New Publications
MSTPublications: March 2022
Apr. 4, 2022—Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery. Brown BP, Vu O, Geanes AR, Kothiwale S, Butkiewicz M, Lowe EW Jr, Mueller R, Pape R, Mendenhall J, Meiler J. Front Pharmacol. 2022 Feb 21;13:833099. doi: 10.3389/fphar.2022.833099. eCollection 2022. The BioChemical Library (BCL) cheminformatics...
MSTPublications: February 2022
Feb. 25, 2022—Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension. Wu P, Feng Q, Kerchberger VE, Nelson SD, Chen Q, Li B, Edwards TL, Cox NJ, Phillips EJ, Stein CM, Roden DM, Denny JC, Wei WQ. Nat Commun. 2022 Jan 10;13(1):46. doi: 10.1038/s41467-021-27751-1. Discovering novel uses for existing drugs, through...
MSTPublications: January 2022
Jan. 29, 2022—HDAC inhibitors stimulate LIFR when it is repressed by hypoxia or PTHrP in breast cancer. Edwards CM, Clements ME, Vecchi LA 3rd, Johnson JA, Johnson RW. J Bone Oncol. 2021 Dec 1;31:100407. doi: 10.1016/j.jbo.2021.100407. eCollection 2021 Dec. Breast cancer cells frequently disseminate to the bone marrow, where they either induce osteolysis or enter a dormant...
MSTPublications: December 2021
Dec. 20, 2021—MTG16 (CBFA2T3) regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors Rachel E. Brown, Justin Jacobse, Shruti A. Anant, Koral M. Blunt, Bob Chen, Paige N. Vega, Chase T. Jones, Jennifer M. Pilat, Frank Revetta, Aidan H. Gorby, Kristy R. Stengel, Yash A. Choksi, Kimmo Palin, M. Blanca Piazuelo, M. Kay...
MSTPublications: November 2021
Nov. 30, 2021— Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages. Dudzinski SO, Bader JE, Beckermann KE, Young KL, Hongo R, Madden MZ, Abraham A, Reinfeld BE, Ye X, MacIver NJ, Giorgio TD, Rathmell JC. J Immunol. 2021 Nov 12:ji2001152. doi: 10.4049/jimmunol.2001152. Online ahead of print. Although obesity can promote cancer, it may also...
MSTPubs: September 2021
Sep. 30, 2021—Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage. Bedingfield, SK, Colazo, JM, Yu, F. et al. Nat Biomed Eng. 2021 Aug 19. https://doi.org/10.1038/s41551-021-00780-3 The progression of osteoarthritis is associated with inflammation triggered by the enzymatic degradation of extracellular matrix in injured cartilage. Here we show that a locally injected...
MSTPublications: August 2021
Aug. 30, 2021—Machine Learning Prediction of Kidney Stone Composition Using Electronic Health Record-Derived Features. Abraham A, Kavoussi N, Sui W, Bejan C, Capra JA, Hsi R. J Endourol. 2021 Jul 27. doi: 10.1089/end.2021.0211. Online ahead of print. Aims: Noninvasive prediction of kidney stone composition could direct dietary and pharmacologic preventative treatment without stone analysis. We aimed to assess the...
MSTPublications: July 2021
Jul. 28, 2021—Elizabeth Moore’s recent first-author paper was featured here in the VUMC Reporter! MASiVar: Multisite, multiscanner, and multisubject acquisitions for studying variability in diffusion weighted MRI. Cai LY, Yang Q, Kanakaraj P, Nath V, Newton AT, Edmonson HA, Luci J, Conrad BN, Price GR, Hansen CB, Kerley CI, Ramadass K, Yeh FC, Kang H, Garyfallidis E, Descoteaux M, Rheault F, Schilling...
MSTPublications: June 2021
Jun. 25, 2021—Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model. Elsakr JM, Zhao SK, Ricciardi V, Dean TA, Takahashi DL, Sullivan E, Wesolowski SR, McCurdy CE, Kievit P, Friedman JE, Aagaard KM, Edwards DRV, Gannon M. Sci Rep. 2021 Jun 21;11(1):12977. doi: 10.1038/s41598-021-92464-w. The prevalence of maternal obesity...
MSTPublications: May 2021
May. 24, 2021—Safety and efficacy of genetic MECP2 supplementation in the R294X mouse model of Rett syndrome. Collins BE, Merritt JK, Erickson KR, Neul JL. Genes Brain Behav. 2021 May 3:e12739. doi: 10.1111/gbb.12739. Online ahead of print. PMID: 33942492 Rett syndrome is a neurodevelopmental disorder caused predominantly by loss-of-function mutations in MECP2, encoding transcriptional modulator methyl-CpG-binding protein...