David Haas, M.D.
Professor of Medicine
- : david.haas@vanderbilt.edu
- : (615) 467-0154
- :
Vanderbilt Health - One Hundred Oaks
719 Thompson Lane, Suite 47183
Nashville, Tennessee - 37204
David Haas is an accomplished HIV clinical trialist and leader in human pharmacogenomic research relevant to HIV infection and its therapy. He has led the design and implementation of dozens of HIV clinical trials since 1994, both single site studies and multicenter projects. He established and has led the AIDS Clinical Trials Group (ACTG) Clinical Research Site at Vanderbilt since its inception. He previously chaired the Pharmacology Committee for the AIDS Clinical Trials Group (ACTG), has led the ACTG’s pharmacogenomics program since 2000, and in 2011 was elected to serve on the ACTG Executive Committee.
Research Description
David Haas is an accomplished HIV clinical trialist and leader in human pharmacogenomic research relevant to HIV infection and its therapy. He has led the design and implementation of dozens of HIV clinical trials since 1994, both single site studies and multicenter projects. He established and has led the AIDS Clinical Trials Group (ACTG) Clinical Research Site at Vanderbilt since its inception. He previously chaired the Pharmacology Committee for the AIDS Clinical Trials Group (ACTG), has led the ACTG’s pharmacogenomics program since 2000, and in 2011 was elected to serve on the ACTG Executive Committee. He oversaw the establishment of the ACTG Human DNA Repository, and is now extending DNA banking to non-US ACTG sites in resource-limited countries in worldwide. His work with the ACTG led to the seminal observation that a frequent CYP2B6 polymorphism predicts delayed clearance of efavirenz, which largely explains increased plasma exposure among individuals of African descent, and may help predict CNS side effects and virologic response. He is PI of a substantial, collaborative, multidisciplinary R01 entitled “Pharmacogenomics of HIV Therapyâ€. He is highly engaged in collaborative, multidisciplinary research with an emphasis on the importance of human genomics for antiretroviral disposition, efficacy, and toxicity. This is complemented on his extensive work on designing and implementing prospective clinical trials.
Selected Publications
-
Leger P, Chirwa S, Turner M, Richardson DM, Baker P, Leonard M, Erdem H, Olson L, Haas DW. Pharmacogenetics of efavirenz discontinuation for reported central nervous system symptoms appears to differ by race. Pharmacogenet. Genomics. 2016 Oct; 26(10): 473-80. PMID: 27509478, PMCID: PMC5014672, DOI: 10.1097/FPC.0000000000000238, ISSN: 1744-6880.
-
Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL. Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans. AIDS. 2016 Jul 7/17/2016; 30(11): 1807-15. PMID: 27088321, PMCID: PMC4925250, DOI: 10.1097/QAD.0000000000001124, ISSN: 1473-5571.
-
Castillo-Mancilla JR, Aquilante CL, Wempe MF, Smeaton LM, Firnhaber C, LaRosa AM, Kumarasamy N, Andrade A, Baheti G, Fletcher CV, Campbell TB, Haas DW, MaWhinney S, Anderson PL. Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342). J. Antimicrob. Chemother [print-electronic]. 2016 Jun; 71(6): 1609-18. PMID: 26892777, PMCID: PMC4867099, PII: dkw005, DOI: 10.1093/jac/dkw005, ISSN: 1460-2091.
-
Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW, . Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing. Clin. Pharmacol. Ther [print-electronic]. 2016 Apr; 99(4): 363-9. PMID: 26417955, PMCID: PMC4785051, DOI: 10.1002/cpt.269.
-
Hoffmann CJ, Cohn S, Mashabela F, Hoffmann JD, McIlleron H, Denti P, Haas DW, Dooley KE, Martinson NA, Chaisson RE. Treatment Failure, Drug Resistance, and CD4 T-Cell Count Decline Among Postpartum Women on Antiretroviral Therapy in South Africa. J. Acquir. Immune Defic. Syndr. 2016 Jan 1/1/2016; 71(1): 31-7. PMID: 26334739, PMCID: PMC4713347, DOI: 10.1097/QAI.0000000000000811, ISSN: 1944-7884.
-
Sinxadi PZ, McIlleron HM, Dave JA, Smith PJ, Levitt NS, Haas DW, Maartens G. Plasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations. Medicine (Baltimore). 2016 Jan; 95(2): e2385. PMID: 26765416, PMCID: PMC4718242, PII: 00005792-201601120-00023, DOI: 10.1097/MD.0000000000002385, ISSN: 1536-5964.
-
Schackman BR, Haas DW, Park SS, Li XC, Freedberg KA. Cost-effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice. Pharmacogenomics [print-electronic]. 2015 Dec; 16(18): 2007-18. PMID: 26607811, PMCID: PMC4832977, DOI: 10.2217/pgs.15.142, ISSN: 1744-8042.
-
McLaren PJ, Coulonges C, Bartha I, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington MN, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, Poli G, Sandhu MS, Schuitemaker H, Shea PR, Theodorou I, Walker BD, Weintrob AC, Winkler CA, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PI, Zagury JF, Fellay J. Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2015 Nov 11/24/2015; 112(47): 14658-63. PMID: 26553974, PMCID: PMC4664299, PII: 1514867112, DOI: 10.1073/pnas.1514867112, ISSN: 1091-6490.
-
Vardhanabhuti S, Ribaudo HJ, Landovitz RJ, Ofotokun I, Lennox JL, Currier JS, Olson LM, Haas DW. Screening for UGT1A1 Genotype in Study A5257 Would Have Markedly Reduced Premature Discontinuation of Atazanavir for Hyperbilirubinemia. Open Forum Infect Dis. 2015 Sep; 2(3): ofv085. PMID: 26180834, PMCID: PMC4498287, PII: ofv085, DOI: 10.1093/ofid/ofv085.
-
Wanga V, Venuto C, Morse GD, Acosta EP, Daar ES, Haas DW, Li C, Shepherd BE. Genomewide association study of tenofovir pharmacokinetics and creatinine clearance in AIDS Clinical Trials Group protocol A5202. Pharmacogenet. Genomics. 2015 Sep; 25(9): 450-61. PMID: 26148204, PMCID: PMC4522226, DOI: 10.1097/FPC.0000000000000156, ISSN: 1744-6880.
-
Sinxadi PZ, Leger PD, McIlleron HM, Smith PJ, Dave JA, Levitt NS, Maartens G, Haas DW. Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa. Br J Clin Pharmacol [print-electronic]. 2015 Jul; 80(1): 146-56. PMID: 25611810, PMCID: PMC4500334, DOI: 10.1111/bcp.12590, ISSN: 1365-2125.
-
Luetkemeyer AF, Rosenkranz SL, Lu D, Grinsztejn B, Sanchez J, Ssemmanda M, Sanne I, McIlleron H, Havlir DV, Haas DW, . Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study. Clin. Infect. Dis [print-electronic]. 2015 Jun 6/15/2015; 60(12): 1860-3. PMID: 25722197, PMCID: PMC4542662, PII: civ155, DOI: 10.1093/cid/civ155, ISSN: 1537-6591.
