Department of Pharmacology

Faculty

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C. Michael Stein, M.B.Ch.B.

Dan May Chair in Medicine
Professor of Medicine
Professor of Pharmacology
BRET Profile (opens in a new window)
mike.stein@Vanderbilt.Edu
63420
http://www.mc.vanderbilt.edu/root/vumc.php?site=annetteoeser

Education

Dip Stats, Trinity College Dublin
M.D., Cape Town

Research Keywords



Publications

Birdwell, KA, Grady, B, Choi, L, Xu, H, Bian, A, Denny, JC, Jiang, M, Vranic, G, Basford, M, Cowan, JD, Richardson, DM, Robinson, MP, Ikizler, TA, Ritchie, MD, Stein, CM, Haas, DW. The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet Genomics, 22(1), 32-42, 2012

Kawai, VK, Stein, CM, Perrien, DS, Griffin, MR. Effects of anti-tumor necrosis factor I? agents on bone. Curr Opin Rheumatol, 2012

Bradham, WS, Bian, A, Oeser, A, Gebretsadik, T, Shintani, A, Solus, J, Estis, J, Lu, QA, Todd, J, Raggi, P, Stein, CM. High-sensitivity cardiac troponin-I is elevated in patients with rheumatoid arthritis, independent of cardiovascular risk factors and inflammation. PLoS One, 7(6), e38930, 2012

Ray, WA, Murray, KT, Hall, K, Arbogast, PG, Stein, CM. Azithromycin and the risk of cardiovascular death. N Engl J Med, 366(20), 1881-90, 2012

Kohli, U, Pandharipande, P, Muszkat, M, Sofowora, GG, Friedman, EA, Scheinin, M, Wood, AJ, Ely, EW, Tyndale, RF, Choi, L, Stein, CM, Kurnik, D. CYP2A6 genetic variation and dexmedetomidine disposition. Eur J Clin Pharmacol, 68(6), 937-42, 2012

Ghimire, LV, Kohli, U, Li, C, Sofowora, GG, Muszkat, M, Friedman, EA, Solus, JF, Wood, AJ, Stein, CM, Kurnik, D. Catecholamine pathway gene variation is associated with norepinephrine and epinephrine concentrations at rest and after exercise. Pharmacogenet Genomics, 22(4), 254-60, 2012

Lertnawapan, R, Bian, A, Rho, YH, Raggi, P, Oeser, A, Solus, JF, Gebretsadik, T, Shintani, A, Stein, CM. Cystatin C is associated with inflammation but not atherosclerosis in systemic lupus erythematosus. Lupus, 21(3), 279-87, 2012

Kawai, VK, Grijalva, CG, Arbogast, PG, Curtis, JR, Solomon, DH, Delzell, E, Chen, L, Ouellet-Hellstrom, R, Herrinton, L, Liu, L, Mitchel, EF, Stein, CM, Griffin, MR. Changes in cotherapies after initiation of disease-modifying antirheumatic drug therapy in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken), 63(10), 1415-24, 2011

Liu, M, Jiang, M, Kawai, VK, Stein, CM, Roden, DM, Denny, JC, Xu, H. Modeling drug exposure data in electronic medical records: an application to warfarin. AMIA Annu Symp Proc, 2011, 815-23, 2011

Cooper, WO, Habel, LA, Sox, CM, Chan, KA, Arbogast, PG, Cheetham, TC, Murray, KT, Quinn, VP, Stein, CM, Callahan, ST, Fireman, BH, Fish, FA, Kirshner, HS, O''Duffy, A, Connell, FA, Ray, WA. ADHD drugs and serious cardiovascular events in children and young adults. N Engl J Med, 365(20), 1896-904, 2011

Rho, YH, Solus, J, Raggi, P, Oeser, A, Gebretsadik, T, Shintani, A, Stein, CM. Macrophage activation and coronary atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Care Res (Hoboken), 63(4), 535-41, 2011

Muszkat, M, Kurnik, D, Sofowora, GG, Wood, AJ, Stein, CM. Independent regulation of I?1 and I?2 adrenergic receptor-mediated vasoconstriction in vivo. J Hypertens, 29(2), 251-6, 2011

