Italo Biaggioni, M.D.

Italo Biaggioni, M.D.

Professor of Medicine
David Robertson, M.D. Professorship in Autonomic Disorders

: italo.biaggioni@vanderbilt.edu
: (615) 936-3420
: Vanderbilt University
Nashville, Tennessee - 37232

Research Description

My basic research focuses on the clinical and molecular pharmacology of adenosine, and its role in normal physiology and disease states. In particular, we are interested in the role of adenosine A2B receptors in pulmonary (inflammation, asthma) and cardiovascular (angiogenesis, cell base therapies) disorders. Our studies vary from whole animal studies, inclusing genetic ablation models, to cell cultures and intracellular pathways. Our ultimate goal is to develop therapies that target adenosine receptors.

Selected Publications

Biaggioni I, Calhoun DA. Sympathetic Activity, Hypertension, and The Importance of a Good Night’s Sleep. Hypertension [print-electronic]. 2016 Oct 10/3/2016; PMID: 27698060, PII: HYPERTENSIONAHA.116.08324, DOI: 10.1161/HYPERTENSIONAHA.116.08324, ISSN: 1524-4563.
Gamboa A, Figueroa R, Paranjape SY, Farley G, Diedrich A, Biaggioni I. Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension. Hypertension [print-electronic]. 2016 Oct; 68(4): 1004-10. PMID: 27528067, PMCID: PMC5016238, PII: HYPERTENSIONAHA.116.07681, DOI: 10.1161/HYPERTENSIONAHA.116.07681, ISSN: 1524-4563.
Okamoto LE, Diedrich A, Baudenbacher FJ, Harder R, Whitfield JS, Iqbal F, Gamboa A, Shibao CA, Black BK, Raj SR, Robertson D, Biaggioni I. Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine. Hypertension [print-electronic]. 2016 Aug; 68(2): 418-26. PMID: 27271310, PMCID: PMC4945429, PII: HYPERTENSIONAHA.116.07199, DOI: 10.1161/HYPERTENSIONAHA.116.07199, ISSN: 1524-4563.
Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA. A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition. J. Clin. Endocrinol. Metab [print-electronic]. 2016 May 5/4/2016; jc20161294. PMID: 27144937, DOI: 10.1210/jc.2016-1294, ISSN: 1945-7197.
Mar PL, Nwazue V, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Loyd JE, Hemnes AR, Robbins IM, Robertson D, Raj SR, Austin ED. Valsalva Maneuver in Pulmonary Arterial Hypertension: Susceptibility to Syncope and Autonomic Dysfunction. Chest [print-electronic]. 2016 May; 149(5): 1252-60. PMID: 26836906, PII: S0012-3692(15)00181-6, DOI: 10.1016/j.chest.2015.11.015, ISSN: 1931-3543.
Williams IM, Otero YF, Bracy DP, Wasserman DH, Biaggioni I, Arnold AC. Chronic Angiotensin-(1-7) Improves Insulin Sensitivity in High-Fat Fed Mice Independent of Blood Pressure. Hypertension [print-electronic]. 2016 May; 67(5): 983-91. PMID: 26975707, PMCID: PMC4833535, PII: HYPERTENSIONAHA.115.06935, DOI: 10.1161/HYPERTENSIONAHA.115.06935, ISSN: 1524-4563.
Eckberg DL, Cooke WH, Diedrich A, Biaggioni I, Buckey JC, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG. Respiratory modulation of human autonomic function on Earth. J. Physiol. (Lond.) [print-electronic]. 2016 Mar 3/29/2016; PMID: 27028958, DOI: 10.1113/JP271654, ISSN: 1469-7793.
Eckberg DL, Diedrich A, Cooke WH, Biaggioni I, Buckey JC, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG. Respiratory modulation of human autonomic function. Long-term neuroplasticity in space. J. Physiol. (Lond.) [print-electronic]. 2016 Mar 3/29/2016; PMID: 27029027, DOI: 10.1113/JP271656, ISSN: 1469-7793.
Bagai K, Peltier A, Malow B, Diedrich A, Shibao CA, Black BK, Paranjape SY, Orozco C, Biaggioni I, Robertson D, Raj SR. Objective Sleep Assessments in patients with Postural Tachycardia Syndrome using Overnight Polysomnograms. J Clin Sleep Med [print-electronic]. 2016 Feb 2/29/2016; PMID: 26951415, PII: jc-00367-15, ISSN: 1550-9397.
Kaufman MR, Chang-Kit L, Raj SR, Black BK, Milam DF, Reynolds WS, Biaggioni I, Robertson D, Dmochowski RR. Overactive bladder and autonomic dysfunction: Lower urinary tract symptoms in females with postural tachycardia syndrome. Neurourol. Urodyn [print-electronic]. 2016 Feb 2/9/2016; PMID: 26859225, DOI: 10.1002/nau.22971, ISSN: 1520-6777.
Arnold AC, Okamoto LE, Gamboa A, Black BK, Raj SR, Elijovich F, Robertson D, Shibao CA, Biaggioni I. Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure. Hypertension [print-electronic]. 2016 Feb; 67(2): 424-9. PMID: 26644241, PMCID: PMC4748950, PII: HYPERTENSIONAHA.115.06617, DOI: 10.1161/HYPERTENSIONAHA.115.06617, ISSN: 1524-4563.
Okamoto LE, Raj SR, Gamboa A, Shibao CA, Arnold AC, Garland EM, Black BK, Farley G, Diedrich A, Biaggioni I. Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2015 Dec 12/15/2015; 309(12): H2098-107. PMID: 26453329, PMCID: PMC4698423, PII: ajpheart.00409.2015, DOI: 10.1152/ajpheart.00409.2015, ISSN: 1522-1539.
Marinos A, Celedonio JE, Ramirez CE, Gottlieb J, Gamboa A, Hui N, Yu C, Stein CM, Biaggioni I, Shibao CA. Time-Course Analysis of Flow Mediated Dilation for the Evaluation of Endothelial Function After a High-Fat Meal in African Americans. J Am Heart Assoc. 2015 Nov; 4(11): PMID: 26541392, PMCID: PMC4845211, PII: JAHA.115.002388, DOI: 10.1161/JAHA.115.002388, ISSN: 2047-9980.
Celedonio JE, Arnold AC, Dupont WD, Ramirez CE, Diedrich A, Okamoto LE, Raj SR, Robertson D, Peltier AC, Biaggioni I, Shibao CA. Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure. Clin. Auton. Res [print-electronic]. 2015 Oct; 25(5): 309-15. PMID: 26359268, PMCID: PMC4785595, PII: 10.1007/s10286-015-0307-9, DOI: 10.1007/s10286-015-0307-9, ISSN: 1619-1560.
Mar PL, Shibao CA, Garland EM, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Robertson D, Raj SR. Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline). Clin. Sci. 2015 Jul; 129(2): 107-16. PMID: 25706983, PMCID: PMC4417057, PII: CS20140766, DOI: 10.1042/CS20140766, ISSN: 1470-8736.
Jordan J, Shibao C, Biaggioni I. Multiple system atrophy: using clinical pharmacology to reveal pathophysiology. Clin. Auton. Res [print-electronic]. 2015 Feb; 25(1): 53-9. PMID: 25757803, PMCID: PMC4431657, DOI: 10.1007/s10286-015-0271-4, ISSN: 1619-1560.
Palma JA, Fernandez-Cordon C, Coon EA, Low PA, Miglis MG, Jaradeh S, Bhaumik AK, Dayalu P, Urrestarazu E, Iriarte J, Biaggioni I, Kaufmann H. Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis. Clin. Auton. Res [print-electronic]. 2015 Feb; 25(1): 69-75. PMID: 25739474, PMCID: PMC4406814, DOI: 10.1007/s10286-015-0279-9, ISSN: 1619-1560.
Biaggioni I, Freeman R, Mathias CJ, Low P, Hewitt LA, Kaufmann H, . Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension [print-electronic]. 2015 Jan; 65(1): 101-7. PMID: 25350981, PMCID: PMC4354798, PII: HYPERTENSIONAHA.114.04035, DOI: 10.1161/HYPERTENSIONAHA.114.04035, ISSN: 1524-4563.
Biaggioni I. Treatment: special conditions: orthostatic hypotension. J Am Soc Hypertens [print-electronic]. 2015 Jan; 9(1): 67-9; quiz 70. PMID: 25641107, PII: S1933-1711(14)00903-6, DOI: 10.1016/j.jash.2014.12.005, ISSN: 1878-7436.
Arnold AC, Haman K, Garland EM, Raj V, Dupont WD, Biaggioni I, Robertson D, Raj SR. Cognitive dysfunction in postural tachycardia syndrome. Clin. Sci. 2015 Jan; 128(1): 39-45. PMID: 25001527, PMCID: PMC4161607, PII: CS20140251, DOI: 10.1042/CS20140251, ISSN: 1470-8736.
Kpaeyeh J, Mar PL, Raj V, Black BK, Arnold AC, Biaggioni I, Shibao CA, Paranjape SY, Dupont WD, Robertson D, Raj SR. Hemodynamic profiles and tolerability of modafinil in the treatment of postural tachycardia syndrome: a randomized, placebo-controlled trial. J Clin Psychopharmacol. 2014 Dec; 34(6): 738-41. PMID: 25222185, PMCID: PMC4239166, DOI: 10.1097/JCP.0000000000000221, ISSN: 1533-712X.
Okamoto LE, Gamboa A, Shibao CA, Arnold AC, Choi L, Black BK, Raj SR, Robertson D, Biaggioni I. Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension. Hypertension [print-electronic]. 2014 Dec; 64(6): 1241-7. PMID: 25267802, PMCID: PMC4230998, PII: HYPERTENSIONAHA.114.04116, DOI: 10.1161/HYPERTENSIONAHA.114.04116, ISSN: 1524-4563.
Ramirez CE, Okamoto LE, Arnold AC, Gamboa A, Diedrich A, Choi L, Raj SR, Robertson D, Biaggioni I, Shibao CA. Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure. Hypertension [print-electronic]. 2014 Dec; 64(6): 1235-40. PMID: 25185131, PMCID: PMC4231172, PII: HYPERTENSIONAHA.114.04225, DOI: 10.1161/HYPERTENSIONAHA.114.04225, ISSN: 1524-4563.
Biaggioni I. New developments in the management of neurogenic orthostatic hypotension. Curr Cardiol Rep. 2014 Nov; 16(11): 542. PMID: 25303896, DOI: 10.1007/s11886-014-0542-z, ISSN: 1534-3170.
Gamboa A, Okamoto LE, Arnold AC, Figueroa RA, Diedrich A, Raj SR, Paranjape SY, Farley G, Abumrad N, Biaggioni I. Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension [print-electronic]. 2014 Oct; 64(4): 867-74. PMID: 25001269, PMCID: PMC4162826, PII: HYPERTENSIONAHA.114.03738, DOI: 10.1161/HYPERTENSIONAHA.114.03738, ISSN: 1524-4563.
Figueroa RA, Arnold AC, Nwazue VC, Okamoto LE, Paranjape SY, Black BK, Diedrich A, Robertson D, Biaggioni I, Raj SR, Gamboa A. Acute volume loading and exercise capacity in postural tachycardia syndrome. J. Appl. Physiol [print-electronic]. 2014 Sep 9/15/2014; 117(6): 663-8. PMID: 25059240, PMCID: PMC4157162, PII: japplphysiol.00367.2014, DOI: 10.1152/japplphysiol.00367.2014, ISSN: 1522-1601.
Ryzhov S, Sung BH, Zhang Q, Weaver A, Gumina RJ, Biaggioni I, Feoktistov I. Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation. Purinergic Signal [print-electronic]. 2014 Sep; 10(3): 477-86. PMID: 24584483, PMCID: PMC4152448, DOI: 10.1007/s11302-014-9410-y, ISSN: 1573-9546.