-
Lehmann DS, Ribaudo HJ, Daar ES, Gulick RM, Haubrich RH, Robbins GK, de Bakker PI, Haas DW, McLaren PJ. Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols. Pharmacogenet. Genomics. 2015 Feb; 25(2): 51-9. PMID: 25461247, PMCID: PMC4387236, DOI: 10.1097/FPC.0000000000000106, ISSN: 1744-6880.
-
Dooley KE, Denti P, Martinson N, Cohn S, Mashabela F, Hoffmann J, Haas DW, Hull J, Msandiwa R, Castel S, Wiesner L, Chaisson RE, McIlleron H, . Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection. J. Infect. Dis [print-electronic]. 2015 Jan 1/15/2015; 211(2): 197-205. PMID: 25081933, PMCID: PMC4334832, PII: jiu429, DOI: 10.1093/infdis/jiu429, ISSN: 1537-6613.
-
Dooley KE, Savic RM, Park JG, Cramer Y, Hafner R, Hogg E, Janik J, Marzinke MA, Patterson K, Benson CA, Hovind L, Dorman SE, Haas DW, . Novel dosing strategies increase exposures of the potent antituberculosis drug rifapentine but are poorly tolerated in healthy volunteers. Antimicrob. Agents Chemother [print-electronic]. 2015; 59(6): 3399-405. PMID: 25824215, PMCID: PMC4432148, PII: AAC.05128-14, DOI: 10.1128/AAC.05128-14, ISSN: 1098-6596.
-
Moore CB, Verma A, Pendergrass S, Verma SS, Johnson DH, Daar ES, Gulick RM, Haubrich R, Robbins GK, Ritchie MD, Haas DW. Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols. Open Forum Infect Dis. 2015 Jan; 2(1): ofu113. PMID: 25884002, PMCID: PMC4396430, PII: ofu113, DOI: 10.1093/ofid/ofu113.
-
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AA, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Mateo Leach I, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, De Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney AS, Dörr M, Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Gräßler J, Grönberg H, de Groot LC, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson Å, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PK, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, van der Velde N, van Heemst D, van Oort FV, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boomsma DI, Bornstein SR, Bovet P, Brambilla P, Brown MJ, Campbell H, Caulfield MJ, Chakravarti A, Collins R, Collins FS, Crawford DC, Cupples LA, Danesh J, de Faire U, den Ruijter HM, Erbel R, Erdmann J, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Gansevoort RT, Gejman PV, Gieger C, Golay A, Gottesman O, Gudnason V, Gyllensten U, Haas DW, Hall AS, Harris TB, Hattersley AT, Heath AC, Hengstenberg C, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Jacobs KB, Jarvelin MR, Jousilahti P, Jula AM, Kaprio J, Kastelein JJ, Kayser M, Kee F, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kooner JS, Kooperberg C, Koskinen S, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lupoli S, Madden PA, Männistö S, Manunta P, Marette A, Matise TC, McKnight B, Meitinger T, Moll FL, Montgomery GW, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Ouwehand WH, Pasterkamp G, Peters A, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ritchie M, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Sebert S, Sever P, Shuldiner AR, Sinisalo J, Steinthorsdottir V, Stolk RP, Tardif JC, Tönjes A, Tremblay A, Tremoli E, Virtamo J, Vohl MC, , , , , Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hayes MG, Hui J, Hunter DJ, Hveem K, Jukema JW, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Powell JE, Power C, Quertermous T, Rauramaa R, Reinmaa E, Ridker PM, Rivadeneira F, Rotter JI, Saaristo TE, Saleheen D, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Strauch K, Stumvoll M, Tuomilehto J, Uusitupa M, van der Harst P, Völzke H, Walker M, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Zanen P, Deloukas P, Heid IM, Lindgren CM, Mohlke KL, Speliotes EK, Thorsteinsdottir U, Barroso I, Fox CS, North KE, Strachan DP, Beckmann JS, Berndt SI, Boehnke M, Borecki IB, McCarthy MI, Metspalu A, Stefansson K, Uitterlinden AG, van Duijn CM, Franke L, Willer CJ, Price AL, Lettre G, Loos RJ, Weedon MN, Ingelsson E, O’Connell JR, Abecasis GR, Chasman DI, Goddard ME, Visscher PM, Hirschhorn JN, Frayling TM. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat. Genet [print-electronic]. 2014 Nov; 46(11): 1173-86. PMID: 25282103, PMCID: PMC4250049, PII: ng.3097, DOI: 10.1038/ng.3097, ISSN: 1546-1718.
-
Dooley KE, Luetkemeyer AF, Park JG, Allen R, Cramer Y, Murray S, Sutherland D, Aweeka F, Koletar SL, Marzan F, Bao J, Savic R, Haas DW, . Phase I safety, pharmacokinetics, and pharmacogenetics study of the antituberculosis drug PA-824 with concomitant lopinavir-ritonavir, efavirenz, or rifampin. Antimicrob. Agents Chemother [print-electronic]. 2014 Sep; 58(9): 5245-52. PMID: 24957823, PMCID: PMC4135849, PII: AAC.03332-14, DOI: 10.1128/AAC.03332-14, ISSN: 1098-6596.
-
Haas DW, Kwara A, Richardson DM, Baker P, Papageorgiou I, Acosta EP, Morse GD, Court MH. Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes. J. Antimicrob. Chemother [print-electronic]. 2014 Aug; 69(8): 2175-82. PMID: 24729586, PMCID: PMC4100708, PII: dku110, DOI: 10.1093/jac/dku110, ISSN: 1460-2091.
-
Haas DW, Severe P, Jean Juste MA, Pape JW, Fitzgerald DW. Functional CYP2B6 variants and virologic response to an efavirenz-containing regimen in Port-au-Prince, Haiti. J. Antimicrob. Chemother [print-electronic]. 2014 Aug; 69(8): 2187-90. PMID: 24695352, PMCID: PMC4100704, PII: dku088, DOI: 10.1093/jac/dku088, ISSN: 1460-2091.
-
Jacobson JM, Wang H, Bordi R, Zheng L, Gross BH, Landay AL, Spritzler J, Routy JP, Benson C, Aberg J, Tebas P, Haas DW, Tiu J, Coughlin K, Purdue L, Sekaly RP, . A randomized controlled trial of palifermin (recombinant human keratinocyte growth factor) for the treatment of inadequate CD4+ T-lymphocyte recovery in patients with HIV-1 infection on antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 2014 Aug 8/1/2014; 66(4): 399-406. PMID: 24815851, PMCID: PMC4216663, DOI: 10.1097/QAI.0000000000000195, ISSN: 1944-7884.
-
Leger PD, Johnson DH, Robbins GK, Shafer RW, Clifford DB, Li J, McLaren PJ, Haas DW. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. J. Neurovirol [print-electronic]. 2014 Jun; 20(3): 304-8. PMID: 24554482, PMCID: PMC4114519, DOI: 10.1007/s13365-014-0235-9, ISSN: 1538-2443.
