Job Opportunity: Senior Scientist, BRD Pilot Plant, Pfizer, St. Louis, MO
https://pfizer.wd1.myworkdayjobs.com/PfizerCareers/job/United-States—Missouri—St-Louis— Chesterfield/Senior-Scientist–BRD-Pilot-Plant_4779170-1
**Alumni connection! Let Kate Stuart know if you apply!
The Senior Scientist is a position within the Bioprocess Research & Development (BRD) group responsible for technical engineering leadership in the non-GMP Pilot space for manufacturing drug substances derived from mammalian and microbial culture process, including vaccines. As a senior scientist, this individual works with project teams to ensure proper technical transfer of incoming complex processes (both upstream and downstream) and oversees technical operations areas for these projects in the pilot area. The Senior Scientist will work closely with the pilot technicians to provide appropriate batch records and instructions and ensure that all unit operations are completed to meet on-time delivery of key drug substance supplies. This position also requires fostering strong relationships with other groups within Pfizer including Pfizer Global Supply and Global Workplace Solutions, and working collaboratively with other Biopharma and vendor companies on industry wide challenges and technologies.
This position is responsible for identifying efficiency improvements from an engineering perspective, and planning and supervising the implementation of these improvements within the operational area. The individual should also be a leader in evaluating and implementing new technology. This position will provide support to the Director, Bioprocess R&D Manufacturing on strategic initiatives for BRD Manufacturing and will be responsible for driving technology and innovation projects for the group.
ROLE RESPONSIBILITIES
- Accountable for technical deliverables across BRD non-GMP Pilot Manufacturing Operations.
- Collaborates extensively with development labs and project teams to ensure proper transfer of technical processes to enable on-time manufacturing of critical drug substance development and regulatory toxicology supplies.
- Works with junior engineers, pilot technicians, and partner lines to address technical challenges in unit operations to meet demanding development timelines and objectives
- Acts as a highly-skilled technical resource for junior engineers in the group, with the ability to provide answers to technical questions for multiple modalities as well as a strategic vision for how to address future technical challenges.
- Actively identifies target areas for increased business efficiency and provides novel solutions to enhance the pilot digital strategy.
- Coordinates the overall technology and innovation strategy of the pilot group.
BASIC QUALIFICATIONS
- PhD with 0-3 years of experience, Master’s Degree 3-6 years of experience or Bachelor’s Degree with 6-10 years of experience with a degree in the area of Chemical/Biochemical engineering, or Biology, Cell Biology, Biochemistry, Microbiology
- In depth technical and bioprocess unit operation expertise and extensive technical knowledge of all unit operations across the breadth of modalities encountered in a biologics pilot plant.
- Extensive experience in technical transfer and scale-up of the above unit operations, including to external CMOs.
- Direct or matrix management and project management training/experience.
PREFERRED QUALIFICATIONS
- Collaborative, team-oriented leadership and management style.
- Prior experience supporting new or emerging bioprocess modalities and technologies.
- Demonstrated leadership within the engineering discipline, including key participation on multi-disciplinary manufacturing teams.
- Extensive theoretical and practical knowledge in a wide variety of heterologous expression systems with a focus on E. coli, CHO, and HEK cells.
- Experience developing and executing relevant recovery and purification processes derived from microbial and/or mammalian production cultures, including vaccine and conjugation technology.
- General knowledge of GMP and Biotechnology CMC regulatory requirements.
ADDITIONAL INFORMATION
- Last Date to Apply: April 15, 2020