Biaggioni I. Ginseng for cardiovascular disease. Not yet the panacea [editorial]. J Am Soc Hypertens [print-electronic]. 2014 Aug; 8(8): 599-600. PMID: 25151321, PII: S1933-1711(14)00592-0, DOI: 10.1016/j.jash.2014.05.012, ISSN: 1878-7436.
Kaufmann H, Freeman R, Biaggioni I, Low P, Pedder S, Hewitt LA, Mauney J, Feirtag M, Mathias CJ, . Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology [print-electronic]. 2014 Jul 7/22/2014; 83(4): 328-35. PMID: 24944260, PMCID: PMC4115605, PII: WNL.0000000000000615, DOI: 10.1212/WNL.0000000000000615, ISSN: 1526-632X.
Green EA, Black BK, Biaggioni I, Paranjape SY, Bagai K, Shibao C, Okoye MC, Dupont WD, Robertson D, Raj SR. Melatonin reduces tachycardia in postural tachycardia syndrome: a randomized, crossover trial. Cardiovasc Ther. 2014 Jun; 32(3): 105-12. PMID: 24495468, PMCID: PMC3999238, DOI: 10.1111/1755-5922.12067, ISSN: 1755-5922.
Nwazue VC, Arnold AC, Raj V, Black BK, Biaggioni I, Paranjape SY, Orozco C, Dupont WD, Robertson D, Raj SR. Understanding the placebo effect in clinical trials for postural tachycardia syndrome. Clin. Exp. Pharmacol. Physiol. 2014 May; 41(5): 325-30. PMID: 24606242, PMCID: PMC4005784, DOI: 10.1111/1440-1681.12221, ISSN: 1440-1681.
Shibao C, Muppa P, Semler MW, Peltier AC, Biaggioni I. A standing dilemma: autonomic failure preceding Hodgkin’s lymphoma. Am. J. Med [print-electronic]. 2014 Apr; 127(4): 284-7. PMID: 24333616, PMCID: PMC4099002, PII: S0002-9343(13)01026-7, DOI: 10.1016/j.amjmed.2013.12.002, ISSN: 1555-7162.
Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR. Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol [print-electronic]. 2014 Mar; 13(3): 268-75. PMID: 24507091, PMCID: PMC4030757, PII: S1474-4422(13)70301-6, DOI: 10.1016/S1474-4422(13)70301-6, ISSN: 1474-4465.
Ferguson MC, Garland EM, Hedges L, Womack-Nunley B, Hamid R, Phillips JA, Shibao CA, Raj SR, Biaggioni I, Robertson D. SHC2 gene copy number in multiple system atrophy (MSA). Clin. Auton. Res [print-electronic]. 2014 Feb; 24(1): 25-30. PMID: 24170347, PMCID: PMC3946192, DOI: 10.1007/s10286-013-0216-8, ISSN: 1619-1560.
Mar PL, Raj V, Black BK, Biaggioni I, Shibao CA, Paranjape SY, Dupont WD, Robertson D, Raj SR. Acute hemodynamic effects of a selective serotonin reuptake inhibitor in postural tachycardia syndrome: a randomized, crossover trial. J. Psychopharmacol. (Oxford) [print-electronic]. 2014 Feb; 28(2): 155-61. PMID: 24227635, PMCID: PMC3956655, PII: 0269881113512911, DOI: 10.1177/0269881113512911, ISSN: 1461-7285.
Arnold AC, Ramirez CE, Choi L, Okamoto LE, Gamboa A, Diedrich A, Raj SR, Robertson D, Biaggioni I, Shibao CA. Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure. Front Physiol. 2014; 5: 270. PMID: 25104940, PMCID: PMC4109567, DOI: 10.3389/fphys.2014.00270, ISSN: 1664-042X.
Nwazue VC, Paranjape SY, Black BK, Biaggioni I, Diedrich A, Dupont WD, Robertson D, Raj SR. Postural tachycardia syndrome and inappropriate sinus tachycardia: role of autonomic modulation and sinus node automaticity. J Am Heart Assoc. 2014; 3(2): e000700. PMID: 24721800, PMCID: PMC4187519, PII: jah3500, DOI: 10.1161/JAHA.113.000700, ISSN: 2047-9980.
Ryzhov S, Biktasova A, Goldstein AE, Zhang Q, Biaggioni I, Dikov MM, Feoktistov I. Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Mol. Pharmacol [print-electronic]. 2014 Jan; 85(1): 62-73. PMID: 24136993, PMCID: PMC3868903, PII: mol.113.088567, DOI: 10.1124/mol.113.088567, ISSN: 1521-0111.
Bagai K, Wakwe CI, Malow B, Black BK, Biaggioni I, Paranjape SY, Orozco C, Raj SR. Estimation of sleep disturbances using wrist actigraphy in patients with postural tachycardia syndrome. Auton Neurosci [print-electronic]. 2013 Oct; 177(2): 260-5. PMID: 23538032, PMCID: PMC3700681, PII: S1566-0702(13)00056-8, DOI: 10.1016/j.autneu.2013.02.021, ISSN: 1872-7484.
Green EA, Raj V, Shibao CA, Biaggioni I, Black BK, Dupont WD, Robertson D, Raj SR. Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome. J Am Heart Assoc. 2013 Oct; 2(5): e000395. PMID: 24002370, PMCID: PMC3835251, PII: jah3299, DOI: 10.1161/JAHA.113.000395, ISSN: 2047-9980.
Ryzhov S, Zhang Q, Biaggioni I, Feoktistov I. Adenosine A2B receptors on cardiac stem cell antigen (Sca)-1-positive stromal cells play a protective role in myocardial infarction. Am. J. Pathol [print-electronic]. 2013 Sep; 183(3): 665-72. PMID: 23827818, PMCID: PMC3763763, PII: S0002-9440(13)00398-2, DOI: 10.1016/j.ajpath.2013.05.012, ISSN: 1525-2191.
Shibao C, Lipsitz LA, Biaggioni I, . Evaluation and treatment of orthostatic hypotension. J Am Soc Hypertens [print-electronic]. 2013 Jul; 7(4): 317-24. PMID: 23721882, PMCID: PMC3769179, PII: S1933-1711(13)00074-0, DOI: 10.1016/j.jash.2013.04.006.
Arnold AC, Okamoto LE, Diedrich A, Paranjape SY, Raj SR, Biaggioni I, Gamboa A. Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study. Neurology [print-electronic]. 2013 May 5/21/2013; 80(21): 1927-33. PMID: 23616163, PMCID: PMC3716342, PII: WNL.0b013e318293e310, DOI: 10.1212/WNL.0b013e318293e310, ISSN: 1526-632X.
Arnold AC, Okamoto LE, Gamboa A, Shibao C, Raj SR, Robertson D, Biaggioni I. Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure. Hypertension [print-electronic]. 2013 Mar; 61(3): 701-6. PMID: 23266540, PMCID: PMC3573256, PII: HYPERTENSIONAHA.111.00377, DOI: 10.1161/HYPERTENSIONAHA.111.00377, ISSN: 1524-4563.
Shibao C, Lipsitz LA, Biaggioni I. ASH position paper: evaluation and treatment of orthostatic hypotension. J Clin Hypertens (Greenwich) [print-electronic]. 2013 Mar; 15(3): 147-53. PMID: 23458585, DOI: 10.1111/jch.12062, ISSN: 1751-7176.
Gamboa A, Okamoto LE, Raj SR, Diedrich A, Shibao CA, Robertson D, Biaggioni I. Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects. Hypertension [print-electronic]. 2013 Feb; 61(2): 376-81. PMID: 23283362, PMCID: PMC3621717, PII: HYPERTENSIONAHA.111.00203, DOI: 10.1161/HYPERTENSIONAHA.111.00203, ISSN: 1524-4563.
Plash WB, Diedrich A, Biaggioni I, Garland EM, Paranjape SY, Black BK, Dupont WD, Raj SR. Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamics. Clin. Sci. 2013 Jan; 124(2): 109-14. PMID: 22931296, PMCID: PMC3478101, PII: CS20120276, DOI: 10.1042/CS20120276, ISSN: 1470-8736.
Jordan J, Biaggioni I. Genetic influences on human baroreflex regulation. Auton Neurosci [print-electronic]. 2012 Dec 12/24/2012; 172(1-2): 23-5. PMID: 23167991, PII: S1566-0702(12)00179-8, DOI: 10.1016/j.autneu.2012.10.011, ISSN: 1872-7484.
Arnold AC, Biaggioni I. Management approaches to hypertension in autonomic failure. Curr. Opin. Nephrol. Hypertens. 2012 Sep; 21(5): 481-5. PMID: 22801444, PMCID: PMC3732047, DOI: 10.1097/MNH.0b013e328356c52f, ISSN: 1473-6543.
Coffin ST, Black BK, Biaggioni I, Paranjape SY, Orozco C, Black PW, Dupont WD, Robertson D, Raj SR. Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrome. Heart Rhythm [print-electronic]. 2012 Sep; 9(9): 1484-90. PMID: 22561596, PMCID: PMC3419341, PII: S1547-5271(12)00483-3, DOI: 10.1016/j.hrthm.2012.05.002, ISSN: 1556-3871.
Byrne DW, Biaggioni I, Bernard GR, Helmer TT, Boone LR, Pulley JM, Edwards T, Dittus RS. Clinical and translational research studios: a multidisciplinary internal support program. Acad Med. 2012 Aug; 87(8): 1052-9. PMID: 22722360, PMCID: PMC3406254, DOI: 10.1097/ACM.0b013e31825d29d4, ISSN: 1938-808X.
Ryzhov S, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I. Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells. J. Pharmacol. Exp. Ther [print-electronic]. 2012 Jun; 341(3): 764-74. PMID: 22431204, PMCID: PMC3362889, PII: jpet.111.190835, DOI: 10.1124/jpet.111.190835, ISSN: 1521-0103.
Shibao C, Okamoto L, Biaggioni I. Pharmacotherapy of autonomic failure. Pharmacol. Ther [print-electronic]. 2012 Jun; 134(3): 279-86. PMID: 21664375, PMCID: PMC3358114, PII: S0163-7258(11)00120-3, DOI: 10.1016/j.pharmthera.2011.05.009, ISSN: 1879-016X.
Shibao C, Buchowski MS, Chen KY, Yu C, Biaggioni I. Chronic sympathetic attenuation and energy metabolism in autonomic failure. Hypertension [print-electronic]. 2012 May; 59(5): 985-90. PMID: 22469621, PMCID: PMC3383057, PII: HYPERTENSIONAHA.111.190157, DOI: 10.1161/HYPERTENSIONAHA.111.190157, ISSN: 1524-4563.
Gamboa A, Okamoto LE, Diedrich A, Choi L, Robertson D, Farley G, Paranjape S, Biaggioni I. Sympathetic activation and nitric oxide function in early hypertension. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2012 Apr 4/1/2012; 302(7): H1438-43. PMID: 22287587, PMCID: PMC3330790, PII: ajpheart.01020.2011, DOI: 10.1152/ajpheart.01020.2011, ISSN: 1522-1539.
Okamoto LE, Shibao C, Gamboa A, Choi L, Diedrich A, Raj SR, Black BK, Robertson D, Biaggioni I. Synergistic effect of norepinephrine transporter blockade and a-2 antagonism on blood pressure in autonomic failure. Hypertension [print-electronic]. 2012 Mar; 59(3): 650-6. PMID: 22311903, PMCID: PMC3312003, PII: HYPERTENSIONAHA.111.184812, DOI: 10.1161/HYPERTENSIONAHA.111.184812, ISSN: 1524-4563.
Biaggioni I. Interventional approaches to reduce sympathetic activity in resistant hypertension: to ablate or stimulate? [editorial]. Hypertension [print-electronic]. 2012 Feb; 59(2): 194-5. PMID: 22184323, PII: HYPERTENSIONAHA.111.186809, DOI: 10.1161/HYPERTENSIONAHA.111.186809, ISSN: 1524-4563.
