Job Opportunity: Postdoctoral Fellowship in Tumor Immunology and Immunotherapy, UC San Diego, CA
The labs of Dr. AP Ganesan and Dr. P Vijayanand are seeking a highly motivated postdoctoral scientist to undertake research in tumor immunology to investigate novel therapeutic targets for cancer immunotherapy and translation to the clinic. The candidate will work under the joint mentorship of Dr. Ganesan (oncologist/physician scientist; Assistant Professor, UCSD) and Dr. Vijayanand (Professor, LJI).
https://www.rchsd.org/doctors/a-preethi-ganesan-md-phd (lab site under reconstruction)
https://www.lji.org/labs/vijayanand/
Research focus
To investigate molecular and cellular mechanisms of anti-tumor immunity and test novel immunotherapy targets using cutting-edge genomic and immunological tools and mouse models
Requirements
• Ph.D. or MD/PhD in immunology
• Previous experience in murine work and in vivo experiments using mouse models
• Experience with tumor models, brain tumor models, leukemia models is desirable
Publications to review:
1. Upadhye A, Meza Landeros KE, Ramírez-Suástegui C, Schmiedel BJ, Woo E, Chee SJ, Malicki D, Coufal NG, Gonda D, Levy ML, Greenbaum JA, Seumois G, Crawford J, Roberts WD, Schoenberger SP, Cheroutre H, Ottensmeier CH, Vijayanand P, Ganesan AP. Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties. Nat Cancer. 2024. Epub 2024/01/17. doi: 10.1038/s43018-023-00706-9. PubMed PMID: 38228835.
2. Clarke J, Panwar B, Madrigal A, Singh D, Gujar R, Wood O, Chee SJ, Eschweiler S, King EV, Awad AS, Hanley CJ, McCann KJ, Bhattacharyya S, Woo E, Alzetani A, Seumois G, Thomas GJ, Ganesan AP, Friedmann PS, Sanchez-Elsner T, Ay F, Ottensmeier CH, Vijayanand P. Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer. J Exp Med. 2019 Sep 2;216(9):2128- 2149. doi: 10.1084/jem.20190249. Epub 2019 Jun 21.
3. Ganesan AP, Clarke J, Wood O, Garrido-Martin EM, Chee SJ, Mellows T, Samaniego-Castruita D, Singh D, Seumois G, Alzetani A, Woo E, Friedmann PS, King EV, Thomas GJ, Sanchez-Elsner T, Vijayanand P, Ottensmeier CH. Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer. Nature Immunology. 2017 Jun 19. doi:10.1038/ni.3775
4. Eschweiler, S., Clarke, J., Ramirez-Suastegui, C., Panwar, B., Madrigal, A., Chee, S. J., Karydis, I., Woo, E., Alzetani, A., Elsheikh, S., Hanley, C. J., Thomas, G. J., Friedmann, P. S., Sanchez-Elsner, T., Ay, F., Ottensmeier, C. H. & Vijayanand, P. Intratumoral follicular regulatory T cells curtail anti-PD-1 treatment efficacy. Nat Immunol 22, 1052-1063, doi:10.1038/s41590-021-00958-6 (2021).
5. Eschweiler S, Ramírez-Suástegui C, Li Y, King E, Chudley L, Thomas J, Wood O, von Witzleben A, Jeffrey D, McCann K, Simon H, Mondal M, Wang A, Dicker M, Lopez-Guadamillas E, Chou TF, Dobbs NA, Essame L, Acton G, Kelly F, Halbert G, Sacco JJ, Schache AG, Shaw R, McCaul JA, Paterson C, Davies JH, Brennan PA, Singh RP, Loadman PM, Wilson W, Hackshaw A, Seumois G, Okkenhaug K, Thomas GJ, Jones TM, Ay F, Friberg G, Kronenberg M, Vanhaesebroeck B, Vijayanand P, Ottensmeier CH. Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs. Nature. 2022 May;605(7911):741-746. PMID: 35508656; PMCID: PMC913277.
How to apply:
Interested applicants should submit a CV, a statement of research interests and contact information of 2-3 references to aganesan@health.ucsd.edu. The candidate’s work location will be LJI and employment will be through UC San Diego. Here is the link to information and terms of service for postdoc appointments at UCSD: https://postdoc.ucsd.edu/postdocs/index.html
About LJI & UC San Diego:
The LJI and UCSD contribute to the excellent scientific environment on the San Diego “mesa” which also comprises the Scripps Research Institute, the Sanford Consortium, the Sanford-Burnham and the Salk Institute.
LJI has been ranked as one of the best places to work in San Diego by the San Diego Business Journal. The Institute hosts 24 world-renowned faculty and over 100 postdoctoral researchers hailing from 21+ different countries. LJI is located in the Science Research Park on the campus
of UC San Diego, with easy access to the San Diego life sciences community and all that the area has to offer. In addition to your research training at LJI, UCSD Office of Postdoctoral and Research Scholar Affairs offers professional development and career training opportunities to ensure you achieve the highest level of academic and research excellence. We invite you to visit the website https://postdoc.ucsd.edu/about/index.html to learn more about their programs.
LJI and UCSD provide Equal Employment Opportunity (EEO) to all employees and applicants regardless of race, national origin, religion, sex, marital status, age, mental or physical disability, medical condition, veteran status, sexual orientation, or pregnancy. This applies to all personnel practices, including recruitment, hiring, training, promotion, compensation, benefits, transfers, educational assistance, and social and recreational programs.