Relocation in the form of a miscellaneous allowance will be provided for eligible candidates.

The intern will focus on commercially available physiologically relevant 3D liver model systems to evaluate their application in improving in vitro to in vivo correlation (IVIVC) for small molecules pharmacokinetics, when transporters play an important role in the their elimination and disposition. The work will provide insight into our understanding of the value and limitations of available 3D liver models to potentially improve IVIVC in situations where metabolism and transporters work in concert to determine drug clearance . Additionally, the intern will have the opportunity to learn a variety of in vitro tools used to study drug interaction with transporters to support drug discovery and development. Depending on the progress made during this project, this work may lead to a peer reviewed publication.

Basic Qualifications

• Amgen requires that all individuals applying for a grad internship or a co-op assignment at Amgen must meet the following criteria:
• 18 years or older
• Graduated with a Bachelor’s degree from an accredited college or university with a 3.0 minimum GPA or equivalent
• Completion as a first year graduate student before internship starts and currently enrolled in a PhD for a PhD internship from an accredited college or university
• Enrolled in an accredited college or university following the potential internship or co-op assignment
• Must not be employed at the time the internship starts

Preferred Qualifications

• Candidate pursuing a PhD degree in Pharmaceutical Sciences or related fields
• Hands on experience with primary hepatocytes culture, any relevant 2D and 3D liver models and/or in vitro transporter assays is desired but not necessary
• Experience with LC-MS analysis a plus
• Ability to critically think, independent lab work, strong attention to details
• Excellent written and oral communication skills

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Only candidates who apply via http://careers.amgen.com/ will be considered. Please search for Keyword 68775.