Mustafa HI, Raj SR, Diedrich A, Black BK, Paranjape SY, Dupont WD, Williams GH, Biaggioni I, Robertson D. Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndrome. Circ Arrhythm Electrophysiol [print-electronic]. 2012 Feb; 5(1): 173-80. PMID: 22247480, PMCID: PMC3577936, PII: CIRCEP.111.965343, DOI: 10.1161/CIRCEP.111.965343, ISSN: 1941-3084.
Okamoto LE, Raj SR, Peltier A, Gamboa A, Shibao C, Diedrich A, Black BK, Robertson D, Biaggioni I. Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes. Clin. Sci. 2012 Feb; 122(4): 183-92. PMID: 21906029, PMCID: PMC3203411, PII: CS20110200, DOI: 10.1042/CS20110200, ISSN: 1470-8736.
Brewster JA, Garland EM, Biaggioni I, Black BK, Ling JF, Shibao CA, Robertson D, Raj SR. Diurnal variability in orthostatic tachycardia: implications for the postural tachycardia syndrome. Clin. Sci. 2012 Jan; 122(1): 25-31. PMID: 21751966, PMCID: PMC3172399, PII: CS20110077, DOI: 10.1042/CS20110077, ISSN: 1470-8736.
Mustafa HI, Fessel JP, Barwise J, Shannon JR, Raj SR, Diedrich A, Biaggioni I, Robertson D. Dysautonomia: perioperative implications. Anesthesiology. 2012 Jan; 116(1): 205-15. PMID: 22143168, PMCID: PMC3296831, DOI: 10.1097/ALN.0b013e31823db712, ISSN: 1528-1175.
Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn MR, Biaggioni I, Dikov MM, Feoktistov I. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells. J. Immunol [print-electronic]. 2011 Dec 12/1/2011; 187(11): 6120-9. PMID: 22039302, PMCID: PMC3221925, PII: jimmunol.1101225, DOI: 10.4049/jimmunol.1101225, ISSN: 1550-6606.
Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz IJ, Schondorf R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci [print-electronic]. 2011 Apr 4/26/2011; 161(1-2): 46-8. PMID: 21393070, PII: S1566-0702(11)00035-X, DOI: 10.1016/j.autneu.2011.02.004, ISSN: 1872-7484.
Bagai K, Song Y, Ling JF, Malow B, Black BK, Biaggioni I, Robertson D, Raj SR. Sleep disturbances and diminished quality of life in postural tachycardia syndrome. J Clin Sleep Med. 2011 Apr 4/15/2011; 7(2): 204-10. PMID: 21509337, PMCID: PMC3077350, ISSN: 1550-9397.
Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin. Auton. Res. 2011 Apr; 21(2): 69-72. PMID: 21431947, DOI: 10.1007/s10286-011-0119-5, ISSN: 1619-1560.
Kim CH, Leung A, Huh YH, Yang E, Kim DJ, Leblanc P, Ryu H, Kim K, Kim DW, Garland EM, Raj SR, Biaggioni I, Robertson D, Kim KS. Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase. J. Biol. Chem [print-electronic]. 2011 Mar 3/18/2011; 286(11): 9196-204. PMID: 21209083, PMCID: PMC3059068, PII: M110.192351, DOI: 10.1074/jbc.M110.192351, ISSN: 1083-351X.
Hollenbeck R, Black BK, Peltier AC, Biaggioni I, Robertson D, Winton EF, Raj SR. Long-term treatment with rituximab of autoimmune autonomic ganglionopathy in a patient with lymphoma. Arch. Neurol [print-electronic]. 2011 Mar; 68(3): 372-5. PMID: 21059985, PMCID: PMC3725638, PII: archneurol.2010.289, DOI: 10.1001/archneurol.2010.289, ISSN: 1538-3687.
Mustafa HI, Garland EM, Biaggioni I, Black BK, Dupont WD, Robertson D, Raj SR. Abnormalities of angiotensin regulation in postural tachycardia syndrome. Heart Rhythm [print-electronic]. 2011 Mar; 8(3): 422-8. PMID: 21266211, PMCID: PMC3050076, PII: S1547-5271(10)01204-X, DOI: 10.1016/j.hrthm.2010.11.009, ISSN: 1556-3871.
Feoktistov I, Biaggioni I. Role of adenosine A(2B) receptors in inflammation. Adv. Pharmacol. 2011; 61: 115-44. PMID: 21586358, PMCID: PMC3748596, PII: B978-0-12-385526-8.00005-9, DOI: 10.1016/B978-0-12-385526-8.00005-9, ISSN: 1557-8925.
Shibao C, Biaggioni I. Orthostatic hypotension and cardiovascular risk [editorial]. Hypertension [print-electronic]. 2010 Dec; 56(6): 1042-4. PMID: 21059992, PMCID: PMC3752681, PII: HYPERTENSIONAHA.110.162768, DOI: 10.1161/HYPERTENSIONAHA.110.162768, ISSN: 1524-4563.
Shibao C, Okamoto LE, Gamboa A, Yu C, Diedrich A, Raj SR, Robertson D, Biaggioni I. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension [print-electronic]. 2010 Nov; 56(5): 847-51. PMID: 20837887, PMCID: PMC2959129, PII: HYPERTENSIONAHA.110.154898, DOI: 10.1161/HYPERTENSIONAHA.110.154898, ISSN: 1524-4563.
McHugh J, Keller NR, Appalsamy M, Thomas SA, Raj SR, Diedrich A, Biaggioni I, Jordan J, Robertson D. Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control. Hypertension [print-electronic]. 2010 Jun; 55(6): 1438-43. PMID: 20385965, PMCID: PMC2965336, PII: HYPERTENSIONAHA.110.151860, DOI: 10.1161/HYPERTENSIONAHA.110.151860, ISSN: 1524-4563.
Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2010 May; 42(5): 564-71. PMID: 19556606, PMCID: PMC2874442, PII: 2008-0391OC, DOI: 10.1165/rcmb.2008-0391OC, ISSN: 1535-4989.
Peltier AC, Garland E, Raj SR, Sato K, Black B, Song Y, Wang L, Biaggioni I, Diedrich A, Robertson D. Distal sudomotor findings in postural tachycardia syndrome. Clin. Auton. Res [print-electronic]. 2010 Apr; 20(2): 93-9. PMID: 20035362, PMCID: PMC3089763, DOI: 10.1007/s10286-009-0045-y, ISSN: 1619-1560.
Peltier AC, Black BK, Raj SR, Donofrio P, Robertson D, Biaggioni I. Coexistent autoimmune autonomic ganglionopathy and myasthenia gravis associated with non-small-cell lung cancer. Muscle Nerve. 2010 Mar; 41(3): 416-9. PMID: 19882640, PMCID: PMC3925506, DOI: 10.1002/mus.21528, ISSN: 1097-4598.
Garland EM, Gamboa A, Okamoto L, Raj SR, Black BK, Davis TL, Biaggioni I, Robertson D. Renal impairment of pure autonomic failure. Hypertension [print-electronic]. 2009 Nov; 54(5): 1057-61. PMID: 19738158, PMCID: PMC2796115, PII: HYPERTENSIONAHA.109.136853, DOI: 10.1161/HYPERTENSIONAHA.109.136853, ISSN: 1524-4563.
Raj SR, Black BK, Biaggioni I, Paranjape SY, Ramirez M, Dupont WD, Robertson D. Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more. Circulation [print-electronic]. 2009 Sep 9/1/2009; 120(9): 725-34. PMID: 19687359, PMCID: PMC2758650, PII: CIRCULATIONAHA.108.846501, DOI: 10.1161/CIRCULATIONAHA.108.846501, ISSN: 1524-4539.
Ryzhov S, Zaynagetdinov R, Goldstein AE, Matafonov A, Biaggioni I, Feoktistov I. Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8. Purinergic Signal [print-electronic]. 2009 Sep; 5(3): 289-98. PMID: 19125355, PMCID: PMC2717310, DOI: 10.1007/s11302-008-9129-8, ISSN: 1573-9538.
Raj V, Haman KL, Raj SR, Byrne D, Blakely RD, Biaggioni I, Robertson D, Shelton RC. Psychiatric profile and attention deficits in postural tachycardia syndrome. J. Neurol. Neurosurg. Psychiatr [print-electronic]. 2009 Mar; 80(3): 339-44. PMID: 18977825, PMCID: PMC2758320, PII: jnnp.2008.144360, DOI: 10.1136/jnnp.2008.144360, ISSN: 1468-330X.
Okamoto LE, Gamboa A, Shibao C, Black BK, Diedrich A, Raj SR, Robertson D, Biaggioni I. Nocturnal blood pressure dipping in the hypertension of autonomic failure. Hypertension [print-electronic]. 2009 Feb; 53(2): 363-9. PMID: 19047577, PMCID: PMC2665259, PII: HYPERTENSIONAHA.108.124552, DOI: 10.1161/HYPERTENSIONAHA.108.124552, ISSN: 1524-4563.
Feoktistov I, Biaggioni I, Cronstein BN. Adenosine receptors in wound healing, fibrosis and angiogenesis. Handb Exp Pharmacol. 2009; (193): 383-97. PMID: 19639289, PMCID: PMC3729032, DOI: 10.1007/978-3-540-89615-9_13, ISSN: 0171-2004.
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, . Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med [print-electronic]. 2008 Nov 11/20/2008; 359(21): 2195-207. PMID: 18997196, PII: NEJMoa0807646, DOI: 10.1056/NEJMoa0807646, ISSN: 1533-4406.
Biaggioni I. Circadian clocks, autonomic rhythms, and blood pressure dipping [editorial]. Hypertension [print-electronic]. 2008 Nov; 52(5): 797-8. PMID: 18779437, PMCID: PMC2692022, PII: HYPERTENSIONAHA.108.117234, DOI: 10.1161/HYPERTENSIONAHA.108.117234, ISSN: 1524-4563.
Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood [print-electronic]. 2008 Sep 9/1/2008; 112(5): 1822-31. PMID: 18559975, PMCID: PMC2518889, PII: blood-2008-02-136325, DOI: 10.1182/blood-2008-02-136325, ISSN: 1528-0020.
Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, Dikov MM, Feoktistov I. Host A(2B) adenosine receptors promote carcinoma growth. Neoplasia. 2008 Sep; 10(9): 987-95. PMID: 18714400, PMCID: PMC2517644, ISSN: 1476-5586.
Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I. Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Hypertension [print-electronic]. 2008 Jun; 51(6): 1531-6. PMID: 18426998, PMCID: PMC2497433, PII: HYPERTENSIONAHA.107.105171, DOI: 10.1161/HYPERTENSIONAHA.107.105171, ISSN: 1524-4563.
Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. J. Immunol. 2008 Jun 6/1/2008; 180(11): 7212-20. PMID: 18490720, PMCID: PMC3628765, PII: 180/11/7212, ISSN: 0022-1767.
Ryzhov S, Solenkova NV, Goldstein AE, Lamparter M, Fleenor T, Young PP, Greelish JP, Byrne JG, Vaughan DE, Biaggioni I, Hatzopoulos AK, Feoktistov I. Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circ. Res [print-electronic]. 2008 Feb 2/15/2008; 102(3): 356-63. PMID: 18032734, PMCID: PMC2803108, PII: CIRCRESAHA.107.158147, DOI: 10.1161/CIRCRESAHA.107.158147, ISSN: 1524-4571.
Biaggioni I. Should we target the sympathetic nervous system in the treatment of obesity-associated hypertension?. Hypertension [print-electronic]. 2008 Feb; 51(2): 168-71. PMID: 18086947, PII: HYPERTENSIONAHA.107.090514, DOI: 10.1161/HYPERTENSIONAHA.107.090514, ISSN: 1524-4563.
Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines. J. Pharmacol. Exp. Ther [print-electronic]. 2008 Feb; 324(2): 694-700. PMID: 17965229, PII: jpet.107.131540, DOI: 10.1124/jpet.107.131540, ISSN: 1521-0103.
Shibao C, Garland EM, Gamboa A, Vnencak-Jones CL, Van Woeltz M, Haines JL, Yu C, Biaggioni I. PRNP M129V homozygosity in multiple system atrophy vs. Parkinson’s disease. Clin. Auton. Res [print-electronic]. 2008 Feb; 18(1): 13-9. PMID: 18236005, DOI: 10.1007/s10286-007-0447-7, ISSN: 0959-9851.
Shibao C, Grijalva CG, Raj SR, Biaggioni I, Griffin MR. Orthostatic hypotension-related hospitalizations in the United States. Am. J. Med. 2007 Nov; 120(11): 975-80. PMID: 17976425, PII: S0002-9343(07)00655-9, DOI: 10.1016/j.amjmed.2007.05.009, ISSN: 1555-7162.
Biaggioni I. The sympathetic nervous system and blood volume regulation: lessons from autonomic failure patients. Am. J. Med. Sci. 2007 Jul; 334(1): 61-4. PMID: 17630595, PII: 00000441-200707000-00021, DOI: 10.1097/MAJ.0b013e318065c03b, ISSN: 0002-9629.
Shibao C, Gamboa A, Diedrich A, Dossett C, Choi L, Farley G, Biaggioni I. Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure. Hypertension [print-electronic]. 2007 Jul; 50(1): 54-61. PMID: 17515447, PII: HYPERTENSIONAHA.107.091355, DOI: 10.1161/HYPERTENSIONAHA.107.091355, ISSN: 1524-4563.
Shibao C, Raj SR, Gamboa A, Diedrich A, Choi L, Black BK, Robertson D, Biaggioni I. Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function. Hypertension [print-electronic]. 2007 Jul; 50(1): 47-53. PMID: 17515448, PII: HYPERTENSIONAHA.107.089961, DOI: 10.1161/HYPERTENSIONAHA.107.089961, ISSN: 1524-4563.
Raj SR, Robertson D, Biaggioni I, Diedrich A. Abnormal valsalva maneuver is not always a sign of congestive heart failure [letter]. Am. J. Med. 2007 Jun; 120(6): e15-6. PMID: 17524733, PII: S0002-9343(06)00392-5, DOI: 10.1016/j.amjmed.2006.03.022, ISSN: 1555-7162.
Gamboa A, Diedrich A, Biaggioni I. Pharmacological probes to measure the importance of the autonomic nervous system [editorial]. Clin. Auton. Res. 2007 Apr; 17(2): 65-8. PMID: 17401762, DOI: 10.1007/s10286-007-0406-3, ISSN: 0959-9851.
Iwasaki K, Levine BD, Zhang R, Zuckerman JH, Pawelczyk JA, Diedrich A, Ertl AC, Cox JF, Cooke WH, Giller CA, Ray CA, Lane LD, Buckey JC, Baisch FJ, Eckberg DL, Robertson D, Biaggioni I, Blomqvist CG. Human cerebral autoregulation before, during and after spaceflight. J. Physiol. (Lond.) [print-electronic]. 2007 Mar 3/15/2007; 579(Pt 3): 799-810. PMID: 17185344, PMCID: PMC2151354, PII: jphysiol.2006.119636, DOI: 10.1113/jphysiol.2006.119636, ISSN: 0022-3751.
Brychta RJ, Shiavi R, Robertson D, Biaggioni I, Diedrich A. A simplified two-component model of blood pressure fluctuation. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2007 Feb; 292(2): H1193-203. PMID: 17012354, PMCID: PMC1987355, PII: 00645.2006, DOI: 10.1152/ajpheart.00645.2006, ISSN: 0363-6135.
Ryzhov S, McCaleb JL, Goldstein AE, Biaggioni I, Feoktistov I. Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia. J. Pharmacol. Exp. Ther [print-electronic]. 2007 Feb; 320(2): 565-72. PMID: 17132813, PII: jpet.106.114850, DOI: 10.1124/jpet.106.114850, ISSN: 0022-3565.
Biaggioni I. Parkinson’s disease: autonomic neuronopathy with impaired cardiovascular regulation [editorial]. Hypertension [print-electronic]. 2007 Jan; 49(1): 21-2. PMID: 17101846, PII: 01.HYP.0000250920.38461.ed, DOI: 10.1161/01.HYP.0000250920.38461.ed, ISSN: 1524-4563.
Biaggioni I. Autonomic/metabolic interactions modulating the exercise pressor reflex: the purinergic hypothesis. J. Physiol. (Lond.) [print-electronic]. 2007 Jan 1/1/2007; 578(Pt 1): 5-6. PMID: 17110407, PMCID: PMC2075115, PII: jphysiol.2006.124552, DOI: 10.1113/jphysiol.2006.124552, ISSN: 0022-3751.
Gamboa A, Shibao C, Diedrich A, Choi L, Pohar B, Jordan J, Paranjape S, Farley G, Biaggioni I. Contribution of endothelial nitric oxide to blood pressure in humans. Hypertension [print-electronic]. 2007 Jan; 49(1): 170-7. PMID: 17130304, PII: 01.HYP.0000252425.06216.26, DOI: 10.1161/01.HYP.0000252425.06216.26, ISSN: 1524-4563.
Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, Farley G, Paranjape SY, Davis SN, Biaggioni I. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension [print-electronic]. 2007 Jan; 49(1): 27-33. PMID: 17116758, PII: 01.HYP.0000251679.87348.05, DOI: 10.1161/01.HYP.0000251679.87348.05, ISSN: 1524-4563.
Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown NJ. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J. Pharmacol. Exp. Ther [print-electronic]. 2006 Sep; 318(3): 1287-92. PMID: 16772538, PII: jpet.106.104026, DOI: 10.1124/jpet.106.104026, ISSN: 0022-3565.
Raj SR, Biaggioni I, Black BK, Rali A, Jordan J, Taneja I, Harris PA, Robertson D. Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension. Hypertension [print-electronic]. 2006 Aug; 48(2): 329-34. PMID: 16785332, PII: 01.HYP.0000229906.27330.4f, DOI: 10.1161/01.HYP.0000229906.27330.4f, ISSN: 1524-4563.
Ryzhov S, Goldstein AE, Biaggioni I, Feoktistov I. Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells. Mol. Pharmacol [print-electronic]. 2006 Aug; 70(2): 727-35. PMID: 16707627, PII: mol.106.022780, DOI: 10.1124/mol.106.022780, ISSN: 0026-895X.
Voustianiouk A, Kaufmann H, Diedrich A, Raphan T, Biaggioni I, Macdougall H, Ogorodnikov D, Cohen B. Electrical activation of the human vestibulo-sympathetic reflex. Exp Brain Res [print-electronic]. 2006 May; 171(2): 251-61. PMID: 16308690, DOI: 10.1007/s00221-005-0266-9, ISSN: 0014-4819.
Shibao C, Gamboa A, Diedrich A, Biaggioni I. Management of hypertension in the setting of autonomic dysfunction. Curr Treat Options Cardiovasc Med. 2006 Apr; 8(2): 105-9. PMID: 16533484, ISSN: 1092-8464.
Jacob G, Garland EM, Costa F, Stein CM, Xie HG, Robertson RM, Biaggioni I, Robertson D. Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome. Hypertension [print-electronic]. 2006 Mar; 47(3): 421-7. PMID: 16461848, PII: 01.HYP.0000205120.46149.34, DOI: 10.1161/01.HYP.0000205120.46149.34, ISSN: 1524-4563.
Shibao C, Gamboa A, Abraham R, Raj SR, Diedrich A, Black B, Robertson D, Biaggioni I. Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure. Hypertension [print-electronic]. 2006 Mar; 47(3): 522-6. PMID: 16391172, PII: 01.HYP.0000199982.71858.11, DOI: 10.1161/01.HYP.0000199982.71858.11, ISSN: 1524-4563.
Dhalla AK, Wong MY, Wang WQ, Biaggioni I, Belardinelli L. Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats. J. Pharmacol. Exp. Ther [print-electronic]. 2006 Feb; 316(2): 695-702. PMID: 16227469, PII: jpet.105.095323, DOI: 10.1124/jpet.105.095323, ISSN: 0022-3565.
Strickberger SA, Benson DW, Biaggioni I, Callans DJ, Cohen MI, Ellenbogen KA, Epstein AE, Friedman P, Goldberger J, Heidenreich PA, Klein GJ, Knight BP, Morillo CA, Myerburg RJ, Sila CA, , , , , . AHA/ACCF Scientific Statement on the evaluation of syncope: from the American Heart Association Councils on Clinical Cardiology, Cardiovascular Nursing, Cardiovascular Disease in the Young, and Stroke, and the Quality of Care and Outcomes Research Interdisciplinary Working Group; and the American College of Cardiology Foundation: in collaboration with the Heart Rhythm Society: endorsed by the American Autonomic Society. Circulation. 2006 Jan 1/17/2006; 113(2): 316-27. PMID: 16418451, PII: 113/2/316, DOI: 10.1161/CIRCULATIONAHA.105.170274.
Strickberger SA, Benson DW, Biaggioni I, Callans DJ, Cohen MI, Ellenbogen KA, Epstein AE, Friedman P, Goldberger J, Heidenreich PA, Klein GJ, Knight BP, Morillo CA, Myerburg RJ, Sila CA, , , , . AHA/ACCF scientific statement on the evaluation of syncope: from the American Heart Association Councils on Clinical Cardiology, Cardiovascular Nursing, Cardiovascular Disease in the Young, and Stroke, and the Quality of Care and Outcomes Research Interdisciplinary Working Group; and the American College of Cardiology Foundation In Collaboration With the Heart Rhythm Society. J. Am. Coll. Cardiol. 2006 Jan 1/17/2006; 47(2): 473-84. PMID: 16412888, PII: S0735-1097(05)03044-5, DOI: 10.1016/j.jacc.2005.12.019.
Garland EM, Winker R, Williams SM, Jiang L, Stanton K, Byrne DW, Biaggioni I, Cascorbi I, Phillips JA, Harris PA, Rüdiger H, Robertson D. Endothelial NO synthase polymorphisms and postural tachycardia syndrome. Hypertension [print-electronic]. 2005 Nov; 46(5): 1103-10. PMID: 16203873, PII: 01.HYP.0000185462.08685.da, DOI: 10.1161/01.HYP.0000185462.08685.da, ISSN: 1524-4563.
Harris PA, Lane L, Biaggioni I. Clinical research subject recruitment: the Volunteer for Vanderbilt Research Program www.volunteer.mc.vanderbilt.edu. J Am Med Inform Assoc [print-electronic]. 2005 Nov; 12(6): 608-13. PMID: 16049231, PMCID: PMC1294031, PII: M1722, DOI: 10.1197/jamia.M1722, ISSN: 1067-5027.
Gamboa A, Abraham R, Diedrich A, Shibao C, Paranjape SY, Farley G, Biaggioni I. Role of adenosine and nitric oxide on the mechanisms of action of dipyridamole. Stroke [print-electronic]. 2005 Oct; 36(10): 2170-5. PMID: 16141426, PII: 01.STR.0000179044.37760.9d, DOI: 10.1161/01.STR.0000179044.37760.9d, ISSN: 1524-4628.
Winker R, Garland EM, Rüdiger HW, Diedrich A, Biaggioni I, Ponocny I, Cascorbi I, Robertson D. Influence of an insertion variant in the 5’UTR of the endothelin-1 gene on orthostatic intolerance. Am. J. Med. Sci. 2005 Oct; 330(4): 166-71. PMID: 16234608, PII: 00000441-200510000-00003, ISSN: 0002-9629.
