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Job Opportunity: Senior Scientist, Gene Therapy Purification Process Development, Pfizer, Chesterfield, MO

Posted by on Tuesday, July 28, 2020 in Job Opportunities .


A Senior Scientist (level R4) position is available in the Gene Therapy Purification Process Development group, Bioprocess R&D. The successful applicant will have experience in laboratory research, and a desire to continue in a laboratory-focused role. This position will join a larger team of scientists across multiple sites focused on developing and optimizing recovery and purification processes for gene therapy vectors for early- and late-phase clinical trials. The Senior Scientist will be responsible for working with fellow scientists on technology development initiatives as well as developing robust, efficient, scalable strategies for improving process performance.


Responsibilities will include studies at wide range of scales, from high throughput/small scale to pilot/manufacturing scale. Based on the analyses of these studies, this position will be expected to develop and test new hypotheses to improve the fundamental understanding of recovery and purification processes. This position will be expected to prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally. The Senior Scientist will be responsible for executing operational efficiency improvements and planning and implementing improvements across Bioprocess R&D work processes. The successful candidates must be able to endorse change to business infrastructure to ensure pipeline, legacy and technology success.


  • PhD with 0-3 years of experience or Master’s Degree with 3-6 years of experience with a concentration in a biological or engineering discipline (Biotechnology, Biochemistry, Chemical/Biochemical Engineering).
  • Experience in recombinant protein purification process development, technology transfer and/or bioprocess manufacturing required.
  • A good understanding of protein chemistry and protein analytics, including the recent scientific literature, is required.
  • The successful candidate will possess strong oral and written communication skills.
  • Strong analytical and computer skills are required.


  • Diverse work experience recovering gene therapy vectors.
  • Experience with high throughput technologies and Design of Experiments (DoE) is preferred.
  • Experience transferring biologics processes to pilot plants or manufacturing organizations, and knowledge of data acquisition and controls systems in these environments is desirable.
  • Experience taking a late-stage project through process validation and commercialization is desired.
  • It would be advantageous for the successful candidate to have a strong working knowledge of the drug development process for progression of a biological candidate.


Eligible for Employee Referral Bonus: Yes


  • This job is Pfizer Exempt US Grade: 009
  • US/PR colleagues who are issued an Incident Final Warning (IFW) disciplinary action are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.
  • US/PR colleagues who are issued an Incident Final Warning (IFW) disciplinary action are not eligible to post and compete for a position for a period of 12-months from the date an IFW is issued.
  • US/PR colleagues who are on an active Performance Improvement Plan (PIP) are not eligible to post and compete for a position for the duration of the Performance Improvement Plan (PIP).

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

See here for more information and to apply

Prior to application, please contact Kate Stuart for more information as this is a posting from an alumnus offering to assist in the process.

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