-
Martin MA, Hoffman JM, Freimuth RR, Klein TE, Dong BJ, Pirmohamed M, Hicks JK, Wilkinson MR, Haas DW, Kroetz DL, . Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update. Clin. Pharmacol. Ther [print-electronic]. 2014 May; 95(5): 499-500. PMID: 24561393, PMCID: PMC3994233, PII: clpt201438, DOI: 10.1038/clpt.2014.38.
-
Johnson DH, Venuto C, Ritchie MD, Morse GD, Daar ES, McLaren PJ, Haas DW. Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202. Pharmacogenet. Genomics. 2014 Apr; 24(4): 195-203. PMID: 24557078, PMCID: PMC4059003, DOI: 10.1097/FPC.0000000000000034, ISSN: 1744-6880.
-
Crist MB, Melekhin VV, Bian A, Shintani A, Milne GL, Kallianpur AR, Dageforde LA, Haas DW, Hulgan T. Higher serum iron is associated with increased oxidant stress in HIV-infected men. J. Acquir. Immune Defic. Syndr. 2013 Dec 12/1/2013; 64(4): 367-73. PMID: 24169121, PMCID: PMC3816092, PII: 00126334-201312010-00007, DOI: 10.1097/QAI.0b013e3182a60f36, ISSN: 1944-7884.
-
Amorosa VK, Luetkemeyer A, Kang M, Johnson VA, Umbleja T, Haas DW, Yesmin S, Bardin MC, Chung RT, Alston-Smith B, Tebas P, Peters MG. Addition of nitazoxanide to PEG-IFN and ribavirin to improve HCV treatment response in HIV-1 and HCV genotype 1 coinfected persons naïve to HCV therapy: results of the ACTG A5269 trial. HIV Clin Trials. 2013 Nov; 14(6): 274-83. PMID: 24334180, PMCID: PMC4113390, PII: 28W6UNK270037691, DOI: 10.1310/hct1406-274, ISSN: 1528-4336.
-
Hulgan T, Stein JH, Cotter BR, Murdock DG, Ritchie MD, Dube MP, Gerschenson M, Haas DW, Torriani FJ, . Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. AIDS Res. Hum. Retroviruses [print-electronic]. 2013 Oct; 29(10): 1293-9. PMID: 23944767, PMCID: PMC3785797, DOI: 10.1089/aid.2013.0079, ISSN: 1931-8405.
-
Johnson DH, Gebretsadik T, Shintani A, Mayo G, Acosta EP, Stein CM, Haas DW. Neuropsychometric correlates of efavirenz pharmacokinetics and pharmacogenetics following a single oral dose. Br J Clin Pharmacol. 2013 Apr; 75(4): 997-1006. PMID: 22957905, PMCID: PMC3612718, DOI: 10.1111/j.1365-2125.2012.04454.x, ISSN: 1365-2125.
-
Johnson DH, Sutherland D, Acosta EP, Erdem H, Richardson D, Haas DW. Genetic and non-genetic determinants of raltegravir penetration into cerebrospinal fluid: a single arm pharmacokinetic study. PLoS ONE. 2013; 8(12): e82672. PMID: 24349334, PMCID: PMC3859605, PII: PONE-D-13-11205, DOI: 10.1371/journal.pone.0082672, ISSN: 1932-6203.
-
Holzinger ER, Grady B, Ritchie MD, Ribaudo HJ, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford DB, Daar ES, McLaren P, Haas DW. Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants. Pharmacogenet. Genomics. 2012 Dec; 22(12): 858-67. PMID: 23080225, PMCID: PMC3614365, DOI: 10.1097/FPC.0b013e32835a450b, ISSN: 1744-6880.
-
Holzinger ER, Hulgan T, Ellis RJ, Samuels DC, Ritchie MD, Haas DW, Kallianpur AR, Bloss CS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Franklin DR, Rosario D, Selph D, Letendre S, Grant I, . Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. J. Neurovirol [print-electronic]. 2012 Dec; 18(6): 511-20. PMID: 23073667, PMCID: PMC3587171, DOI: 10.1007/s13365-012-0133-y, ISSN: 1538-2443.
-
McLaren PJ, Ripke S, Pelak K, Weintrob AC, Patsopoulos NA, Jia X, Erlich RL, Lennon NJ, Kadie CM, Heckerman D, Gupta N, Haas DW, Deeks SG, Pereyra F, Walker BD, de Bakker PI, . Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans. Hum. Mol. Genet [print-electronic]. 2012 Oct 10/1/2012; 21(19): 4334-47. PMID: 22718199, PMCID: PMC3441117, PII: dds226, DOI: 10.1093/hmg/dds226, ISSN: 1460-2083.
-
Haas DW, Mootsikapun P, Ruxrungtham K, Podzamczer D, . Clinical perspectives on human genetic screening to prevent nevirapine toxicity. Per Med. 2012 Sep 9/1/2012; 9(7): 773-82. PMID: 23439719, PMCID: PMC3579661, DOI: 10.2217/pme.12.82, ISSN: 1741-0541.
-
Boger MS, Hulgan T, Haas DW, Mitchell V, Smith AG, Singleton JR, Peltier AC. Measures of small-fiber neuropathy in HIV infection. Auton Neurosci [print-electronic]. 2012 Jul 7/2/2012; 169(1): 56-61. PMID: 22542355, PMCID: PMC3372978, PII: S1566-0702(12)00067-7, DOI: 10.1016/j.autneu.2012.04.001, ISSN: 1872-7484.
-
Pasaniuc B, Rohland N, McLaren PJ, Garimella K, Zaitlen N, Li H, Gupta N, Neale BM, Daly MJ, Sklar P, Sullivan PF, Bergen S, Moran JL, Hultman CM, Lichtenstein P, Magnusson P, Purcell SM, Haas DW, Liang L, Sunyaev S, Patterson N, de Bakker PI, Reich D, Price AL. Extremely low-coverage sequencing and imputation increases power for genome-wide association studies. Nat. Genet. 2012 Jun; 44(6): 631-5. PMID: 22610117, PMCID: PMC3400344, PII: ng.2283, DOI: 10.1038/ng.2283, ISSN: 1546-1718.
-
Dooley KE, Park JG, Swindells S, Allen R, Haas DW, Cramer Y, Aweeka F, Wiggins I, Gupta A, Lizak P, Qasba S, van Heeswijk R, Flexner C, . Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267. J. Acquir. Immune Defic. Syndr. 2012 Apr 4/15/2012; 59(5): 455-62. PMID: 22126739, PMCID: PMC3302922, DOI: 10.1097/QAI.0b013e3182410503, ISSN: 1944-7884.
-
Martin MA, Klein TE, Dong BJ, Pirmohamed M, Haas DW, Kroetz DL, . Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing. Clin. Pharmacol. Ther [print-electronic]. 2012 Apr; 91(4): 734-8. PMID: 22378157, PMCID: PMC3374459, PII: clpt2011355, DOI: 10.1038/clpt.2011.355.