Jacob G, Gamboa A, Diedrich A, Shibao C, Robertson D, Biaggioni I. Tyramine-induced vasodilation mediated by dopamine contamination: a paradox resolved. Hypertension [print-electronic]. 2005 Aug; 46(2): 355-9. PMID: 15967868, PII: 01.HYP.0000172353.62657.8b, DOI: 10.1161/01.HYP.0000172353.62657.8b, ISSN: 1524-4563.
Raj SR, Diedrich A, Biaggioni I. Can we diagnose, treat or even understand neurally mediated syncope?. Clin. Sci. 2005 Aug; 109(2): 161-3. PMID: 15842199, PII: CS20050122, DOI: 10.1042/CS20050122, ISSN: 0143-5221.
Raj SR, Black BK, Biaggioni I, Harris PA, Robertson D. Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome. Circulation [print-electronic]. 2005 May 5/31/2005; 111(21): 2734-40. PMID: 15911704, PII: CIRCULATIONAHA.104.497594, DOI: 10.1161/CIRCULATIONAHA.104.497594, ISSN: 1524-4539.
Jacob G, Raj SR, Ketch T, Pavlin B, Biaggioni I, Ertl AC, Robertson D. Postural pseudoanemia: posture-dependent change in hematocrit. Mayo Clin. Proc. 2005 May; 80(5): 611-4. PMID: 15887428, PII: S0025-6196(11)63092-9, DOI: 10.4065/80.5.611, ISSN: 0025-6196.
Moore ST, Diedrich A, Biaggioni I, Kaufmann H, Raphan T, Cohen B. Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance. Acta Astronaut. 2005 May; 56(9-12): 867-76. PMID: 15835033, ISSN: 0094-5765.
Raj SR, Biaggioni I, Yamhure PC, Black BK, Paranjape SY, Byrne DW, Robertson D. Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome. Circulation [print-electronic]. 2005 Apr 4/5/2005; 111(13): 1574-82. PMID: 15781744, PII: 01.CIR.0000160356.97313.5D, DOI: 10.1161/01.CIR.0000160356.97313.5D, ISSN: 1524-4539.
Shibao C, Gamboa A, Diedrich A, Biaggioni I. Management of hypertension in the setting of autonomic failure: a pathophysiological approach. Hypertension [print-electronic]. 2005 Apr; 45(4): 469-76. PMID: 15738343, PII: 01.HYP.0000158835.94916.0c, DOI: 10.1161/01.HYP.0000158835.94916.0c, ISSN: 1524-4563.
Shibao C, Arzubiaga C, Roberts LJ, Raj S, Black B, Harris P, Biaggioni I. Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension [print-electronic]. 2005 Mar; 45(3): 385-90. PMID: 15710782, PII: 01.HYP.0000158259.68614.40, DOI: 10.1161/01.HYP.0000158259.68614.40, ISSN: 1524-4563.
Garland EM, Vnencak-Jones CL, Biaggioni I, Davis TL, Montine TJ, Robertson D. Fragile X gene premutation in multiple system atrophy. J. Neurol. Sci. 2004 Dec 12/15/2004; 227(1): 115-8. PMID: 15546601, PII: S0022-510X(04)00320-X, DOI: 10.1016/j.jns.2004.08.013, ISSN: 0022-510X.
Feoktistov I, Ryzhov S, Zhong H, Goldstein AE, Matafonov A, Zeng D, Biaggioni I. Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype. Hypertension [print-electronic]. 2004 Nov; 44(5): 649-54. PMID: 15452028, PII: 01.HYP.0000144800.21037.a5, DOI: 10.1161/01.HYP.0000144800.21037.a5, ISSN: 1524-4563.
Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I, Feoktistov I. Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J. Immunol. 2004 Jun 6/15/2004; 172(12): 7726-33. PMID: 15187156, PII: 172/12/7726, ISSN: 0022-1767.
Diedrich A, Biaggioni I. Segmental orthostatic fluid shifts. Clin. Auton. Res. 2004 Jun; 14(3): 146-7. PMID: 15241642, DOI: 10.1007/s10286-004-0188-9, ISSN: 0959-9851.
Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Mol. Pharmacol. 2004 Jun; 65(6): 1462-74. PMID: 15155839, PII: 65/6/1462, DOI: 10.1124/mol.65.6.1462, ISSN: 0026-895X.
Schroeder C, Adams F, Boschmann M, Tank J, Haertter S, Diedrich A, Biaggioni I, Luft FC, Jordan J. Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2004 May; 286(5): R851-6. PMID: 14726430, PII: 00689.2003, DOI: 10.1152/ajpregu.00689.2003, ISSN: 0363-6119.
Jordan J, Shannon JR, Diedrich A, Black B, Robertson D, Biaggioni I. Water potentiates the pressor effect of ephedra alkaloids. Circulation [print-electronic]. 2004 Apr 4/20/2004; 109(15): 1823-5. PMID: 15066944, PII: 01.CIR.0000126283.99195.37, DOI: 10.1161/01.CIR.0000126283.99195.37, ISSN: 1524-4539.
Biaggioni I. Clinical and molecular pharmacologic characteristics of adenosine-induced vasodilation. Clin. Pharmacol. Ther. 2004 Mar; 75(3): 137-9. PMID: 15001963, PII: S0009923603003072, DOI: 10.1016/j.clpt.2003.09.017, ISSN: 0009-9236.
Goldstein DS, Holmes C, Jacob G, Costa F, Vincent S, Robertson D, Biaggioni I. Vasodilation during systemic tyramine administration response [letter]. Circulation. 2004 Jan 1/27/2004; 109(3): E17-8. PMID: 14744961, PII: 109/3/e17, DOI: 10.1161/01.CIR.0000113705.87604.A9, ISSN: 1524-4539.
Zhong H, Belardinelli L, Maa T, Feoktistov I, Biaggioni I, Zeng D. A(2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2004 Jan; 30(1): 118-25. PMID: 12855406, PII: 2003-0118OC, DOI: 10.1165/rcmb.2003-0118OC, ISSN: 1044-1549.
Kaufmann H, Biaggioni I. Autonomic failure in neurodegenerative disorders. Semin Neurol. 2003 Dec; 23(4): 351-63. PMID: 15088256, DOI: 10.1055/s-2004-817719, ISSN: 0271-8235.
Gamboa A, Ertl AC, Costa F, Farley G, Manier ML, Hachey DL, Diedrich A, Biaggioni I. Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humans. Circulation [print-electronic]. 2003 Nov 11/25/2003; 108(21): 2631-5. PMID: 14623808, PII: 01.CIR.0000101927.70100.41, DOI: 10.1161/01.CIR.0000101927.70100.41, ISSN: 1524-4539.
Biaggioni I. Autoimmune ganglionic blockade. A cause of autonomic failure. Focus on “Experimental Autoimmune Autonomic Neuropathy” [editorial]. J. Neurophysiol. 2003 Sep; 90(3): 1377-8. PMID: 12966172, PII: 90/3/1377, DOI: 10.1152/jn.00601.2003, ISSN: 0022-3077.
Diedrich A, Jordan J, Tank J, Shannon JR, Robertson R, Luft FC, Robertson D, Biaggioni I. The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade. J. Hypertens. 2003 Sep; 21(9): 1677-86. PMID: 12923400, DOI: 10.1097/01.hjh.0000084711.87421.07, ISSN: 0263-6352.
Cho S, Kim CH, Cubells JF, Zabetian CP, Hwang DY, Kim JW, Cohen BM, Biaggioni I, Robertson D, Kim KS. Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy. Am. J. Med. Genet. A. 2003 Jul 7/15/2003; 120A(2): 234-6. PMID: 12833405, DOI: 10.1002/ajmg.a.20194, ISSN: 1552-4825.
Jacob G, Costa F, Biaggioni I. Spectrum of autonomic cardiovascular neuropathy in diabetes. Diabetes Care. 2003 Jul; 26(7): 2174-80. PMID: 12832331, ISSN: 0149-5992.
Cuajungco MP, Ando Y, Axelrod FB, Biaggioni I, Goldstein DS, Guttmacher AE, Gwinn-Hardy K, Hahn MK, Hilz MJ, Jacob G, Jens J, Kennedy WR, Liggett SB, O’Connor DT, Peltzer SR, Robertson D, Rubin BY, Scudder Q, Smith LJ, Sonenshein GE, Svejstrup JQ, Xu Y, Slaugenhaupt SA. Hereditary dysautonomias: current knowledge and collaborations for the future. Clin. Auton. Res. 2003 Jun; 13(3): 180-95. PMID: 12822040, DOI: 10.1007/s10286-003-0098-2, ISSN: 0959-9851.
Jacob G, Costa F, Vincent S, Robertson D, Biaggioni I. Neurovascular dissociation with paradoxical forearm vasodilation during systemic tyramine administration. Circulation [print-electronic]. 2003 May 5/20/2003; 107(19): 2475-9. PMID: 12707242, PII: 01.CIR.0000065605.37863.C0, DOI: 10.1161/01.CIR.0000065605.37863.C0, ISSN: 1524-4539.
Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Circ. Res [print-electronic]. 2003 Mar 3/21/2003; 92(5): 485-92. PMID: 12600879, PII: 01.RES.0000061572.10929.2D, DOI: 10.1161/01.RES.0000061572.10929.2D, ISSN: 1524-4571.
Biaggioni I. Sympathetic control of the circulation in hypertension: lessons from autonomic disorders. Curr. Opin. Nephrol. Hypertens. 2003 Mar; 12(2): 175-80. PMID: 12589178, DOI: 10.1097/01.mnh.0000058796.51455.e4, ISSN: 1062-4821.
Biaggioni I. Adenosine and the exercise pressor reflex: a controversy resolved? [editorial]. Clin. Auton. Res. 2003 Feb; 13(1): 7-9. PMID: 12749329, ISSN: 0959-9851.
Biaggioni I. Research highlights from the literature. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2003 Feb; 13(1) Sect. 3,4.
Birkenfeld AL, Schroeder C, Boschmann M, Tank J, Franke G, Luft FC, Biaggioni I, Sharma AM, Jordan J. Paradoxical effect of sibutramine on autonomic cardiovascular regulation. Circulation. 2002 Nov 11/5/2002; 106(19): 2459-65. PMID: 12417543, ISSN: 1524-4539.
Boschmann M, Schroeder C, Christensen NJ, Tank J, Krupp G, Biaggioni I, Klaus S, Sharma AM, Luft FC, Jordan J. Norepinephrine transporter function and autonomic control of metabolism. J. Clin. Endocrinol. Metab. 2002 Nov; 87(11): 5130-7. PMID: 12414883, DOI: 10.1210/jc.2002-020533, ISSN: 0021-972X.
Bshesh K, Zhao B, Spight D, Biaggioni I, Feokistov I, Denenberg A, Wong HR, Shanley TP. The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. J. Leukoc. Biol. 2002 Nov; 72(5): 1027-36. PMID: 12429726, ISSN: 0741-5400.
Diedrich A, Jordan J, Shannon JR, Robertson D, Biaggioni I. Modulation of QT interval during autonomic nervous system blockade in humans. Circulation. 2002 Oct 10/22/2002; 106(17): 2238-43. PMID: 12390954, ISSN: 1524-4539.
Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF, Zuckerman JH, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC, Cooke WH, Robertson RM, Baisch FJ, Blomqvist CG, Eckberg DL, Robertson D, Biaggioni I. Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J. Physiol. (Lond.). 2002 Oct 10/15/2002; 544(Pt 2): 653-64. PMID: 12381834, PMCID: PMC2290607, PII: PHY_025098, ISSN: 0022-3751.