Kawai, VK, Solus, JF, Oeser, A, Rho, YH, Raggi, P, Bian, A, Gebretsadik, T, Shintani, A, Stein, CM. Novel cardiovascular risk prediction models in patients with systemic lupus erythematosus. Lupus, 20(14), 1526-34, 2011

Choi, L, Caffo, BS, Kohli, U, Pandharipande, P, Kurnik, D, Ely, EW, Stein, CM. A Bayesian hierarchical nonlinear mixture model in the presence of artifactual outliers in a population pharmacokinetic study. J Pharmacokinet Pharmacodyn, 38(5), 613-36, 2011

Lertnawapan, R, Bian, A, Rho, YH, Kawai, VK, Raggi, P, Oeser, A, Solus, JF, Gebretsadik, T, Shintani, A, Stein, CM. Cystatin C, renal function, and atherosclerosis in rheumatoid arthritis. J Rheumatol, 38(11), 2297-300, 2011

Roden, DM, Wilke, RA, Kroemer, HK, Stein, CM. Pharmacogenomics: the genetics of variable drug responses. Circulation, 123(15), 1661-70, 2011

Kohli, U, Hahn, MK, English, BA, Sofowora, GG, Muszkat, M, Li, C, Blakely, RD, Stein, CM, Kurnik, D. Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans. Pharmacogenet Genomics, 21(4), 171-8, 2011

Kurnik, D, Muszkat, M, Li, C, Sofowora, GG, Friedman, EA, Scheinin, M, Wood, AJ, Stein, CM. Genetic variations in the I?(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine. Circ Cardiovasc Genet, 4(2), 179-87, 2011

Stein, CM, Ray, WA. The ethics of placebo in studies with fracture end points in osteoporosis. N Engl J Med, 363(14), 1367-70; discussion e21, 2010

Chung, CP, Oeser, A, Raggi, P, Sokka, T, Pincus, T, Solus, JF, Linton, MF, Fazio, S, Stein, CM. Lipoprotein subclasses determined by nuclear magnetic resonance spectroscopy and coronary atherosclerosis in patients with rheumatoid arthritis. J Rheumatol, 37(8), 1633-8, 2010

Ray, WA, Chung, CP, Murray, KT, Hall, K, Stein, CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med, 360(3), 225-35, 2009

Chung, CP, Oeser, A, Solus, JF, Avalos, I, Gebretsadik, T, Shintani, A, Raggi, P, Sokka, T, Pincus, T, Stein, CM. Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis, 196(2), 756-63, 2008

Chung, CP, Titova, D, Oeser, A, Randels, M, Avalos, I, Milne, GL, Morrow, JD, Stein, CM. Oxidative stress in fibromyalgia and its relationship to symptoms. Clin Rheumatol, 2008

Li, C, Schwarz, UI, Ritchie, MD, Roden, DM, Stein, CM, Kurnik, D. Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood, 2008

Kurnik, D, Li, C, Sofowora, GG, Friedman, EA, Muszkat, M, Xie, HG, Harris, PA, Williams, SM, Nair, UB, Wood, AJ, Stein, CM. Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade. Pharmacogenet Genomics, 18(10), 895-902, 2008

Solus, J, Chung, CP, Oeser, A, Avalos, I, Gebretsadik, T, Shintani, A, Raggi, P, Sokka, T, Pincus, T, Stein, CM. Amino-terminal fragment of the prohormone brain-type natriuretic peptide in rheumatoid arthritis. Arthritis Rheum, 58(9), 2662-9, 2008

Kurnik, D, Friedman, EA, Muszkat, M, Sofowora, GG, Xie, HG, Dupont, WD, Wood, AJ, Stein, CM. Genetic variants in the alpha2C-adrenoceptor and G-protein contribute to ethnic differences in cardiovascular stress responses. Pharmacogenet Genomics, 18(9), 743-50, 2008

Rho, YH, Chung, CP, Oeser, A, Solus, J, Raggi, P, Gebretsadik, T, Shintani, A, Stein, CM. Novel cardiovascular risk factors in premature coronary atherosclerosis associated with systemic lupus erythematosus. J Rheumatol, 35(9), 1789-94, 2008

