Raymond Blind, Ph.D.

Associate Professor of Medicine

: ray.blind@vanderbilt.edu

Nuclear Lipid Signaling

Research Description

Nuclear Lipid Signaling

Selected Publications

Hamann BL, Blind RD. Nuclear phosphoinositide regulation of chromatin. J. Cell. Physiol [print-electronic]. 2018 Jan; 233(1): 107-23. PMID: 28256711, DOI: 10.1002/jcp.25886, ISSN: 1097-4652.
Crowder MK, Seacrist CD, Blind RD. Phospholipid regulation of the nuclear receptor superfamily. Adv Biol Regul [print-electronic]. 2016 Oct 10/29/2016; PMID: 27838257, PII: S2212-4926(16)30046-X, DOI: 10.1016/j.jbior.2016.10.006, ISSN: 2212-4934.
Malabanan MM, Blind RD. Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism. Biochem. Soc. Trans. 2016 Feb; 44(1): 279-85. PMID: 26862216, PII: BST20150225, DOI: 10.1042/BST20150225, ISSN: 1470-8752.
Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J. Struct. Biol [print-electronic]. 2015 Dec; 192(3): 342-8. PMID: 26416531, PMCID: PMC4651778, PII: S1047-8477(15)30067-8, DOI: 10.1016/j.jsb.2015.09.012, ISSN: 1095-8657.
Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Oct 10/21/2014; 111(42): 15054-9. PMID: 25288771, PMCID: PMC4210282, PII: 1416740111, DOI: 10.1073/pnas.1416740111, ISSN: 1091-6490.
Blind RD. Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes. Adv Biol Regul [print-electronic]. 2014 Jan; 54: 25-38. PMID: 24176936, PMCID: PMC3946453, PII: S2212-4926(13)00089-4, DOI: 10.1016/j.jbior.2013.09.015, ISSN: 2212-4934.
Blind RD, Suzawa M, Ingraham HA. Direct modification and activation of a nuclear receptor-PIP2 complex by the inositol lipid kinase IPMK. Sci Signal. 2012 Jun 6/19/2012; 5(229): ra44. PMID: 22715467, PMCID: PMC3395721, PII: 5/229/ra44, DOI: 10.1126/scisignal.2003111, ISSN: 1937-9145.
Blind RD, Pineda-Torra I, Xu Y, Xu HE, Garabedian MJ. Ligand structural motifs can decouple glucocorticoid receptor transcriptional activation from target promoter occupancy. Biochem. Biophys. Res. Commun [print-electronic]. 2012 Apr 4/20/2012; 420(4): 839-44. PMID: 22465009, PMCID: PMC3340612, PII: S0006-291X(12)00544-X, DOI: 10.1016/j.bbrc.2012.03.084, ISSN: 1090-2104.
Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J. Med. Chem [print-electronic]. 2011 Apr 4/14/2011; 54(7): 2266-81. PMID: 21391689, PMCID: PMC4151520, DOI: 10.1021/jm1014296, ISSN: 1520-4804.
Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K. Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metab. 2010 Oct 10/6/2010; 12(4): 398-410. PMID: 20889131, PMCID: PMC2992884, PII: S1550-4131(10)00299-8, DOI: 10.1016/j.cmet.2010.08.013, ISSN: 1932-7420.
Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA. Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res [print-electronic]. 2009 Jul 7/1/2009; 69(13): 5415-23. PMID: 19549922, PMCID: PMC2756996, PII: 0008-5472.CAN-08-1622, DOI: 10.1158/0008-5472.CAN-08-1622, ISSN: 1538-7445.
Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol. Endocrinol [print-electronic]. 2009 Jan; 23(1): 25-34. PMID: 18988706, PMCID: PMC2646595, PII: me.2007-0508, DOI: 10.1210/me.2007-0508, ISSN: 0888-8809.
Omer S, Hickson G, Taché S, Blind R, Masters S, Loeser H, Souza K, Mkony C, Debas H, O’Sullivan P. Applying innovative educational principles when classes grow and resources are limited: Biochemistry experiences at Muhimbili University of Allied Health Sciences. Biochem Mol Biol Educ. 2008 Nov; 36(6): 387-94. PMID: 21591227, DOI: 10.1002/bmb.20210, ISSN: 1470-8175.
Chen W, Dang T, Blind RD, Wang Z, Cavasotto CN, Hittelman AB, Rogatsky I, Logan SK, Garabedian MJ. Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol. Endocrinol [print-electronic]. 2008 Aug; 22(8): 1754-66. PMID: 18483179, PMCID: PMC2725771, PII: me.2007-0219, DOI: 10.1210/me.2007-0219, ISSN: 0888-8809.
Blind RD, Garabedian MJ. Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes. J. Steroid Biochem. Mol. Biol [print-electronic]. 2008 Mar; 109(1-2): 150-7. PMID: 18304804, PMCID: PMC2699583, PII: S0960-0760(08)00021-6, DOI: 10.1016/j.jsbmb.2008.01.002, ISSN: 0960-0760.
Ismaili N, Blind R, Garabedian MJ. Stabilization of the unliganded glucocorticoid receptor by TSG101. J. Biol. Chem [print-electronic]. 2005 Mar 3/25/2005; 280(12): 11120-6. PMID: 15657031, PII: M500059200, DOI: 10.1074/jbc.M500059200, ISSN: 0021-9258.