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MSTPublications: July 2020

Jul. 28, 2020—Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci. LaBella AL*, Abraham A*, Pichkar Y, Fong SL, Zhang G, Muglia LJ, Abbot P, Rokas A, Capra JA. Nat Commun. 2020 Jul 24;11(1):3731. doi: 10.1038/s41467-020-17258-6. PMID: 32709900 Currently, there is no comprehensive framework to evaluate the evolutionary forces acting on...

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MSTPublications: June 2020

Jun. 25, 2020—DEPDC5 haploinsufficiency drives increased mTORC1 signaling and abnormal morphology in human iPSC-derived cortical neurons. Klofas LK, Short BP, Snow JP, Sinnaeve J, Rushing GV, Westlake G, Weinstein W, Ihrie RA, Ess KC, Carson RP. Neurobiol Dis. 2020 Jun 20:104975. doi: 10.1016/j.nbd.2020.104975. [Epub ahead of print] Mutations in the DEPDC5 gene can cause epilepsy, including forms...

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MSTPublications: May 2020

May. 20, 2020—Cerebrospinal fluid biomarkers of neurodegeneration, synaptic dysfunction, and axonal injury relate to atrophy in structural brain regions specific to Alzheimer’s disease. Moore EE, Gifford KA, Khan OA, Liu D, Pechman KR, Acosta LMY, Bell SP, Turchan M, Landman BA, Blennow K, Zetterberg H, Hohman TJ, Jefferson AL. Alzheimers Dement. 2020 May 6. doi: 10.1002/alz.12087. [Epub...

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MSTPublications: April 2020

Apr. 29, 2020—Expanding cultural and ancestral representation in psychiatric genetic studies. Kang J, Ruderfer DM. Neuropsychopharmacology. 2020 Apr 15. doi: 10.1038/s41386-020-0676-1. [Epub ahead of print] No abstract available.            Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1. Klofas LK, Short BP, Zhou C, Carson RP....

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MSTPublications: March 2020

Mar. 29, 2020—Lipopolysaccharide Induced Opening of the Blood Brain Barrier on Aging 5XFAD Mouse Model. Barton SM, Janve VA, McClure R, Anderson A, Matsubara JA, Gore JC, Pham W. J Alzheimers Dis. 2019;67(2):503-513. doi: 10.3233/JAD-180755. The development of neurotherapeutics for many neurodegenerative diseases has largely been hindered by limited pharmacologic penetration across the blood-brain barrier (BBB). Previous...

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MSTPublications: January 2020

Jan. 30, 2020—Analysis of Non-Human Primate Pancreatic Islet Oxygen Consumption. Elsakr JM, Deeter C, Ricciardi V, Gannon M. J Vis Exp. 2019 Dec 18;(154). doi: 10.3791/60696. The measurement of oxygen consumption in spheroid clusters of cells, such as ex vivo pancreatic islets, has historically been challenging. We demonstrate the measurement of islet oxygen consumption using a 96-well...

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MSTPublications: December 2019

Dec. 19, 2019—Specific Molecular Recognition as a Strategy to Delineate Tumor Margin Using Topically Applied Fluorescence Embedded Nanoparticles. Barton S, Li B, Siuta M, Vaibhav J, Song J, Holt CM, Tomono T, Ukawa M, Kumagai H, Tobita E, Wilson K, Sakuma S, Pham W. Precis Nanomed. 2018 Nov 25;1(3):194-207. doi: 10.33218/prnano1(3).181009.1. Epub 2018 Oct 29. The Thomsen-Friedenreich...

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MSTPublications: October 2019

Oct. 29, 2019—Towards Machine Learning Prediction of Deep Brain Stimulation (DBS) Intra-operative Efficacy Maps. Bermudez C, Rodriguez W, Huo Y, Hainline AE, Li R, Shults R, D’Haese PD, Konrad PE, Dawant BM, Landman BA. Proc SPIE Int Soc Opt Eng. 2019 Mar;10949. pii: 1094922. doi: 10.1117/12.2509728. Deep brain stimulation (DBS) has the potential to improve the quality...

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MSTPublications: September 2019

Sep. 27, 2019—The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 provides a unique essential function in maintenance of cytokinetic ring integrity. Mangione MC, Snider CE, Gould KL. Mol Biol Cell. 2019 Sep 11:mbcE19060314. doi: 10.1091/mbc.E19-06-0314. [Epub ahead of print] Successful separation of two daughter cells (i.e. cytokinesis) is essential for life. Many eukaryotic cells divide...

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MSTPublications: August 2019

Aug. 27, 2019—Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. Dudzinski SO, Cameron BD, Wang J, Rathmell JC, Giorgio TD, Kirschner AN. J Immunother Cancer. 2019 Aug 14;7(1):218. doi: 10.1186/s40425-019-0704-z. Background: Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance...

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