Chung, CP, Oeser, A, Solus, JF, Gebretsadik, T, Shintani, A, Avalos, I, Sokka, T, Raggi, P, Pincus, T, Stein, CM. Inflammation-associated insulin resistance: differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms. Arthritis Rheum, 58(7), 2105-12, 2008

Grijalva, CG, Chung, CP, Stein, CM, Gideon, PS, Dyer, SM, Mitchel, EF, Griffin, MR. Computerized definitions showed high positive predictive values for identifying hospitalizations for congestive heart failure and selected infections in Medicaid enrollees with rheumatoid arthritis. Pharmacoepidemiol Drug Saf, 17(9), 890-5, 2008

Chung, CP, Solus, JF, Oeser, A, Avalos, I, Kurnik, D, Raggi, P, Stein, CM. N-terminal pro-brain natriuretic peptide in systemic lupus erythematosus: relationship with inflammation, augmentation index, and coronary calcification. J Rheumatol, 35(7), 1314-9, 2008

Grijalva, CG, Chung, CP, Stein, CM, Mitchel, EF, Griffin, MR. Changing patterns of medication use in patients with rheumatoid arthritis in a Medicaid population. Rheumatology (Oxford), 47(7), 1061-4, 2008

Chung, CP, Oeser, A, Raggi, P, Solus, JF, Avalos, I, Linton, MF, Fazio, S, Stein, CM. Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus. Clin Rheumatol, 27(10), 1227-33, 2008

Schwarz, UI, Ritchie, MD, Bradford, Y, Li, C, Dudek, SM, Frye-Anderson, A, Kim, RB, Roden, DM, Stein, CM. Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med, 358(10), 999-1008, 2008

Kurnik, D, Muszkat, M, Sofowora, GG, Friedman, EA, Dupont, WD, Scheinin, M, Wood, AJ, Stein, CM. Ethnic and genetic determinants of cardiovascular response to the selective alpha 2-adrenoceptor agonist dexmedetomidine. Hypertension, 51(2), 406-11, 2008

Kurnik, D, Muszkat, M, Friedman, EA, Sofowora, GG, Diedrich, A, Xie, HG, Harris, PA, Choi, L, Wood, AJ, Stein, CM. Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects. J Hypertens, 25(4), 763-71, 2007

Avalos, I, Chung, CP, Oeser, A, Milne, GL, Morrow, JD, Gebretsadik, T, Shintani, A, Yu, C, Stein, CM. Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms. Lupus, 16(3), 195-200, 2007

Chung, CP, Oeser, A, Solus, J, Avalos, I, Gebretsadik, T, Shintani, A, Linton, MF, Fazio, S, Stein, CM. Inflammatory mechanisms affecting the lipid profile in patients with systemic lupus erythematosus. J Rheumatol, 34(9), 1849-54, 2007

Ray, WA, Chung, CP, Stein, CM, Smalley, WE, Hall, K, Arbogast, PG, Griffin, MR. Risk of peptic ulcer hospitalizations in users of NSAIDs with gastroprotective cotherapy versus coxibs. Gastroenterology, 133(3), 790-8, 2007

Avalos, I, Chung, CP, Oeser, A, Milne, GL, Borntrager, H, Morrow, JD, Raggi, P, Solus, J, Stein, CM. Aspirin therapy and thromboxane biosynthesis in systemic lupus erythematosus. Lupus, 16(12), 981-6, 2007

Friedman, EA, Harris, PA, Wood, AJ, Stein, CM, Kurnik, D. The effects of tadalafil on cold-induced vasoconstriction in patients with Raynaud''s phenomenon. Clin Pharmacol Ther, 81(4), 503-9, 2007

Chung, CP, Avalos, I, Raggi, P, Stein, CM. Atherosclerosis and inflammation: insights from rheumatoid arthritis. Clin Rheumatol, 26(8), 1228-33, 2007

Avalos, I, Chung, CP, Oeser, A, Gebretsadik, T, Shintani, A, Kurnik, D, Raggi, P, Sokka, T, Pincus, T, Stein, CM. Increased augmentation index in rheumatoid arthritis and its relationship to coronary artery atherosclerosis. J Rheumatol, 34(12), 2388-94, 2007