-
Clifford DB, Simpson DM, Brown S, Moyle G, Brew BJ, Conway B, Tobias JK, Vanhove GF, . A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy. J. Acquir. Immune Defic. Syndr. 2012 Feb 2/1/2012; 59(2): 126-33. PMID: 22067661, DOI: 10.1097/QAI.0b013e31823e31f7, ISSN: 1944-7884.
-
Birdwell KA, Grady B, Choi L, Xu H, Bian A, Denny JC, Jiang M, Vranic G, Basford M, Cowan JD, Richardson DM, Robinson MP, Ikizler TA, Ritchie MD, Stein CM, Haas DW. The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet. Genomics. 2012 Jan; 22(1): 32-42. PMID: 22108237, PMCID: PMC3237759, DOI: 10.1097/FPC.0b013e32834e1641, ISSN: 1744-6880.
-
Boger MS, Bian A, Shintani A, Milne GL, Morrow JD, Erdem H, Mitchell V, Haas DW, Hulgan T. Sex differences in urinary biomarkers of vascular and endothelial function in HIV-infected persons receiving antiretroviral therapy. Antivir. Ther. (Lond.) [print-electronic]. 2012; 17(3): 485-93. PMID: 22293574, PMCID: PMC3766979, DOI: 10.3851/IMP1990, ISSN: 2040-2058.
-
Hulgan T, Robbins GK, Kalams SA, Samuels DC, Grady B, Shafer R, Murdock DG, Selph D, Haas DW, Pollard RB, . T cell activation markers and African mitochondrial DNA haplogroups among non-Hispanic black participants in AIDS clinical trials group study 384. PLoS ONE [print-electronic]. 2012; 7(8): e43803. PMID: 22970105, PMCID: PMC3433792, PII: PONE-D-12-11386, DOI: 10.1371/journal.pone.0043803, ISSN: 1932-6203.
-
Grady BJ, Samuels DC, Robbins GK, Selph D, Canter JA, Pollard RB, Haas DW, Shafer R, Kalams SA, Murdock DG, Ritchie MD, Hulgan T, . Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384. J. Acquir. Immune Defic. Syndr. 2011 Dec 12/1/2011; 58(4): 363-70. PMID: 21792066, PMCID: PMC3204178, DOI: 10.1097/QAI.0b013e31822c688b, ISSN: 1944-7884.
-
Haas DW, Kuritzkes DR, Ritchie MD, Amur S, Gage BF, Maartens G, Masys D, Fellay J, Phillips E, Ribaudo HJ, Freedberg KA, Petropoulos C, Manolio TA, Gulick RM, Haubrich R, Kim P, Dehlinger M, Abebe R, Telenti A, . Pharmacogenomics of HIV therapy: summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases. HIV Clin Trials. 2011 Sep; 12(5): 277-85. PMID: 22180526, PMCID: PMC3322423, PII: H4HV83200516XH08, DOI: 10.1310/hct1205-277, ISSN: 1528-4336.
-
Almeida CA, Bronke C, Roberts SG, McKinnon E, Keane NM, Chopra A, Kadie C, Carlson J, Haas DW, Riddler SA, Haubrich R, Heckerman D, Mallal S, John M. Translation of HLA-HIV associations to the cellular level: HIV adapts to inflate CD8 T cell responses against Nef and HLA-adapted variant epitopes. J. Immunol [print-electronic]. 2011 Sep 9/1/2011; 187(5): 2502-13. PMID: 21821798, PMCID: PMC3183574, PII: jimmunol.1100691, DOI: 10.4049/jimmunol.1100691, ISSN: 1550-6606.
-
Yuan J, Guo S, Hall D, Cammett AM, Jayadev S, Distel M, Storfer S, Huang Z, Mootsikapun P, Ruxrungtham K, Podzamczer D, Haas DW, . Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent. AIDS. 2011 Jun 6/19/2011; 25(10): 1271-80. PMID: 21505298, PMCID: PMC3387531, DOI: 10.1097/QAD.0b013e32834779df, ISSN: 1473-5571.
-
Hulgan T, Haubrich R, Riddler SA, Tebas P, Ritchie MD, McComsey GA, Haas DW, Canter JA. European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142. AIDS. 2011 Jan 1/2/2011; 25(1): 37-47. PMID: 20871389, PMCID: PMC2995830, DOI: 10.1097/QAD.0b013e32833f9d02, ISSN: 1473-5571.
-
Grady BJ, Torstenson ES, McLaren PJ, DE Bakker PI, Haas DW, Robbins GK, Gulick RM, Haubrich R, Ribaudo H, Ritchie MD. Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pac Symp Biocomput. 2011; 253-64. PMID: 21121053, PMCID: PMC3094912, PII: 9789814335058_0027, ISSN: 2335-6936.
-
Currier J, Averitt Bridge D, Hagins D, Zorrilla CD, Feinberg J, Ryan R, Falcon R, Tennenberg A, Mrus J, Squires K, . Sex-based outcomes of darunavir-ritonavir therapy: a single-group trial. Ann. Intern. Med. 2010 Sep 9/21/2010; 153(6): 349-57. PMID: 20855799, PMCID: PMC3056066, PII: 153/6/349, DOI: 10.7326/0003-4819-153-6-201009210-00002, ISSN: 1539-3704.
-
Ribaudo HJ, Liu H, Schwab M, Schaeffeler E, Eichelbaum M, Motsinger-Reif AA, Ritchie MD, Zanger UM, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford D, Haas DW. Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. J. Infect. Dis. 2010 Sep 9/1/2010; 202(5): 717-22. PMID: 20662624, PMCID: PMC2919241, DOI: 10.1086/655470, ISSN: 1537-6613.
-
Canter JA, Robbins GK, Selph D, Clifford DB, Kallianpur AR, Shafer R, Levy S, Murdock DG, Ritchie MD, Haas DW, Hulgan T, , . African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy. J. Infect. Dis. 2010 Jun 6/1/2010; 201(11): 1703-7. PMID: 20402593, PMCID: PMC2862090, DOI: 10.1086/652419, ISSN: 1537-6613.
-
John M, Heckerman D, James I, Park LP, Carlson JM, Chopra A, Gaudieri S, Nolan D, Haas DW, Riddler SA, Haubrich R, Mallal S. Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. J. Immunol [print-electronic]. 2010 Apr 4/15/2010; 184(8): 4368-77. PMID: 20231689, PMCID: PMC3011274, PII: jimmunol.0903745, DOI: 10.4049/jimmunol.0903745, ISSN: 1550-6606.
-
Smith JP, Weller S, Johnson B, Nicotera J, Luther JM, Haas DW. Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function. Antimicrob. Agents Chemother [print-electronic]. 2010 Mar; 54(3): 1146-51. PMID: 20038622, PMCID: PMC2825963, PII: AAC.00729-09, DOI: 10.1128/AAC.00729-09, ISSN: 1098-6596.