Garland EM, Hahn MK, Ketch TP, Keller NR, Kim CH, Kim KS, Biaggioni I, Shannon JR, Blakely RD, Robertson D. Genetic basis of clinical catecholamine disorders. Ann. N. Y. Acad. Sci. 2002 Oct; 971: 506-14. PMID: 12438171, ISSN: 0077-8923.
Parikh SM, Diedrich A, Biaggioni I, Robertson D. The nature of the autonomic dysfunction in multiple system atrophy. J. Neurol. Sci. 2002 Aug 8/15/2002; 200(1-2): 1-10. PMID: 12127669, PII: S0022510X02001260, ISSN: 0022-510X.
Ketch T, Biaggioni I, Robertson R, Robertson D. Four faces of baroreflex failure: hypertensive crisis, volatile hypertension, orthostatic tachycardia, and malignant vagotonia. Circulation. 2002 May 5/28/2002; 105(21): 2518-23. PMID: 12034659, ISSN: 1524-4539.
Biaggioni I, Robertson RM. Hypertension in orthostatic hypotension and autonomic dysfunction. Cardiol Clin. 2002 May; 20(2): 291-301, vii. PMID: 12119802, ISSN: 0733-8651.
Kaufmann H, Biaggioni I, Voustianiouk A, Diedrich A, Costa F, Clarke R, Gizzi M, Raphan T, Cohen B. Vestibular control of sympathetic activity. An otolith-sympathetic reflex in humans. Exp Brain Res [print-electronic]. 2002 Apr; 143(4): 463-9. PMID: 11914792, DOI: 10.1007/s00221-002-1002-3, ISSN: 0014-4819.
Shannon JR, Diedrich A, Biaggioni I, Tank J, Robertson RM, Robertson D, Jordan J. Water drinking as a treatment for orthostatic syndromes. Am. J. Med. 2002 Apr 4/1/2002; 112(5): 355-60. PMID: 11904109, PII: S0002934302010252, ISSN: 0002-9343.
Jordan J, Tank J, Shannon JR, Diedrich A, Lipp A, Schröder C, Arnold G, Sharma AM, Biaggioni I, Robertson D, Luft FC. Baroreflex buffering and susceptibility to vasoactive drugs. Circulation. 2002 Mar 3/26/2002; 105(12): 1459-64. PMID: 11914255, ISSN: 1524-4539.
Feoktistov I, Goldstein AE, Ryzhov S, Zeng D, Belardinelli L, Voyno-Yasenetskaya T, Biaggioni I. Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation. Circ. Res. 2002 Mar 3/22/2002; 90(5): 531-8. PMID: 11909816, ISSN: 1524-4571.
Jordan J, Biaggioni I. Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotension. J Clin Hypertens (Greenwich). 2002 Mar; 4(2): 139-45. PMID: 11927799, ISSN: 1524-6175.
Kim CH, Zabetian CP, Cubells JF, Cho S, Biaggioni I, Cohen BM, Robertson D, Kim KS. Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency. Am. J. Med. Genet. 2002 Mar 3/1/2002; 108(2): 140-7. PMID: 11857564, PII: 10.1002/ajmg.10196, ISSN: 0148-7299.
Biaggioni I, Davis SN. Caffeine: a cause of insulin resistance? [editorial]. Diabetes Care. 2002 Feb; 25(2): 399-400. PMID: 11815519, ISSN: 0149-5992.
Schroeder C, Tank J, Boschmann M, Diedrich A, Sharma AM, Biaggioni I, Luft FC, Jordan J. Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance. Circulation. 2002 Jan 1/22/2002; 105(3): 347-53. PMID: 11804991, ISSN: 1524-4539.
Cox JF, Tahvanainen KU, Kuusela TA, Levine BD, Cooke WH, Mano T, Iwase S, Saito M, Sugiyama Y, Ertl AC, Biaggioni I, Diedrich A, Robertson RM, Zuckerman JH, Lane LD, Ray CA, White RJ, Pawelczyk JA, Buckey JC, Baisch FJ, Blomqvist CG, Robertson D, Eckberg DL. Influence of microgravity on astronauts’ sympathetic and vagal responses to Valsalva’s manoeuvre. J. Physiol. (Lond.). 2002 Jan 1/1/2002; 538(Pt 1): 309-20. PMID: 11773338, PMCID: PMC2290008, PII: PHY_12574, ISSN: 0022-3751.
Ertl AC, Diedrich A, Biaggioni I, Levine BD, Robertson RM, Cox JF, Zuckerman JH, Pawelczyk JA, Ray CA, Buckey JC, Lane LD, Shiavi R, Gaffney FA, Costa F, Holt C, Blomqvist CG, Eckberg DL, Baisch FJ, Robertson D. Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. J. Physiol. (Lond.). 2002 Jan 1/1/2002; 538(Pt 1): 321-9. PMID: 11773339, PMCID: PMC2290013, PII: PHY_12576, ISSN: 0022-3751.
Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC, Cooke WH, Baisch FJ, Eckberg DL, Blomqvist CG. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J. Physiol. (Lond.). 2002 Jan 1/1/2002; 538(Pt 1): 331-40. PMID: 11773340, PMCID: PMC2290017, PII: PHY_12575, ISSN: 0022-3751.
Robertson D, Jordan J, Jacob G, Ketch T, Shannon JR, Biaggioni I. Ageing and water homeostasis. Novartis Found. Symp. 2002; 242: 265-75; discussion 275. PMID: 11855693, ISSN: 1528-2511.
Mino RP, Spoerri PE, Caballero S, Player D, Belardinelli L, Biaggioni I, Grant MB. Adenosine receptor antagonists and retinal neovascularization in vivo. Invest. Ophthalmol. Vis. Sci. 2001 Dec; 42(13): 3320-4. PMID: 11726639, ISSN: 0146-0404.
Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I. Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochem. Pharmacol. 2001 Nov 11/1/2001; 62(9): 1163-73. PMID: 11705449, PII: S0006295201007651, ISSN: 0006-2952.
Grant MB, Davis MI, Caballero S, Feoktistov I, Biaggioni I, Belardinelli L. Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest. Ophthalmol. Vis. Sci. 2001 Aug; 42(9): 2068-73. PMID: 11481274, ISSN: 0146-0404.
Robertson D, Shannon JR, Jordan J, Davis TL, Diedrich A, Jacob G, Garland E, Tellioglu T, Biaggioni I. Multiple system atrophy: new developments in pathophysiology and therapy. Parkinsonism Relat. Disord. 2001 Jul; 7(3): 257-60. PMID: 11331196, PII: S1353-8020(00)00067-5, ISSN: 1873-5126.
Biaggioni I. The role of adenosine in neurogenic syncope: much ado about something? [editorial]. Clin. Auton. Res. 2001 Jun; 11(3): 143-4. PMID: 11605818, ISSN: 0959-9851.
Robertson D, Flattem N, Tellioglu T, Carson R, Garland E, Shannon JR, Jordan J, Jacob G, Blakely RD, Biaggioni I. Familial orthostatic tachycardia due to norepinephrine transporter deficiency. Ann. N. Y. Acad. Sci. 2001 Jun; 940: 527-43. PMID: 11458707, ISSN: 0077-8923.
Costa F, Christensen NJ, Farley G, Biaggioni I. NO modulates norepinephrine release in human skeletal muscle: implications for neural preconditioning. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001 May; 280(5): R1494-8. PMID: 11294774, ISSN: 0363-6119.
Garland EM, Biaggioni I. Genetic polymorphisms of adrenergic receptors. Clin. Auton. Res. 2001 Apr; 11(2): 67-78. PMID: 11570606, ISSN: 0959-9851.
Costa F, Diedrich A, Johnson B, Sulur P, Farley G, Biaggioni I. Adenosine, a metabolic trigger of the exercise pressor reflex in humans. Hypertension. 2001 Mar; 37(3): 917-22. PMID: 11244018, ISSN: 1524-4563.
Feoktistov I, Goldstein AE, Biaggioni I. Cyclic AMP and protein kinase A stimulate Cdc42: role of A(2) adenosine receptors in human mast cells. Mol. Pharmacol. 2000 Nov; 58(5): 903-10. PMID: 11040036, ISSN: 0026-895X.
Jacob G, Costa F, Shannon JR, Robertson RM, Wathen M, Stein M, Biaggioni I, Ertl A, Black B, Robertson D. The neuropathic postural tachycardia syndrome. N. Engl. J. Med. 2000 Oct 10/5/2000; 343(14): 1008-14. PMID: 11018167, DOI: 10.1056/NEJM200010053431404, ISSN: 0028-4793.
Ertl AC, Diedrich A, Biaggioni I. Baroreflex dysfunction induced by microgravity: potential relevance to postflight orthostatic intolerance. Clin. Auton. Res. 2000 Oct; 10(5): 269-77. PMID: 11198482, ISSN: 0959-9851.
Duda JE, Giasson BI, Gur TL, Montine TJ, Robertson D, Biaggioni I, Hurtig HI, Stern MB, Gollomp SM, Grossman M, Lee VM, Trojanowski JQ. Immunohistochemical and biochemical studies demonstrate a distinct profile of alpha-synuclein permutations in multiple system atrophy. J. Neuropathol. Exp. Neurol. 2000 Sep; 59(9): 830-41. PMID: 11005264, ISSN: 0022-3069.
Jordan J, Shannon JR, Diedrich A, Black B, Costa F, Robertson D, Biaggioni I. Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans. Hypertension. 2000 Sep; 36(3): 383-8. PMID: 10988269, ISSN: 1524-4563.
Tellioglu T, Oates JA, Biaggioni I. Munchausen’s syndrome presenting as baroreflex failure. N. Engl. J. Med. 2000 Aug 8/24/2000; 343(8): 581. PMID: 10979787, DOI: 10.1056/NEJM200008243430814, ISSN: 0028-4793.
Shannon JR, Jordan J, Diedrich A, Pohar B, Black BK, Robertson D, Biaggioni I. Sympathetically mediated hypertension in autonomic failure. Circulation. 2000 Jun 6/13/2000; 101(23): 2710-5. PMID: 10851208, ISSN: 1524-4539.
Costa F, Heusinkveld J, Ballog R, Davis S, Biaggioni I. Estimation of skeletal muscle interstitial adenosine during forearm dynamic exercise in humans. Hypertension. 2000 May; 35(5): 1124-8. PMID: 10818075, ISSN: 1524-4563.
Ali YS, Daamen N, Jacob G, Jordan J, Shannon JR, Biaggioni I, Robertson D. Orthostatic intolerance: a disorder of young women. Obstet Gynecol Surv. 2000 Apr; 55(4): 251-9. PMID: 10758621, ISSN: 0029-7828.
Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D. Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N. Engl. J. Med. 2000 Feb 2/24/2000; 342(8): 541-9. PMID: 10684912, DOI: 10.1056/NEJM200002243420803, ISSN: 0028-4793.
Jordan J, Shannon JR, Black BK, Ali Y, Farley M, Costa F, Diedrich A, Robertson RM, Biaggioni I, Robertson D. The pressor response to water drinking in humans : a sympathetic reflex?. Circulation. 2000 Feb 2/8/2000; 101(5): 504-9. PMID: 10662747, ISSN: 1524-4539.
Jacob G, Costa F, Shannon J, Robertson D, Biaggioni I. Dissociation between neural and vascular responses to sympathetic stimulation : contribution of local adrenergic receptor function. Hypertension. 2000 Jan; 35(1 Pt 1): 76-81. PMID: 10642278, ISSN: 0194-911X.
Robertson D, Shannon JR, Biaggioni I, Ertl AC, Diedrich A, Carson R, Furlan R, Jacob G, Jordan J, . Orthostatic intolerance and the postural tachycardia syndrome: genetic and environment pathophysiologies. Neurolab Autonomic Team. Pflugers Arch. 2000; 441(2-3 Suppl): R48-51. PMID: 11200979, ISSN: 0031-6768.