Grijalva, CG, Chung, CP, Arbogast, PG, Stein, CM, Mitchel, EF, Griffin, MR. Assessment of adherence to and persistence on disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis. Med Care, 45(10 Supl 2), S66-76, 2007

Asanuma, Y, Chung, CP, Oeser, A, Shintani, A, Stanley, E, Raggi, P, Stein, CM. Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors. J Rheumatol, 33(3), 539-45, 2006

Chung, CP, Oeser, A, Avalos, I, Gebretsadik, T, Shintani, A, Raggi, P, Sokka, T, Pincus, T, Stein, CM. Utility of the Framingham risk score to predict the presence of coronary atherosclerosis in patients with rheumatoid arthritis. Arthritis Res Ther, 8(6), R186, 2006

Chung, CP, Oeser, A, Avalos, I, Raggi, P, Stein, CM. Cardiovascular risk scores and the presence of subclinical coronary artery atherosclerosis in women with systemic lupus erythematosus. Lupus, 15(9), 562-9, 2006

Schwarz, UI, Stein, CM. Genetic determinants of dose and clinical outcomes in patients receiving oral anticoagulants. Clin Pharmacol Ther, 80(1), 7-12, 2006

Ray, WA, Stein, CM. Reform of drug regulation--beyond an independent drug-safety board. N Engl J Med, 354(2), 194-201, 2006

Stanic, AK, Stein, CM, Morgan, AC, Fazio, S, Linton, MF, Wakeland, EK, Olsen, NJ, Major, AS. Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A, 103(18), 7018-23, 2006

Chung, CP, Avalos, I, Stein, CM. Oxidative stress, microvascular dysfunction, and scleroderma: an association with potential therapeutic implications, a commentary on &quot;Postocclusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosis&quot;. Free Radic Biol Med, 40(10), 1698-9, 2006

Kurnik, D, Muszkat, M, Li, C, Sofowora, GG, Solus, J, Xie, HG, Harris, PA, Jiang, L, McMunn, C, Ihrie, P, Dawson, EP, Williams, SM, Wood, AJ, Stein, CM. Variations in the alpha(2A)-adrenergic receptor gene and their functional effects. Clin Pharmacol Ther, 79(3), 173-85, 2006

Muszkat, M, Kurnik, D, Solus, J, Sofowora, GG, Xie, HG, Jiang, L, McMunn, C, Ihrie, P, Harris, JR, Dawson, EP, Williams, SM, Wood, AJ, Stein, CM. Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. Pharmacogenet Genomics, 15(6), 407-14, 2005

Turner, E, Dishy, V, Chung, CP, Harris, P, Pierces, R, Asanuma, Y, Oeser, A, Gebretsadik, T, Shintani, A, Raggi, P, Stein, CM. Endothelial function in systemic lupus erythematosus: relationship to disease activity, cardiovascular risk factors, corticosteroid therapy, and coronary calcification. Vasc Health Risk Manag, 1(4), 357-60, 2005

Sofowora, GG, Singh, I, He, HB, Wood, AJ, Stein, CM. Effect of acute transdermal estrogen administration on basal, mental stress and cold pressor-induced sympathetic responses in postmenopausal women. Clin Auton Res, 15(3), 193-9, 2005

Oeser, A, Chung, CP, Asanuma, Y, Avalos, I, Stein, CM. Obesity is an independent contributor to functional capacity and inflammation in systemic lupus erythematosus. Arthritis Rheum, 52(11), 3651-9, 2005

Chung, CP, Oeser, A, Raggi, P, Gebretsadik, T, Shintani, AK, Sokka, T, Pincus, T, Avalos, I, Stein, CM. Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors. Arthritis Rheum, 52(10), 3045-53, 2005

Muszkat, M, Sofowora, GG, Xie, HG, Wood, AJ, Stein, CM. Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. Pharmacogenet Genomics, 15(1), 23-8, 2005

Asanuma, Y, Xie, HG, Stein, CM. Pharmacogenetics and rheumatology: Molecular mechanisms contributing to variability in drug response. Arthritis Rheum, 52(5), 1349-59, 2005

Muszkat, M, Sofowora, GG, Wood, AJ, Stein, CM. Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites. Hypertension, 43(1), 31-5, 2004

