New Publications
MSTPublications: August 2021
Aug. 30, 2021—Machine Learning Prediction of Kidney Stone Composition Using Electronic Health Record-Derived Features. Abraham A, Kavoussi N, Sui W, Bejan C, Capra JA, Hsi R. J Endourol. 2021 Jul 27. doi: 10.1089/end.2021.0211. Online ahead of print. Aims: Noninvasive prediction of kidney stone composition could direct dietary and pharmacologic preventative treatment without stone analysis. We aimed to assess the...
MSTPublications: July 2021
Jul. 28, 2021—Elizabeth Moore’s recent first-author paper was featured here in the VUMC Reporter! MASiVar: Multisite, multiscanner, and multisubject acquisitions for studying variability in diffusion weighted MRI. Cai LY, Yang Q, Kanakaraj P, Nath V, Newton AT, Edmonson HA, Luci J, Conrad BN, Price GR, Hansen CB, Kerley CI, Ramadass K, Yeh FC, Kang H, Garyfallidis E, Descoteaux M, Rheault F, Schilling...
MSTPublications: June 2021
Jun. 25, 2021—Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model. Elsakr JM, Zhao SK, Ricciardi V, Dean TA, Takahashi DL, Sullivan E, Wesolowski SR, McCurdy CE, Kievit P, Friedman JE, Aagaard KM, Edwards DRV, Gannon M. Sci Rep. 2021 Jun 21;11(1):12977. doi: 10.1038/s41598-021-92464-w. The prevalence of maternal obesity...
MSTPublications: May 2021
May. 24, 2021—Safety and efficacy of genetic MECP2 supplementation in the R294X mouse model of Rett syndrome. Collins BE, Merritt JK, Erickson KR, Neul JL. Genes Brain Behav. 2021 May 3:e12739. doi: 10.1111/gbb.12739. Online ahead of print. PMID: 33942492 Rett syndrome is a neurodevelopmental disorder caused predominantly by loss-of-function mutations in MECP2, encoding transcriptional modulator methyl-CpG-binding protein...
MSTPublications: April 2021
Apr. 30, 2021—Cytochrome bd promotes Escherichia coli biofilm antibiotic tolerance by regulating accumulation of noxious chemicals. Beebout CJ, Sominsky LA, Eberly AR, Van Horn GT, Hadjifrangiskou M. NPJ Biofilms Microbiomes. 2021 Apr 16;7(1):35. doi: 10.1038/s41522-021-00210-x. Nutrient gradients in biofilms cause bacteria to organize into metabolically versatile communities capable of withstanding threats from external agents including bacteriophages, phagocytes,...
MSTPublications: March 2021
Mar. 30, 2021—Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting. Du Z*, Brown BP*, Kim S, Ferguson D, Pavlick DC, Jayakumaran G, Benayed R, Gallant JN, Zhang YK, Yan Y, Red-Brewer M, Ali SM, Schrock AB, Zehir A, Ladanyi M, Smith AW, Meiler J, Lovly CM....
MSTPublications: February 2021
Feb. 24, 2021—General Purpose Structure-Based Drug Discovery Neural Network Score Functions with Human-Interpretable Pharmacophore Maps. Brown BP, Mendenhall J, Geanes AR, Meiler J. J Chem Inf Model. 2021 Jan 26. doi: 10.1021/acs.jcim.0c01001. Online ahead of print. The BioChemical Library (BCL) is an academic open-source cheminformatics toolkit comprising ligand-based virtual high-throughput screening (vHTS) tools such as quantitative structure-activity/property...
MSTPublications: January 2021
Jan. 28, 2021—Generalizing deep whole-brain segmentation for post-contrast MRI with transfer learning. Bermudez C, Remedios SW, Ramadass K, McHugo M, Heckers S, Huo Y, Landman BA. J Med Imaging (Bellingham). 2020 Nov;7(6):064004. doi: 10.1117/1.JMI.7.6.064004. Epub 2020 Dec 23. PMID: 33381612 Purpose: Generalizability is an important problem in deep neural networks, especially with variability of data acquisition in...
MSTPublications: December 2020
Dec. 18, 2020—Diflunisal-loaded poly(propylene sulfide) nanoparticles decrease S. aureus-mediated bone destruction during osteomyelitis. Ford CA, Spoonmore TJ, Gupta MK, Duvall CL, Guelcher SA, Cassat JE. J Orthop Res. 2020 Dec 10. doi: 10.1002/jor.24948. Online ahead of print. Osteomyelitis is a debilitating infection of bone that results in substantial morbidity. Staphylococcus aureus is the most commonly isolated pathogen...
MSTPublications: November 2020
Nov. 23, 2020—Safety of Hydroxychloroquine Among Outpatient Clinical Trial Participants for COVID-19. Lofgren SM, Nicol MR, Bangdiwala AS, Pastick KA, Okafor EC, Skipper CP, Pullen MF, Engen NW, Abassi M, Williams DA, Nascene AA, Axelrod ML, Lother SA, MacKenzie LJ, Drobot G, Marten N, Cheng MP, Zarychanski R, Schwartz IS, Silverman M, Chagla Z, Kelly LE, McDonald...