-
Sadagopal S, Lorey SL, Barnett L, Sutherland D, Basham R, Erdem H, Kalams SA, Haas DW. Enhanced PD-1 expression by T cells in cerebrospinal fluid does not reflect functional exhaustion during chronic human immunodeficiency virus type 1 infection. J. Virol [print-electronic]. 2010 Jan; 84(1): 131-40. PMID: 19828602, PMCID: PMC2798447, PII: JVI.01181-09, DOI: 10.1128/JVI.01181-09, ISSN: 1098-5514.
-
Xu H, Doan S, Birdwell KA, Cowan JD, Vincz AJ, Haas DW, Basford MA, Denny JC. An automated approach to calculating the daily dose of tacrolimus in electronic health records. AMIA Jt Summits Transl Sci Proc. 2010; 2010: 71-5. PMID: 21347153, PMCID: PMC3041548, ISSN: 2153-4063.
-
Boger MS, Shintani A, Redhage LA, Mitchell V, Haas DW, Morrow JD, Hulgan T. Highly sensitive C-reactive protein, body mass index, and serum lipids in HIV-infected persons receiving antiretroviral therapy: a longitudinal study. J. Acquir. Immune Defic. Syndr. 2009 Dec 12/1/2009; 52(4): 480-7. PMID: 19911471, PMCID: PMC2794651, ISSN: 1944-7884.
-
Hulgan T, Donahue JP, Smeaton L, Pu M, Wang H, Lederman MM, Smith K, Valdez H, Pilcher C, Haas DW, . Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors. Eur. J. Clin. Pharmacol. 2009 Nov; 65(11): 1081-8. PMID: 19779705, PMCID: PMC2873632, DOI: 10.1007/s00228-009-0725-5, ISSN: 1432-1041.
-
Basham RJ, Richardson DM, Sutcliffe CB, Haas DW. Effect of HIV-1 infection on human DNA yield from saliva. HIV Clin Trials. 2009 Jul; 10(4): 282-5. PMID: 19723616, PMCID: PMC2761620, PII: Y65W64K36346NK41, DOI: 10.1310/hct1004-282, ISSN: 1528-4336.
-
Redhage LA, Shintani A, Haas DW, Emeagwali N, Markovic M, Oboho I, Mwenya C, Erdem H, Acosta EP, Morrow JD, Hulgan T. Clinical factors associated with plasma F2-isoprostane levels in HIV-infected adults. HIV Clin Trials. 2009 May; 10(3): 181-92. PMID: 19632957, PMCID: PMC2891063, PII: BG421Q1XL1393227, DOI: 10.1310/hct1003-181, ISSN: 1528-4336.
-
Haas DW, Gebretsadik T, Mayo G, Menon UN, Acosta EP, Shintani A, Floyd M, Stein CM, Wilkinson GR. Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans. J. Infect. Dis. 2009 Mar 3/15/2009; 199(6): 872-80. PMID: 19239339, PMCID: PMC2784690, DOI: 10.1086/597125, ISSN: 0022-1899.
-
Haas DW, Koletar SL, Laughlin L, Kendall MA, Suckow C, Gerber JG, Zolopa AR, Bertz R, Child MJ, Hosey L, Alston-Smith B, Acosta EP, . Hepatotoxicity and gastrointestinal intolerance when healthy volunteers taking rifampin add twice-daily atazanavir and ritonavir. J. Acquir. Immune Defic. Syndr. 2009 Mar 3/1/2009; 50(3): 290-3. PMID: 19194314, PMCID: PMC2653210, DOI: 10.1097/QAI.0b013e318189a7df, ISSN: 1525-4135.
-
Sadagopal S, Lorey SL, Barnett L, Basham R, Lebo L, Erdem H, Haman K, Avison M, Waddell K, Haas DW, Kalams SA. Enhancement of human immunodeficiency virus (HIV)-specific CD8+ T cells in cerebrospinal fluid compared to those in blood among antiretroviral therapy-naive HIV-positive subjects. J. Virol [print-electronic]. 2008 Nov; 82(21): 10418-28. PMID: 18715919, PMCID: PMC2573184, PII: JVI.01190-08, DOI: 10.1128/JVI.01190-08, ISSN: 1098-5514.
-
Pepper T, Joseph P, Mwenya C, McKee GS, Haushalter A, Carter A, Warkentin J, Haas DW, Sterling TR. Normal chest radiography in pulmonary tuberculosis: implications for obtaining respiratory specimen cultures. Int. J. Tuberc. Lung Dis. 2008 Apr; 12(4): 397-403. PMID: 18371265, ISSN: 1027-3719.
-
Hulgan T, Tebas P, Canter JA, Mulligan K, Haas DW, Dubé M, Grinspoon S, Robbins GK, Motsinger AA, Kallianpur AR, . Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy. J. Infect. Dis. 2008 Mar 3/15/2008; 197(6): 858-66. PMID: 18419350, DOI: 10.1086/528697, ISSN: 0022-1899.
-
Canter JA, Haas DW, Kallianpur AR, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Murdock DG, Hulgan T. The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenomics J [print-electronic]. 2008 Feb; 8(1): 71-7. PMID: 17684475, PII: 6500470, DOI: 10.1038/sj.tpj.6500470, ISSN: 1470-269X.
-
Motsinger AA, Haas DW, Hulgan T, Ritchie MD. Human genomic association studies: a primer for the infectious diseases specialist. J. Infect. Dis [print-electronic]. 2007 Jun 6/15/2007; 195(12): 1737-44. PMID: 17492588, PII: JID37481, DOI: 10.1086/518247, ISSN: 0022-1899.
-
Oswald-Richter K, Grill SM, Leelawong M, Tseng M, Kalams SA, Hulgan T, Haas DW, Unutmaz D. Identification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection. PLoS Pathog. 2007 Apr; 3(4): e58. PMID: 17465678, PMCID: PMC1857714, PII: 06-PLPA-RA-0420R2, DOI: 10.1371/journal.ppat.0030058, ISSN: 1553-7374.
-
Motsinger AA, Ritchie MD, Shafer RW, Robbins GK, Morse GD, Labbe L, Wilkinson GR, Clifford DB, D’Aquila RT, Johnson VA, Pollard RB, Merigan TC, Hirsch MS, Donahue JP, Kim RB, Haas DW. Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study. Pharmacogenet. Genomics. 2006 Nov; 16(11): 837-45. PMID: 17047492, PII: 01213011-200611000-00009, DOI: 10.1097/01.fpc.0000230413.97596.fa, ISSN: 1744-6872.
-
Haas DW, Geraghty DE, Andersen J, Mar J, Motsinger AA, D’Aquila RT, Unutmaz D, Benson CA, Ritchie MD, Landay A, . Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study. J. Infect. Dis [print-electronic]. 2006 Oct 10/15/2006; 194(8): 1098-107. PMID: 16991084, PII: JID36554, DOI: 10.1086/507313, ISSN: 0022-1899.
