AC, Bick AG.
Cardiol Clin. 2025 Feb;43(1):13-23. doi: 10.1016/j.ccl.2024.08.004. Epub 2024 Oct 2.
PMID: 39551555 Review.
How auditory processing influences the autistic profile: A review.
Poulsen R, Williams Z, Dwyer P, Pellicano E, Sowman PF, McAlpine D.
Autism Res. 2024 Nov 17. doi: 10.1002/aur.3259. Online ahead of print.
PMID: 39552096 Review.
VISTA-mediated immune evasion in cancer.
Zhang RJ, Kim TK.
Exp Mol Med. 2024 Nov 1. doi: 10.1038/s12276-024-01336-6. Online ahead of print.
PMID: 39482534 Free article. Review.