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MSTPublications: August 2019

Aug. 27, 2019—Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. Dudzinski SO, Cameron BD, Wang J, Rathmell JC, Giorgio TD, Kirschner AN. J Immunother Cancer. 2019 Aug 14;7(1):218. doi: 10.1186/s40425-019-0704-z. Background: Prostate cancer is poorly responsive to immune checkpoint inhibition, yet a combination with radiotherapy may enhance...

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MSTPublications: July 2019

Jul. 30, 2019—Anatomical context improves deep learning on the brain age estimation task. Bermudez C, Plassard AJ, Chaganti S, Huo Y, Aboud KE, Cutting LE, Resnick SM, Landman BA. Magn Reson Imaging. 2019 Jun 24. pii: S0730-725X(18)30609-X. doi: 10.1016/j.mri.2019.06.018. [Epub ahead of print] Deep learning has shown remarkable improvements in the analysis of medical images without the...

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MSTPublications: June 2019

Jun. 25, 2019—p73 regulates epidermal wound healing and induced keratinocyte programming. Beeler JS, Marshall CB, Gonzalez-Ericsson PI, Shaver TM, Santos Guasch GL, Lea ST, Johnson KN, Jin H, Venters BJ, Sanders ME, Pietenpol JA. PLoS One. 2019 Jun 19;14(6):e0218458. doi: 10.1371/journal.pone.0218458. eCollection 2019. p63 is a transcriptional regulator of ectodermal development that is required for basal cell...

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MSTPublications: May 2019

May. 30, 2019—Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. DiCarlo GE, Aguilar JI, Matthies HJ, Harrison FE, Bundschuh KE, West A, Hashemi P, Herborg F, Rickhag M, Chen H, Gether U, Wallace MT, Galli A. J Clin Invest. 2019 May 16;130. pii: 127411. doi: 10.1172/JCI127411. The precise regulation of synaptic dopamine (DA) content...

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MSTPublications: April 2019

Apr. 29, 2019—Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli. Beebout CJ, Eberly AR, Werby SH, Reasoner SA, Brannon JR, De S, Fitzgerald MJ, Huggins MM, Clayton DB, Cegelski L, Hadjifrangiskou M. MBio. 2019 Apr 2;10(2). pii: e02400-18. doi: 10.1128/mBio.02400-18. Biofilms are multicellular bacterial communities encased in a self-secreted extracellular matrix comprised of...

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MSTPublications: March 2019

Mar. 28, 2019—J-N Gallant’s recent first-author paper was featured here in the VUMC Reporter!   Katherine Konvinse’s recent first-author paper was featured here in the VUMC Reporter!   Applied Bioengineering in Tissue Reconstruction, Replacement, and Regeneration. Colazo JM, Evans BC, Farinas AF, Al-Kassis S, Duvall C, Thayer WP. Tissue Eng Part B Rev. 2019 Mar 21. doi:...

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Training the Physician-Scientist: Views from Program Directors and Aspiring Young Investigators

Feb. 26, 2019—Read MSTP Director Christopher Williams, MD, PhD‘s Op-Ed published recently in JCI Insight. Training the physician-scientist: views from program directors and aspiring young investigators. Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata...

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Recent Op-Eds by Members of the MSTP

Feb. 26, 2019—Members of our program recently contributed to the following Op-Eds about Medical Education:   Training the physician-scientist: views from program directors and aspiring young investigators by MSTP Director Christopher Williams, M.D., Ph.D.   Getting Our Priorities Right: Social Determinants of Health in Medical Education by Michael Raddatz (G2)   Student Perspectives on the “Step 1 Climate”...

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MSTPublications: February 2019

Feb. 26, 2019—On-target resistance to the mutant-selective EGFR inhibitor osimertinib can develop in an allele specific manner dependent on the original EGFR activating mutation. Brown BP, Zhang YK, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA,  Ali SM, Bazhenova L, Schrock AB, Meiler J, Lovly CM. Clin Cancer Res....

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MSTPublications: January 2019

Jan. 21, 2019—Smarcal1 and Zranb3 protect replication forks from Myc-induced DNA replication stress. Puccetti MV, Adams CM, Kushinsky S, Eischen CM. Cancer Res. 2019 Jan 4. pii: canres.2705.2018. doi: 10.1158/0008-5472.CAN-18-2705. [Epub ahead of print] The cellular DNA replication stress response functions to stabilize DNA replication forks and inhibit genome instability and tumorigenesis induced by oncogenes. However, the...

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