-
Haas DW, Bartlett JA, Andersen JW, Sanne I, Wilkinson GR, Hinkle J, Rousseau F, Ingram CD, Shaw A, Lederman MM, Kim RB, . Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. Clin. Infect. Dis [print-electronic]. 2006 Sep 9/15/2006; 43(6): 783-6. PMID: 16912957, PII: CID39497, DOI: 10.1086/507097, ISSN: 1537-6591.
-
Ritchie MD, Haas DW, Motsinger AA, Donahue JP, Erdem H, Raffanti S, Rebeiro P, George AL, Kim RB, Haines JL, Sterling TR. Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Clin. Infect. Dis [print-electronic]. 2006 Sep 9/15/2006; 43(6): 779-82. PMID: 16912956, PII: CID39498, DOI: 10.1086/507101, ISSN: 1537-6591.
-
Hulgan T, Hughes M, Sun X, Smeaton LM, Terry E, Robbins GK, Shafer RW, Clifford DB, McComsey GA, Canter JA, Morrow JD, Haas DW. Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study. J. Acquir. Immune Defic. Syndr. 2006 Aug 8/1/2006; 42(4): 450-4. PMID: 16791116, DOI: 10.1097/01.qai.0000226792.16216.1c, ISSN: 1525-4135.
-
Hulgan T, Hughes M, Sun X, Smeaton LM, Terry E, Robbins GK, Shafer RW, Clifford DB, McComsey GA, Canter JA, Morrow JD, Haas DW. Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study. J. Acquir. Immune Defic. Syndr. 2006 Aug 8/1/2006; 42(4): 450-4. PMID: 16791116, DOI: 10.1097/01.qai.0000226792.16216.1c, ISSN: 1525-4135.
-
Kallianpur AR, Hulgan T, Canter JA, Ritchie MD, Haines JL, Robbins GK, Shafer RW, Clifford DB, Haas DW. Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy. AIDS. 2006 Jul 7/13/2006; 20(11): 1503-13. PMID: 16847405, PII: 00002030-200607130-00005, DOI: 10.1097/01.aids.0000237366.56864.3c, ISSN: 0269-9370.
-
Sterling TR, Haas DW. Transmission of Mycobacterium tuberculosis from health care workers. N. Engl. J. Med. 2006 Jul 7/13/2006; 355(2): 118-21. PMID: 16837674, PII: 355/2/118, DOI: 10.1056/NEJMp068015, ISSN: 1533-4406.
-
Haas DW. Human genetic variability and HIV treatment response. Curr HIV/AIDS Rep. 2006 Jul; 3(2): 53-8. PMID: 16608660, ISSN: 1548-3568.
-
Haas DW. Can responses to antiretroviral therapy be improved by therapeutic drug monitoring?. Clin. Infect. Dis [print-electronic]. 2006 Apr 4/15/2006; 42(8): 1197-9. PMID: 16575742, PII: CID38976, DOI: 10.1086/501464, ISSN: 1537-6591.
-
Haas DW, Smeaton LM, Shafer RW, Robbins GK, Morse GD, Labbe L, Wilkinson GR, Clifford DB, D’Aquila RT, De Gruttola V, Pollard RB, Merigan TC, Hirsch MS, George AL, Donahue JP, Kim RB. Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study. J. Infect. Dis [print-electronic]. 2005 Dec 12/1/2005; 192(11): 1931-42. PMID: 16267764, PII: JID34852, DOI: 10.1086/497610, ISSN: 0022-1899.
-
Hulgan T, Haas DW, Haines JL, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Kallianpur AR, Summar M, Canter JA. Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS. 2005 Sep 9/2/2005; 19(13): 1341-9. PMID: 16103764, PII: 00002030-200509020-00001, ISSN: 0269-9370.
-
Haas DW. Will pharmacogenomic discoveries improve HIV therapeutics?. Top HIV Med. 2005 Aug; 13(3): 90-5. PMID: 16170225, ISSN: 1542-8826.
-
Haas DW, Ribaudo HJ, Kim RB, Tierney C, Wilkinson GR, Gulick RM, Clifford DB, Hulgan T, Marzolini C, Acosta EP. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS. 2004 Dec 12/3/2004; 18(18): 2391-400. PMID: 15622315, PII: 00002030-200412030-00006, ISSN: 0269-9370.
-
Oswald-Richter K, Grill SM, Shariat N, Leelawong M, Sundrud MS, Haas DW, Unutmaz D. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol [print-electronic]. 2004 Jul; 2(7): E198. PMID: 15252446, PMCID: PMC449855, DOI: 10.1371/journal.pbio.0020198, ISSN: 1545-7885.
-
Haas DW. Sequence heterogeneity and viral dynamics in cerebrospinal fluid and plasma during antiretroviral therapy. J. Neurovirol. 2004; 10 Suppl 1: 33-7. PMID: 14982737, PII: JQYP5UVQ9GRAP0FN, ISSN: 1355-0284.
-
Hulgan T, Morrow J, D’Aquila RT, Raffanti S, Morgan M, Rebeiro P, Haas DW. Oxidant stress is increased during treatment of human immunodeficiency virus infection. Clin. Infect. Dis [print-electronic]. 2003 Dec 12/15/2003; 37(12): 1711-7. PMID: 14689356, PII: CID31711, DOI: 10.1086/379776, ISSN: 1537-6591.
-
Haas DW, Johnson BW, Spearman P, Raffanti S, Nicotera J, Schmidt D, Hulgan T, Shepard R, Fiscus SA. Two phases of HIV RNA decay in CSF during initial days of multidrug therapy. Neurology. 2003 Nov 11/25/2003; 61(10): 1391-6. PMID: 14638961, ISSN: 1526-632X.
-
Haas DW, Wu H, Li H, Bosch RJ, Lederman MM, Kuritzkes D, Landay A, Connick E, Benson C, Wilkinson GR, Kessler H, Kim RB. MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. J. Acquir. Immune Defic. Syndr. 2003 Nov 11/1/2003; 34(3): 295-8. PMID: 14600574, ISSN: 1525-4135.
-
Hulgan T, Donahue JP, Hawkins C, Unutmaz D, D’Aquila RT, Raffanti S, Nicotera F, Rebeiro P, Erdem H, Rueff M, Haas DW. Implications of T-cell P-glycoprotein activity during HIV-1 infection and its therapy. J. Acquir. Immune Defic. Syndr. 2003 Oct 10/1/2003; 34(2): 119-26. PMID: 14526200, ISSN: 1525-4135.
-
Haas DW, Wilkinson GR, Kuritzkes DR, Richman DD, Nicotera J, Mahon LF, Sutcliffe C, Siminski S, Andersen J, Coughlin K, Clayton EW, Haines J, Marshak A, Saag M, Lawrence J, Gustavson J, Anne Bennett J, Christensen R, Matula MA, Wood AJ, . A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG Protocol A5128. HIV Clin Trials. 2003 Sep; 4(5): 287-300. PMID: 14583845, DOI: 10.1310/MUQC-QXBC-8118-BPM5, ISSN: 1528-4336.