Dishy, V, Harris, PA, Pierce, R, Prasad, HC, Sofowora, G, Bonar, HL, Wood, AJ, Stein, CM. Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers. Br J Clin Pharmacol, 57(2), 209-12, 2004

Olsen, NJ, Stein, CM. New drugs for rheumatoid arthritis. N Engl J Med, 350(21), 2167-79, 2004

Griffin, MR, Stein, CM, Graham, DJ, Daugherty, JR, Arbogast, PG, Ray, WA. High frequency of use of rofecoxib at greater than recommended doses: cause for concern. Pharmacoepidemiol Drug Saf, 13(6), 339-43, 2004

Griffin, MR, Stein, CM, Ray, WA. Postmarketing surveillance for drug safety: surely we can do better. Clin Pharmacol Ther, 75(6), 491-4, 2004

Sofowora, GG, Dishy, V, Landau, R, Xie, HG, Prasad, HC, Byrne, DW, Smiley, RM, Kim, RB, Wood, AJ, Stein, CM. Alpha 1A-adrenergic receptor polymorphism and vascular response. Clin Pharmacol Ther, 75(6), 539-45, 2004

Xie, HG, Wood, AJ, Kim, RB, Stein, CM, Wilkinson, GR. Genetic variability in CYP3A5 and its possible consequences. Pharmacogenomics, 5(3), 243-72, 2004

Dishy, V, Landau, R, Sofowora, GG, Xie, HG, Smiley, RM, Kim, RB, Byrne, DW, Wood, AJ, Stein, CM. Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo. Pharmacogenetics, 14(8), 517-22, 2004

Ray, WA, Murray, KT, Meredith, S, Narasimhulu, SS, Hall, K, Stein, CM. Oral erythromycin and the risk of sudden death from cardiac causes. N Engl J Med, 351(11), 1089-96, 2004

Stein, CM. Publishing work sponsored by the tobacco industry. Clin Pharmacol Ther, 76(6), 517-8, 2004

Sofowora, GG, Dishy, V, Muszkat, M, Xie, HG, Kim, RB, Harris, PA, Prasad, HC, Byrne, DW, Nair, UB, Wood, AJ, Stein, CM. A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. Clin Pharmacol Ther, 73(4), 366-71, 2003

Dishy, V, Sofowora, GG, Imamura, H, Nishimi, Y, Xie, HG, Wood, AJ, Stein, CM. Nitric oxide production decreases after salt loading but is not related to blood pressure changes or nitric oxide-mediated vascular responses. J Hypertens, 21(1), 153-7, 2003

Asanuma, Y, Oeser, A, Shintani, AK, Turner, E, Olsen, N, Fazio, S, Linton, MF, Raggi, P, Stein, CM. Premature coronary-artery atherosclerosis in systemic lupus erythematosus. N Engl J Med, 349(25), 2407-15, 2003

Dishy, V, Gupta, S, Landau, R, Xie, HG, Kim, RB, Smiley, RM, Byrne, DW, Wood, AJ, Stein, CM. G-protein beta(3) subunit 825 C/T polymorphism is associated with weight gain during pregnancy. Pharmacogenetics, 13(4), 241-2, 2003

Wandel, C, Kim, RB, Stein, CM. "Inactive" excipients such as Cremophor can affect in vivo drug disposition. Clin Pharmacol Ther, 73(5), 394-6, 2003

Stein, CM. Managing risk in healthy subjects participating in clinical research. Clin Pharmacol Ther, 74(6), 511-2, 2003

Ray, WA, Stein, CM, Daugherty, JR, Hall, K, Arbogast, PG, Griffin, MR. COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. Lancet, 360(9339), 1071-3, 2002

Smalley, W, Stein, CM, Arbogast, PG, Eisen, G, Ray, WA, Griffin, M. Underutilization of gastroprotective measures in patients receiving nonsteroidal antiinflammatory drugs. Arthritis Rheum, 46(8), 2195-200, 2002

Ray, WA, Stein, CM, Hall, K, Daugherty, JR, Griffin, MR. Non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease: an observational cohort study. Lancet, 359(9301), 118-23, 2002