Grant MB, Tarnuzzer RW, Caballero S, Ozeck MJ, Davis MI, Spoerri PE, Feoktistov I, Biaggioni I, Shryock JC, Belardinelli L. Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells. Circ. Res. 1999 Oct 10/15/1999; 85(8): 699-706. PMID: 10521243, ISSN: 1524-4571.
Robertson D, Biaggioni I, Ertl AC, Robertson RM, Diedrich A, Blakely RD, Flattem N, Shannon JR. Orthostatic intolerance: emerging genetic and environmental etiologies. J Gravit Physiol. 1999 Jul; 6(1): P51-4. PMID: 11543025, ISSN: 1077-9248.
Costa F, Sulur P, Angel M, Cavalcante J, Haile V, Christman B, Biaggioni I. Intravascular source of adenosine during forearm ischemia in humans: implications for reactive hyperemia. Hypertension. 1999 Jun; 33(6): 1453-7. PMID: 10373232, ISSN: 0194-911X.
Jacob G, Shannon JR, Costa F, Furlan R, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D. Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance. Circulation. 1999 Apr 4/6/1999; 99(13): 1706-12. PMID: 10190880, ISSN: 0009-7322.
Feoktistov I, Goldstein AE, Biaggioni I. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Mol. Pharmacol. 1999 Apr; 55(4): 726-34. PMID: 10101031, ISSN: 0026-895X.
Montine TJ, Beal MF, Robertson D, Cudkowicz ME, Biaggioni I, O’Donnell H, Zackert WE, Roberts LJ, Morrow JD. Cerebrospinal fluid F2-isoprostanes are elevated in Huntington’s disease. Neurology. 1999 Mar 3/23/1999; 52(5): 1104-5. PMID: 10102447, ISSN: 0028-3878.
Jordan J, Shannon JR, Grogan E, Biaggioni I, Robertson D. A potent pressor response elicited by drinking water [letter]. Lancet. 1999 Feb 2/27/1999; 353(9154): 723. PMID: 10073520, PII: S0140-6736(99)99015-3, DOI: 10.1016/S0140-6736(99)99015-3, ISSN: 0140-6736.
Jacob G, Biaggioni I. Idiopathic orthostatic intolerance and postural tachycardia syndromes. Am. J. Med. Sci. 1999 Feb; 317(2): 88-101. PMID: 10037112, ISSN: 0002-9629.
Jordan J, Shannon JR, Pohar B, Paranjape SY, Robertson D, Robertson RM, Biaggioni I. Contrasting effects of vasodilators on blood pressure and sodium balance in the hypertension of autonomic failure. J. Am. Soc. Nephrol. 1999 Jan; 10(1): 35-42. PMID: 9890307, ISSN: 1046-6673.
Choy AM, Lang CC, Roden DM, Robertson D, Wood AJ, Robertson RM, Biaggioni I. Abnormalities of the QT interval in primary disorders of autonomic failure. Am. Heart J. 1998 Oct; 136(4 Pt 1): 664-71. PMID: 9778070, PII: S0002870398000726, ISSN: 0002-8703.
Jordan J, Shannon JR, Biaggioni I, Norman R, Black BK, Robertson D. Contrasting actions of pressor agents in severe autonomic failure. Am. J. Med. 1998 Aug; 105(2): 116-24. PMID: 9727818, PII: S0002934398001934, ISSN: 0002-9343.
Costa F, Biaggioni I. Role of nitric oxide in adenosine-induced vasodilation in humans. Hypertension. 1998 May; 31(5): 1061-4. PMID: 9576114, ISSN: 0194-911X.
Feoktistov I, Polosa R, Holgate ST, Biaggioni I. Adenosine A2B receptors: a novel therapeutic target in asthma?. Trends Pharmacol. Sci. 1998 Apr; 19(4): 148-53. PMID: 9612090, PII: S0165-6147(98)01179-1, ISSN: 0165-6147.
Feoktistov I, Biaggioni I. Pharmacological characterization of adenosine A2B receptors: studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes. Biochem. Pharmacol. 1998 Mar 3/1/1998; 55(5): 627-33. PMID: 9515573, PII: S0006-2952(97)00512-1, ISSN: 0006-2952.
Jacob G, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D. Relation of blood volume and blood pressure in orthostatic intolerance. Am. J. Med. Sci. 1998 Feb; 315(2): 95-100. PMID: 9472908, ISSN: 0002-9629.
Biaggioni I, Costa F, Kaufmann H. Vestibular influences on autonomic cardiovascular control in humans. J Vestib Res. 1998 Jan; 8(1): 35-41. PMID: 9416587, PII: S0957427197000335, ISSN: 0957-4271.
Feoktistov I, Biaggioni I. Adenosine A2B receptors. Pharmacol. Rev. 1997 Dec; 49(4): 381-402. PMID: 9443164, ISSN: 0031-6997.
Jordan J, Shannon JR, Black BK, Costa F, Ertl AC, Furlan R, Biaggioni I, Robertson D. Malignant vagotonia due to selective baroreflex failure. Hypertension. 1997 Nov; 30(5): 1072-7. PMID: 9369258, ISSN: 0194-911X.
Shannon J, Jordan J, Costa F, Robertson RM, Biaggioni I. The hypertension of autonomic failure and its treatment. Hypertension. 1997 Nov; 30(5): 1062-7. PMID: 9369256, ISSN: 0194-911X.
Feoktistov I, Breyer RM, Biaggioni I. Prostanoid receptor with a novel pharmacological profile in human erythroleukemia cells. Biochem. Pharmacol. 1997 Oct 10/15/1997; 54(8): 917-26. PMID: 9354592, PII: S0006-2952(97)00288-8, ISSN: 0006-2952.
Maller A, Hyland K, Milstien S, Biaggioni I, Butler IJ. Aromatic L-amino acid decarboxylase deficiency: clinical features, diagnosis, and treatment of a second family. J. Child Neurol. 1997 Sep; 12(6): 349-54. PMID: 9309516, ISSN: 0883-0738.
Jacob G, Robertson D, Mosqueda-Garcia R, Ertl AC, Robertson RM, Biaggioni I. Hypovolemia in syncope and orthostatic intolerance role of the renin-angiotensin system. Am. J. Med. 1997 Aug; 103(2): 128-33. PMID: 9274896, PII: S0002934397001332, ISSN: 0002-9343.
Jacob G, Shannon JR, Black B, Biaggioni I, Mosqueda-Garcia R, Robertson RM, Robertson D. Effects of volume loading and pressor agents in idiopathic orthostatic tachycardia. Circulation. 1997 Jul 7/15/1997; 96(2): 575-80. PMID: 9244228, ISSN: 0009-7322.
Robertson D, Jacob G, Ertl A, Shannon J, Mosqueda-Garcia R, Robertson RM, Biaggioni I. Clinical models of cardiovascular regulation after weightlessness. Med Sci Sports Exerc. 1996 Oct; 28(10 Suppl): S80-4. PMID: 8897409, ISSN: 0195-9131.
Feoktistov I, Biaggioni I. Role of adenosine in asthma. Drug Dev. Res. 1996; 39: 333-6. PMID: 11542498, DOI: 10.1002/(SICI)1098-2299(199611/12)39:3/4<333::AID-DDR14>3.0.CO;2-2, ISSN: 0272-4391.
Costa F, Lavin P, Robertson D, Biaggioni I. Effect of neurovestibular stimulation on autonomic regulation. Clin. Auton. Res. 1995 Oct; 5(5): 289-93. PMID: 8563462, ISSN: 0959-9851.
Feoktistov I, Biaggioni I. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J. Clin. Invest. 1995 Oct; 96(4): 1979-86. PMID: 7560091, PMCID: PMC185836, DOI: 10.1172/JCI118245, ISSN: 0021-9738.
Biaggioni I, Robertson D, Krantz S, Jones M, Haile V. The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann. Intern. Med. 1994 Aug 8/1/1994; 121(3): 181-6. PMID: 8017744, ISSN: 0003-4819.
Costa F, Biaggioni I. Microneurographic evidence of sudden sympathetic withdrawal in carotid sinus syncope; treatment with ergotamine. Chest. 1994 Aug; 106(2): 617-20. PMID: 7774353, ISSN: 0012-3692.
Robertson D, Krantz SB, Biaggioni I. The anemia of microgravity and recumbency: role of sympathetic neural control of erythropoietin production. Acta Astronaut. 1994 Jul; 33: 137-41. PMID: 11539513, ISSN: 0094-5765.
Feoktistov I, Murray JJ, Biaggioni I. Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells. Mol. Pharmacol. 1994 Jun; 45(6): 1160-7. PMID: 8022409, ISSN: 0026-895X.
Biaggioni I, Robertson RM, Robertson D. Manipulation of norepinephrine metabolism with yohimbine in the treatment of autonomic failure. J Clin Pharmacol. 1994 May; 34(5): 418-23. PMID: 8089252, ISSN: 0091-2700.
Biaggioni I, Whetsell WO, Jobe J, Nadeau JH. Baroreflex failure in a patient with central nervous system lesions involving the nucleus tractus solitarii. Hypertension. 1994 Apr; 23(4): 491-5. PMID: 8144218, ISSN: 0194-911X.
Costa F, Biaggioni I. Role of adenosine in the sympathetic activation produced by isometric exercise in humans. J. Clin. Invest. 1994 Apr; 93(4): 1654-60. PMID: 8163667, PMCID: PMC294207, DOI: 10.1172/JCI117147, ISSN: 0021-9738.
O’Connor DT, Cervenka JH, Stone RA, Levine GL, Parmer RJ, Franco-Bourland RE, Madrazo I, Langlais PJ, Robertson D, Biaggioni I. Dopamine beta-hydroxylase immunoreactivity in human cerebrospinal fluid: properties, relationship to central noradrenergic neuronal activity and variation in Parkinson’s disease and congenital dopamine beta-hydroxylase deficiency. Clin. Sci. 1994 Feb; 86(2): 149-58. PMID: 8143425, ISSN: 0143-5221.
Costa F, Biaggioni I. Adenosine activates afferent fibers in the forearm, producing sympathetic stimulation in humans. J. Pharmacol. Exp. Ther. 1993 Dec; 267(3): 1369-74. PMID: 8263799, ISSN: 0022-3565.
Robertson D, Hollister AS, Biaggioni I, Netterville JL, Mosqueda-Garcia R, Robertson RM. The diagnosis and treatment of baroreflex failure. N. Engl. J. Med. 1993 Nov 11/11/1993; 329(20): 1449-55. PMID: 8413455, DOI: 10.1056/NEJM199311113292003, ISSN: 0028-4793.
Paul S, Kurunwune B, Biaggioni I. Caffeine withdrawal: apparent heterologous sensitization to adenosine and prostacyclin actions in human platelets. J. Pharmacol. Exp. Ther. 1993 Nov; 267(2): 838-43. PMID: 8246157, ISSN: 0022-3565.
Feoktistov I, Biaggioni I. Characterization of adenosine receptors in human erythroleukemia cells and platelets: further evidence for heterogeneity of adenosine A2 receptor subtypes. Mol. Pharmacol. 1993 Jun; 43(6): 909-14. PMID: 8391117, ISSN: 0026-895X.
Biaggioni I, Garcia F, Inagami T, Haile V. Hyporeninemic normoaldosteronism in severe autonomic failure. J. Clin. Endocrinol. Metab. 1993 Mar; 76(3): 580-6. PMID: 7680352, DOI: 10.1210/jcem.76.3.7680352, ISSN: 0021-972X.
Robertson D, Gaffney FA, Biaggioni I. Orthostatic hypotension in earthlings and space travelers [editorial]. West. J. Med. 1992 Dec; 157(6): 679. PMID: 1475962, PMCID: PMC1022114, ISSN: 0093-0415.
Biaggioni I. Contrasting excitatory and inhibitory effects of adenosine in blood pressure regulation. Hypertension. 1992 Oct; 20(4): 457-65. PMID: 1398881, ISSN: 0194-911X.