-
Haas DW, Johnson B, Nicotera J, Bailey VL, Harris VL, Bowles FB, Raffanti S, Schranz J, Finn TS, Saah AJ, Stone J. Effects of ritonavir on indinavir pharmacokinetics in cerebrospinal fluid and plasma. Antimicrob. Agents Chemother. 2003 Jul; 47(7): 2131-7. PMID: 12821458, PMCID: PMC161873, ISSN: 0066-4804.
-
Lu HZ, Weng XH, Zhu B, Li H, Yin YK, Zhang YX, Haas DW, Tang YW. Major outbreak of toxic shock-like syndrome caused by Streptococcus mitis. J. Clin. Microbiol. 2003 Jul; 41(7): 3051-5. PMID: 12843042, PMCID: PMC165286, ISSN: 0095-1137.
-
Haas DW, Zala C, Schrader S, Piliero P, Jaeger H, Nunes D, Thiry A, Schnittman S, Sension M, . Therapy with atazanavir plus saquinavir in patients failing highly active antiretroviral therapy: a randomized comparative pilot trial. AIDS. 2003 Jun 6/13/2003; 17(9): 1339-49. PMID: 12799555, DOI: 10.1097/01.aids.0000060389.18106.0a, ISSN: 0269-9370.
-
Donahue JP, Dowdy D, Ratnam KK, Hulgan T, Price J, Unutmaz D, Nicotera J, Raffanti S, Becker M, Haas DW. Effects of nelfinavir and its M8 metabolite on lymphocyte P-glycoprotein activity during antiretroviral therapy. Clin. Pharmacol. Ther. 2003 Jan; 73(1): 78-86. PMID: 12545146, PII: S0009923602176120, DOI: 10.1067/mcp.2003.11, ISSN: 0009-9236.
-
Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J. Exp. Med. 2002 Apr 4/1/2002; 195(7): 869-79. PMID: 11927631, PMCID: PMC2193731, ISSN: 0022-1007.
-
Tang YW, Li H, Griffin JP, Haas DW, D’Agata EM. Rapidly increasing prevalence of penicillin-resistant Streptococcus pneumoniae in middle Tennessee: a 10-year clinical and molecular analysis. J. Clin. Microbiol. 2002 Feb; 40(2): 395-9. PMID: 11825948, PMCID: PMC153403, ISSN: 0095-1137.
-
Spearman P, Fiscus SA, Smith RM, Shepard R, Johnson B, Nicotera J, Harris VL, Clough LA, McKinsey J, Haas DW. Comparison of Roche MONITOR and Organon Teknika NucliSens assays to quantify human immunodeficiency virus type 1 RNA in cerebrospinal fluid. J. Clin. Microbiol. 2001 Apr; 39(4): 1612-4. PMID: 11283098, PMCID: PMC87981, DOI: 10.1128/JCM.39.4.1612-1614.2001, ISSN: 0095-1137.
-
Haas DW, Fessel WJ, Delapenha RA, Kessler H, Seekins D, Kaplan M, Ruiz NM, Ploughman LM, Labriola DF, Manion DJ. Therapy with efavirenz plus indinavir in patients with extensive prior nucleoside reverse-transcriptase inhibitor experience: a randomized, double-blind, placebo-controlled trial. J. Infect. Dis [print-electronic]. 2001 Feb 2/1/2001; 183(3): 392-400. PMID: 11133370, PII: JID000946, DOI: 10.1086/318083, ISSN: 0022-1899.
-
Tang YW, Huong JT, Lloyd RM, Spearman P, Haas DW. Comparison of human immunodeficiency virus type 1 RNA sequence heterogeneity in cerebrospinal fluid and plasma. J. Clin. Microbiol. 2000 Dec; 38(12): 4637-9. PMID: 11101610, PMCID: PMC87651, ISSN: 0095-1137.
-
Weitkamp JH, Tang YW, Haas DW, Midha NK, Crowe JE. Recurrent Achromobacter xylosoxidans bacteremia associated with persistent lymph node infection in a patient with hyper-immunoglobulin M syndrome. Clin. Infect. Dis [print-electronic]. 2000 Nov; 31(5): 1183-7. PMID: 11073750, PII: CID994327, DOI: 10.1086/317461, ISSN: 1058-4838.
-
Haas DW, Clough LA, Johnson BW, Harris VL, Spearman P, Wilkinson GR, Fletcher CV, Fiscus S, Raffanti S, Donlon R, McKinsey J, Nicotera J, Schmidt D, Shoup RE, Kates RE, Lloyd RM, Larder B. Evidence of a source of HIV type 1 within the central nervous system by ultraintensive sampling of cerebrospinal fluid and plasma. AIDS Res. Hum. Retroviruses. 2000 Oct 10/10/2000; 16(15): 1491-502. PMID: 11054262, DOI: 10.1089/088922200750006010, ISSN: 0889-2229.
-
Haas DW, Stone J, Clough LA, Johnson B, Spearman P, Harris VL, Nicotera J, Johnson RH, Raffanti S, Zhong L, Bergqwist P, Chamberlin S, Hoagland V, Ju WD. Steady-state pharmacokinetics of indinavir in cerebrospinal fluid and plasma among adults with human immunodeficiency virus type 1 infection. Clin. Pharmacol. Ther. 2000 Oct; 68(4): 367-74. PMID: 11061576, PII: S0009-9236(00)09021-4, DOI: 10.1067/mcp.2000.109391, ISSN: 0009-9236.
-
Haas DW, Arathoon E, Thompson MA, de Jesus Pedro R, Gallant JE, Uip DE, Currier J, Noriega LM, Lewi DS, Uribe P, Benetucci L, Cahn P, Paar D, White AC, Collier AC, Ramirez-Ronda CH, Harvey C, Chung MO, Mehrotra D, Chodakewitz J, Nguyen BY, . Comparative studies of two-times-daily versus three-times-daily indinavir in combination with zidovudine and lamivudine. AIDS. 2000 Sep 9/8/2000; 14(13): 1973-8. PMID: 10997402, ISSN: 0269-9370.
-
Luther JM, Lakey DL, Larson RS, Kallianpur AR, D’Agata E, Cousar JB, Haas DW. Utility of bone marrow biopsy for rapid diagnosis of febrile illnesses in patients with human immunodeficiency virus infection. South. Med. J. 2000 Jul; 93(7): 692-7. PMID: 10923958, ISSN: 0038-4348.
-
Slovis BS, Plitman JD, Haas DW. The case against anergy testing as a routine adjunct to tuberculin skin testing. JAMA. 2000 Apr 4/19/2000; 283(15): 2003-7. PMID: 10789669, PII: jsc90281, ISSN: 0098-7484.
-
Teller RE, Christie MJ, Martin W, Nance EP, Haas DW. Sequential indium-labeled leukocyte and bone scans to diagnose prosthetic joint infection. Clin. Orthop. Relat. Res. 2000 Apr; (373): 241-7. PMID: 10810483, ISSN: 0009-921X.
-
Wright SW, Wrenn KD, Haynes M, Haas DW. Prevalence and risk factors for multidrug resistant uropathogens in ED patients. Am J Emerg Med. 2000 Mar; 18(2): 143-6. PMID: 10750917, ISSN: 0735-6757.
-
Haas DW, Lavelle J, Nadler JP, Greenberg SB, Frame P, Mustafa N, St Clair M, McKinnis R, Dix L, Elkins M, Rooney J. A randomized trial of interferon alpha therapy for HIV type 1 infection. AIDS Res. Hum. Retroviruses. 2000 Feb 2/10/2000; 16(3): 183-90. PMID: 10710206, DOI: 10.1089/088922200309278, ISSN: 0889-2229.
-
Green K, Schulman G, Haas DW, Schaffner W, D’Agata EM. Vancomycin prescribing practices in hospitalized chronic hemodialysis patients. Am. J. Kidney Dis. 2000 Jan; 35(1): 64-8. PMID: 10620546, PII: S0272-6386(00)70303-9, DOI: 10.1016/S0272-6386(00)70303-9, ISSN: 1523-6838.
-
Clough LA, D’Agata E, Raffanti S, Haas DW. Factors that predict incomplete virological response to protease inhibitor-based antiretroviral therapy. Clin. Infect. Dis. 1999 Jul; 29(1): 75-81; discussion 82. PMID: 10433568, DOI: 10.1086/520185, ISSN: 1058-4838.
-
Klekamp J, Spengler DM, McNamara MJ, Haas DW. Risk factors associated with methicillin-resistant staphylococcal wound infection after spinal surgery. J Spinal Disord. 1999 Jun; 12(3): 187-91. PMID: 10382770, ISSN: 0895-0385.
-
Klekamp J, Dawson JM, Haas DW, DeBoer D, Christie M. The use of vancomycin and tobramycin in acrylic bone cement: biomechanical effects and elution kinetics for use in joint arthroplasty. J Arthroplasty. 1999 Apr; 14(3): 339-46. PMID: 10220189, PII: S0883-5403(99)90061-X, ISSN: 0883-5403.
-
Klekamp JW, DiPersio D, Haas DW. No influence of large volume blood loss on serum vancomycin concentrations during orthopedic procedures. Acta Orthop Scand. 1999 Feb; 70(1): 47-50. PMID: 10191748, ISSN: 0001-6470.
-
Haas DW, Milton S, Kreiswirth BN, Brinsko VL, Bifani PJ, Schaffner W. Nosocomial transmission of a drug-sensitive W-variant Mycobacterium tuberculosis strain among patients with acquired immunodeficiency syndrome in Tennessee. Infect Control Hosp Epidemiol. 1998 Sep; 19(9): 635-9. PMID: 9778159, ISSN: 0899-823X.
-
Haas DW, Lederman MM, Clough LA, Wallis RS, Chernoff D, Crampton SL. Proinflammatory cytokine and human immunodeficiency virus RNA levels during early Mycobacterium avium complex bacteremia in advanced AIDS. J. Infect. Dis. 1998 Jun; 177(6): 1746-9. PMID: 9607863, ISSN: 0022-1899.
-
Haas DW, McAndrew MP. Bacterial osteomyelitis in adults: evolving considerations in diagnosis and treatment. Am. J. Med. 1996 Nov; 101(5): 550-61. PMID: 8948280, PII: S0002934396002604, ISSN: 0002-9343.
-
Haas DW, Bonczar T. Effect of replacing cefotaxime with ceftizoxime in a hospital where penicillin-resistant pneumococcal disease is prevalent. J. Antimicrob. Chemother. 1996 Aug; 38(2): 293-9. PMID: 8877545, ISSN: 0305-7453.
-
Haas DW, Stratton CW, Griffin JP, Weeks L, Alls SC. Diminished activity of ceftizoxime in comparison to cefotaxime and ceftriaxone against Streptococcus pneumoniae. Clin. Infect. Dis. 1995 Mar; 20(3): 671-6. PMID: 7756494, ISSN: 1058-4838.
-
Antony SJ, Haas DW. Tuberculous pericarditis in an HIV-infected patient. Scand. J. Infect. Dis. 1995; 27(4): 411-3. PMID: 8658082, ISSN: 0036-5548.
-
Neuzil KM, Wang E, Haas DW, Blaser MJ. Persistence of Campylobacter fetus bacteremia associated with absence of opsonizing antibodies. J. Clin. Microbiol. 1994 Jul; 32(7): 1718-20. PMID: 7929763, PMCID: PMC263773, ISSN: 0095-1137.
-
Haas DW, Des Prez RM. Tuberculosis and acquired immunodeficiency syndrome: a historical perspective on recent developments. Am. J. Med. 1994 May; 96(5): 439-50. PMID: 8192176, PII: 0002-9343(94)90171-6, ISSN: 0002-9343.
-
Harley WB, Lomis M, Haas DW. Marked polymorphonuclear pleocytosis due to blastomycotic meningitis: case report and review. Clin. Infect. Dis. 1994 May; 18(5): 816-8. PMID: 8075280, ISSN: 1058-4838.
-
Bu X, Haas DW, Hagedorn CH. Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits. J. Biol. Chem. 1993 Mar 3/5/1993; 268(7): 4975-8. PMID: 8444875, ISSN: 0021-9258.
-
Haas DW, Hagedorn CH. Protein kinase C phosphorylates both serine and threonine residues of the mRNA cap binding protein eIF-4E. Second Messengers Phosphoproteins. 1992; 14(1-2): 55-63. PMID: 1403850, ISSN: 0895-7479.
-
Haas DW, Shepherd VL, Hagedorn CH. Lipopolysaccharide stimulates phosphorylation of eukaryotic initiation factor-4F in macrophages and tumor necrosis factor participates in this event. Second Messengers Phosphoproteins. 1992; 14(3): 163-71. PMID: 1345341, ISSN: 0895-7479.
-
Haas DW, Hagedorn CH. Casein kinase I phosphorylates the 25-kDa mRNA cap-binding protein. Arch. Biochem. Biophys. 1991 Jan; 284(1): 84-9. PMID: 1989504, PII: 0003-9861(91)90267-M, ISSN: 0003-9861.
-
Sneeringer RM, Haas DW. Cutaneous alternaria infection in a patient on chronic corticosteroids. J Tenn Med Assoc. 1990 Jan; 83(1): 15-7. PMID: 2403614, ISSN: 0040-3318.
-
Haas DW, Gregory DW. Fever and abdominal pain in a southeast Asian man. South. Med. J. 1989 Jan; 82(1): 47-50. PMID: 2911762, ISSN: 0038-4348.
-
McMullin EL, Haas DW, Abramson RD, Thach RE, Merrick WC, Hagedorn CH. Identification of a protein kinase activity in rabbit reticulocytes that phosphorylates the mRNA cap binding protein. Biochem. Biophys. Res. Commun. 1988 May 5/31/1988; 153(1): 340-6. PMID: 2967701, PII: S0006-291X(88)81228-2, ISSN: 0006-291X.