Robertson D, Biaggioni I, Mosqueda-Garcia R, Robertson RM. Orthostatic hypotension of prolonged weightlessness: clinical models. Acta Astronaut. 1992 Jul; 27: 97-101. PMID: 11537606, ISSN: 0094-5765.
Feoktistov IA, Paul S, Hollister AS, Robertson D, Biaggioni I. Role of cyclic AMP in adenosine inhibition of intracellular calcium rise in human platelets. Comparison of adenosine effects on thrombin- and epinephrine-induced platelet stimulation. Am. J. Hypertens. 1992 Jun; 5(6 Pt 2): 147S-153S. PMID: 1321639, ISSN: 0895-7061.
Robertson D, Mosqueda-Garcia R, Robertson RM, Biaggioni I. Chronic hypotension. In the shadow of hypertension. Am. J. Hypertens. 1992 Jun; 5(6 Pt 2): 200S-205S. PMID: 1632940, ISSN: 0895-7061.
Robertson D, Biaggioni I. Orthostatic hypotension. More heterogeneity [editorial]. Arch. Intern. Med. 1992 May; 152(5): 919. PMID: 1580714, ISSN: 0003-9926.
Robertson RM, Biaggioni I, Mosqueda-Garcia R, Robertson D. Autonomic dysfunction: diagnosis guided by therapy. Trans. Am. Clin. Climatol. Assoc. 1992; 103: 228-37. PMID: 1413383, PMCID: PMC2376695, ISSN: 0065-7778.
Biaggioni I, Paul S, Puckett A, Arzubiaga C. Caffeine and theophylline as adenosine receptor antagonists in humans. J. Pharmacol. Exp. Ther. 1991 Aug; 258(2): 588-93. PMID: 1865359, ISSN: 0022-3565.
Llanos A, Cieza J, Bernardo J, Echevarria J, Biaggioni I, Sabra R, Branch RA. Effect of salt supplementation on amphotericin B nephrotoxicity. Kidney Int. 1991 Aug; 40(2): 302-8. PMID: 1942779, ISSN: 0085-2538.
Robertson D, Haile V, Perry SE, Robertson RM, Phillips JA, Biaggioni I. Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul; 18(1): 1-8. PMID: 1677640, ISSN: 0194-911X.
Biaggioni I, Killian TJ, Mosqueda-Garcia R, Robertson RM, Robertson D. Adenosine increases sympathetic nerve traffic in humans. Circulation. 1991 May; 83(5): 1668-75. PMID: 2022024, ISSN: 0009-7322.
Onrot J, Bernard GR, Biaggioni I, Hollister AS, Robertson D. Direct vasodilator effect of hyperventilation-induced hypocarbia in autonomic failure patients. Am. J. Med. Sci. 1991 May; 301(5): 305-9. PMID: 1902350, ISSN: 0002-9629.
King LS, Fukushima M, Banerjee M, Kang KH, Newman JH, Biaggioni I. Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. Circ. Res. 1991 Feb; 68(2): 352-8. PMID: 1825033, ISSN: 0009-7330.
Arzubiaga C, Morrow J, Roberts LJ, Biaggioni I. Neuropeptide Y, a putative cotransmitter in noradrenergic neurons, induces mast cell degranulation but not prostaglandin D2 release. J. Allergy Clin. Immunol. 1991 Jan; 87(1 Pt 1): 88-93. PMID: 1825102, ISSN: 0091-6749.
Mosqueda-Garcia R, Tseng CJ, Biaggioni I, Robertson RM, Robertson D. Effects of caffeine on baroreflex activity in humans. Clin. Pharmacol. Ther. 1990 Nov; 48(5): 568-74. PMID: 2225715, PII: 0009-9236(90)90099-Q, ISSN: 0009-9236.
Paul S, Feoktistov I, Hollister AS, Robertson D, Biaggioni I. Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: evidence that both effects are coupled to adenylate cyclase. Mol. Pharmacol. 1990 Jun; 37(6): 870-5. PMID: 2359405, ISSN: 0026-895X.
Biaggioni I, Goldstein DS, Atkinson T, Robertson D. Dopamine-beta-hydroxylase deficiency in humans. Neurology. 1990 Feb; 40(2): 370-3. PMID: 2300263, ISSN: 0028-3878.
Biaggioni I, Zygmunt D, Haile V, Robertson D. Pressor effect of inhaled ergotamine in orthostatic hypotension. Am. J. Cardiol. 1990 Jan 1/1/1990; 65(1): 89-92. PMID: 2104735, PII: 0002-9149(90)90031-U, ISSN: 0002-9149.
Rea RF, Biaggioni I, Robertson RM, Haile V, Robertson D. Reflex control of sympathetic nerve activity in dopamine beta-hydroxylase deficiency. Hypertension. 1990 Jan; 15(1): 107-12. PMID: 2295511, ISSN: 0194-911X.
Biaggioni I, King LS, Enayat N, Robertson D, Newman JH. Adenosine produces pulmonary vasoconstriction in sheep. Evidence for thromboxane A2/prostaglandin endoperoxide-receptor activation. Circ. Res. 1989 Dec; 65(6): 1516-25. PMID: 2582587, ISSN: 0009-7330.
Goldstein DS, Polinsky RJ, Garty M, Robertson D, Brown RT, Biaggioni I, Stull R, Kopin IJ. Patterns of plasma levels of catechols in neurogenic orthostatic hypotension. Ann. Neurol. 1989 Oct; 26(4): 558-63. PMID: 2510587, DOI: 10.1002/ana.410260410, ISSN: 0364-5134.
Paul S, Jackson EK, Robertson D, Branch RA, Biaggioni I. Caffeine potentiates the renin response to furosemide in rats. Evidence for a regulatory role of endogenous adenosine. J. Pharmacol. Exp. Ther. 1989 Oct; 251(1): 183-7. PMID: 2677316, ISSN: 0022-3565.
Biaggioni I, Paul S, Robertson D. A simple liquid-chromatographic method applied to determine caffeine in plasma and tissues. Clin. Chem. 1988 Nov; 34(11): 2345-8. PMID: 3180432, ISSN: 0009-9147.
Ohnishi A, Li P, Branch RA, Biaggioni IO, Jackson EK. Adenosine in renin-dependent renovascular hypertension. Hypertension. 1988 Aug; 12(2): 152-61. PMID: 3044993, ISSN: 0194-911X.
Paul S, Zygmunt D, Haile V, Robertson D, Biaggioni I. Chronic orthostatic hypotension. Compr Ther. 1988 Aug; 14(8): 58-65. PMID: 3048866, ISSN: 0098-8243.
Tseng CJ, Biaggioni I, Appalsamy M, Robertson D. Purinergic receptors in the brainstem mediate hypotension and bradycardia. Hypertension. 1988 Feb; 11(2): 191-7. PMID: 3277913, ISSN: 0194-911X.
Biaggioni I, Olafsson B, Robertson RM, Hollister AS, Robertson D. Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation. Circ. Res. 1987 Dec; 61(6): 779-86. PMID: 3677336, ISSN: 0009-7330.
Biaggioni I, Hollister AS, Robertson D. Dopamine in dopamine-beta-hydroxylase deficiency [letter]. N. Engl. J. Med. 1987 Nov 11/26/1987; 317(22): 1415-6. PMID: 3683474, DOI: 10.1056/NEJM198711263172212, ISSN: 0028-4793.
Biaggioni I, Robertson D. Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency. Lancet. 1987 Nov 11/21/1987; 2(8569): 1170-2. PMID: 2890806, PII: S0140-6736(87)91317-1, ISSN: 0140-6736.
Onrot J, Wiley RG, Fogo A, Biaggioni I, Robertson D, Hollister AS. Neck tumour with syncope due to paroxysmal sympathetic withdrawal. J. Neurol. Neurosurg. Psychiatr. 1987 Aug; 50(8): 1063-6. PMID: 3655815, PMCID: PMC1032240, ISSN: 0022-3050.
Biaggioni I, Onrot J, Stewart CK, Robertson D. The potent pressor effect of phenylpropanolamine in patients with autonomic impairment. JAMA. 1987 Jul 7/10/1987; 258(2): 236-9. PMID: 3599310, ISSN: 0098-7484.
Onrot J, Goldberg MR, Biaggioni I, Wiley RG, Hollister AS, Robertson D. Oral yohimbine in human autonomic failure. Neurology. 1987 Feb; 37(2): 215-20. PMID: 3808301, ISSN: 0028-3878.
Onrot J, Goldberg MR, Biaggioni I, Hollister AS, Kincaid D, Robertson D. Postjunctional vascular smooth muscle alpha-2 adrenoreceptors in human autonomic failure. Clin Invest Med. 1987 Jan; 10(1): 26-31. PMID: 3028681, ISSN: 0147-958X.
Biaggioni I, Onrot J, Hollister AS, Robertson D. Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole. Life Sci. 1986 Dec 12/8/1986; 39(23): 2229-36. PMID: 3537603, ISSN: 0024-3205.
Onrot J, Shaheen O, Biaggioni I, Goldberg MR, Feely J, Wilkinson GR, Hollister AS, Robertson D. Reduction of liver plasma flow by caffeine and theophylline. Clin. Pharmacol. Ther. 1986 Nov; 40(5): 506-10. PMID: 3769381, PII: 0009-9236(86)90062-7, ISSN: 0009-9236.
Ohnishi A, Branch RA, Jackson K, Hamilton R, Biaggioni I, Deray G, Jackson EK. Chronic caffeine administration exacerbates renovascular, but not genetic, hypertension in rats. J. Clin. Invest. 1986 Oct; 78(4): 1045-50. PMID: 3020089, PMCID: PMC423756, DOI: 10.1172/JCI112659, ISSN: 0021-9738.
Hollister AS, Tanaka I, Imada T, Onrot J, Biaggioni I, Robertson D, Inagami T. Sodium loading and posture modulate human atrial natriuretic factor plasma levels. Hypertension. 1986 Jun; 8(6 Pt 2): II106-11. PMID: 2941366, ISSN: 0194-911X.
Ohnishi A, Biaggioni I, Deray G, Branch RA, Jackson EK. Hemodynamic effects of adenosine in conscious hypertensive and normotensive rats. Hypertension. 1986 May; 8(5): 391-8. PMID: 3699881, ISSN: 0194-911X.
Onrot J, Goldberg MR, Hollister AS, Biaggioni I, Robertson RM, Robertson D. Management of chronic orthostatic hypotension. Am. J. Med. 1986 Mar; 80(3): 454-64. PMID: 2937292, PII: 0002-9343(86)90720-5, ISSN: 0002-9343.
Robertson D, Onrot J, Biaggioni I, Hollister A. [Alpha 2-adrenoreceptor regulation in the human body]. Kardiologiia. 1986 Jan; 26(1): 15-20. PMID: 3005749, ISSN: 0022-9040.
Onrot J, Goldberg MR, Biaggioni I, Hollister AS, Kingaid D, Robertson D. Hemodynamic and humoral effects of caffeine in autonomic failure. Therapeutic implications for postprandial hypotension. N. Engl. J. Med. 1985 Aug 8/29/1985; 313(9): 549-54. PMID: 3894971, DOI: 10.1056/NEJM198508293130905, ISSN: 0028-4793.
Arzubiaga C, Huayanay J, Biaggioni I. [Epidemiological study of American cutaneous leishmaniasis in Maypuco, Peru]. Bol Oficina Sanit Panam. 1984 May; 96(5): 417-24. PMID: 6234001, ISSN: 0030-0632.
Arzubiaga C, Huayanay J, Biaggioni I. An epidemiologic study of American cutaneous leishmaniasis in Maipuco, Peru. Bull Pan Am Health Organ. 1984; 18(1): 19-25. PMID: 6733343, ISSN: 0085-4638.